Liquid-liquid phase separation in DNA double-strand breaks repair
Abstract DNA double-strand breaks (DSBs) are the fatal type of DNA damage mostly induced by exposure genome to ionizing radiation or genotoxic chemicals. DSBs are mainly repaired by homologous recombination (HR) and nonhomologous end joining (NHEJ). To repair DSBs, a large amount of DNA repair facto...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2023-11-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-023-06267-0 |
| _version_ | 1797556081105305600 |
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| author | Yun-Long Wang Wan-Wen Zhao Jie Shi Xiang-Bo Wan Jian Zheng Xin-Juan Fan |
| author_facet | Yun-Long Wang Wan-Wen Zhao Jie Shi Xiang-Bo Wan Jian Zheng Xin-Juan Fan |
| author_sort | Yun-Long Wang |
| collection | DOAJ |
| description | Abstract DNA double-strand breaks (DSBs) are the fatal type of DNA damage mostly induced by exposure genome to ionizing radiation or genotoxic chemicals. DSBs are mainly repaired by homologous recombination (HR) and nonhomologous end joining (NHEJ). To repair DSBs, a large amount of DNA repair factors was observed to be concentrated at the end of DSBs in a specific spatiotemporal manner to form a repair center. Recently, this repair center was characterized as a condensate derived from liquid-liquid phase separation (LLPS) of key DSBs repair factors. LLPS has been found to be the mechanism of membraneless organelles formation and plays key roles in a variety of biological processes. In this review, the recent advances and mechanisms of LLPS in the formation of DSBs repair-related condensates are summarized. |
| first_indexed | 2024-03-10T16:56:40Z |
| format | Article |
| id | doaj.art-37087f77236f482fb697648277d8055a |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-03-10T16:56:40Z |
| publishDate | 2023-11-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-37087f77236f482fb697648277d8055a2023-11-20T11:05:51ZengNature Publishing GroupCell Death and Disease2041-48892023-11-01141111010.1038/s41419-023-06267-0Liquid-liquid phase separation in DNA double-strand breaks repairYun-Long Wang0Wan-Wen Zhao1Jie Shi2Xiang-Bo Wan3Jian Zheng4Xin-Juan Fan5Henan Provincial Key Laboratory of Radiation Medicine, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen UniversityDepartment of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen UniversityHenan Provincial Key Laboratory of Radiation Medicine, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen UniversityHenan Provincial Key Laboratory of Radiation Medicine, The First Affiliated Hospital of Zhengzhou UniversityAbstract DNA double-strand breaks (DSBs) are the fatal type of DNA damage mostly induced by exposure genome to ionizing radiation or genotoxic chemicals. DSBs are mainly repaired by homologous recombination (HR) and nonhomologous end joining (NHEJ). To repair DSBs, a large amount of DNA repair factors was observed to be concentrated at the end of DSBs in a specific spatiotemporal manner to form a repair center. Recently, this repair center was characterized as a condensate derived from liquid-liquid phase separation (LLPS) of key DSBs repair factors. LLPS has been found to be the mechanism of membraneless organelles formation and plays key roles in a variety of biological processes. In this review, the recent advances and mechanisms of LLPS in the formation of DSBs repair-related condensates are summarized.https://doi.org/10.1038/s41419-023-06267-0 |
| spellingShingle | Yun-Long Wang Wan-Wen Zhao Jie Shi Xiang-Bo Wan Jian Zheng Xin-Juan Fan Liquid-liquid phase separation in DNA double-strand breaks repair Cell Death and Disease |
| title | Liquid-liquid phase separation in DNA double-strand breaks repair |
| title_full | Liquid-liquid phase separation in DNA double-strand breaks repair |
| title_fullStr | Liquid-liquid phase separation in DNA double-strand breaks repair |
| title_full_unstemmed | Liquid-liquid phase separation in DNA double-strand breaks repair |
| title_short | Liquid-liquid phase separation in DNA double-strand breaks repair |
| title_sort | liquid liquid phase separation in dna double strand breaks repair |
| url | https://doi.org/10.1038/s41419-023-06267-0 |
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