Application of lactobionic acid and nonionic surfactants as solubilizing agents for parenteral formulation of clarithromycin

Application of lactobionic acid and nonionic surfactants as solubilizing agents for parenteral formulation of clarithromycin

Purpose: The purpose of this paper is to enhance the solubility of clarithromycin (CLR) using nonionic surfactants and some type of acids for preparation of the new formulations. Methods: Myrj 52 and chremophor (2.5 and 5% w/v) were used in two concentrations. To investigate solubility, the formulat...

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Bibliographic Details
Main Authors: Mohammad-Hosein Zarrintan, Hadi Valizadeh, Saeed Ghanbarzadeh, Parvin Zakeri-Milani, Niaz Mousavian-Fathi
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2012-06-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
Clarithromycin
Lactobionic acid
Nonionic surfactants
Solubility
Parenteral
Online Access:http://apb.tbzmed.ac.ir/Portals/0/Archive/Vol2No1/6.Zakeri.pdf

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