Re: Epigenetics of Cellular Reprogramming
EDITORIAL COMMENT Cells have some specific molecular and physiological properties that act their functional process. However, many cells have an ability of efficient transition from one type to another. This ability is named plasticity. This process occurs due to epigenetic reprogramming that inv...
| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2016-12-01
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| Series: | Journal of Urological Surgery |
| Online Access: | http://jurolsurgery.org/article_10919/Re-Epigenetics-Of-Cellular-Reprogramming |
| _version_ | 1797916356910252032 |
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| author | Fehmi Narter |
| author_facet | Fehmi Narter |
| author_sort | Fehmi Narter |
| collection | DOAJ |
| description | EDITORIAL COMMENT
Cells have some specific molecular and physiological properties that act their functional process. However, many cells have an ability of efficient transition from one type to another. This ability is named plasticity. This process occurs due to epigenetic reprogramming that involves changes in transcription and chromatin structure. Some changes during reprogramming that have been identified in recent years as genomic demethylation (both histone and DNA), histone acetylation and loss of heterochromatin during the development of many diseases such as infertility and cancer progression. In this review, the authors focused on the latest work addressing the mechanisms surrounding the epigenetic regulation of various types of reprogramming, including somatic cell nuclear transfer, cell fusion and transcription factor- and microRNA-induced pluripotency. There are many responsible factors such as genes, cytokines, proteins, co-factors (i.e. vitamin C) in this local area network. The exact mechanisms by which these changes are achieved and the detailed interplay between the players responsible, however, remain relatively unclear. In the treatment of diseases, such as infertility, urooncology, reconstructive urology, etc., epigenetic changes and cellular reprogramming will be crucial in the near future. Central to achieving that goal is a more thorough understanding of the epigenetic state of fully reprogrammed cells. By the progress of researches on this topic, new treatment modalities will be identified for these diseases. |
| first_indexed | 2024-04-10T12:55:49Z |
| format | Article |
| id | doaj.art-3708e1b4cb3a4daa8816974ccb166527 |
| institution | Directory Open Access Journal |
| issn | 2148-9580 |
| language | English |
| last_indexed | 2024-04-10T12:55:49Z |
| publishDate | 2016-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Urological Surgery |
| spelling | doaj.art-3708e1b4cb3a4daa8816974ccb1665272023-02-15T16:13:27ZengGalenos YayineviJournal of Urological Surgery2148-95802016-12-013415215210.4274/jus.2016.03.037Re: Epigenetics of Cellular ReprogrammingFehmi NarterEDITORIAL COMMENT Cells have some specific molecular and physiological properties that act their functional process. However, many cells have an ability of efficient transition from one type to another. This ability is named plasticity. This process occurs due to epigenetic reprogramming that involves changes in transcription and chromatin structure. Some changes during reprogramming that have been identified in recent years as genomic demethylation (both histone and DNA), histone acetylation and loss of heterochromatin during the development of many diseases such as infertility and cancer progression. In this review, the authors focused on the latest work addressing the mechanisms surrounding the epigenetic regulation of various types of reprogramming, including somatic cell nuclear transfer, cell fusion and transcription factor- and microRNA-induced pluripotency. There are many responsible factors such as genes, cytokines, proteins, co-factors (i.e. vitamin C) in this local area network. The exact mechanisms by which these changes are achieved and the detailed interplay between the players responsible, however, remain relatively unclear. In the treatment of diseases, such as infertility, urooncology, reconstructive urology, etc., epigenetic changes and cellular reprogramming will be crucial in the near future. Central to achieving that goal is a more thorough understanding of the epigenetic state of fully reprogrammed cells. By the progress of researches on this topic, new treatment modalities will be identified for these diseases.http://jurolsurgery.org/article_10919/Re-Epigenetics-Of-Cellular-Reprogramming |
| spellingShingle | Fehmi Narter Re: Epigenetics of Cellular Reprogramming Journal of Urological Surgery |
| title | Re: Epigenetics of Cellular Reprogramming |
| title_full | Re: Epigenetics of Cellular Reprogramming |
| title_fullStr | Re: Epigenetics of Cellular Reprogramming |
| title_full_unstemmed | Re: Epigenetics of Cellular Reprogramming |
| title_short | Re: Epigenetics of Cellular Reprogramming |
| title_sort | re epigenetics of cellular reprogramming |
| url | http://jurolsurgery.org/article_10919/Re-Epigenetics-Of-Cellular-Reprogramming |
| work_keys_str_mv | AT fehminarter reepigeneticsofcellularreprogramming |