A CASE OF COMBINED CENTRAL AND PERIPHERAL DEMYELINATION IN A PATIENT WITH PEDIATRIC MULTIPLE SCLEROSIS AFTER SARS-COV-2 VACCINATION
We present a case of combined central and peripheral demyelination in a patient with pediatric multiple sclerosis after the first dose of ChAdOx1-S (Chimpanzee Adenovirus Oxford 1) vaccination. The patient presented with ascending flaccid quadriparesis with respiratory failure that required mechanic...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Brawijaya
2022-12-01
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| Series: | Malang Neurology Journal |
| Subjects: | |
| Online Access: | https://mnj.ub.ac.id/index.php/mnj/article/view/666 |
| _version_ | 1797740436667760640 |
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| author | Angeloglou Stella Gkantzios Aimilios Kourtesis Ioannis Samaras Nikolasos Barmpari Athanasia Filippi Aikaterini Taulant Jupe Kosta Natalia Maltezou Maria |
| author_facet | Angeloglou Stella Gkantzios Aimilios Kourtesis Ioannis Samaras Nikolasos Barmpari Athanasia Filippi Aikaterini Taulant Jupe Kosta Natalia Maltezou Maria |
| author_sort | Angeloglou Stella |
| collection | DOAJ |
| description | We present a case of combined central and peripheral demyelination in a patient with pediatric multiple sclerosis after the first dose of ChAdOx1-S (Chimpanzee Adenovirus Oxford 1) vaccination. The patient presented with ascending flaccid quadriparesis with respiratory failure that required mechanical ventilation. The lumbar puncture revealed albuminocytological dissociation, was negative for presence of JCV (John Cunningham Virus) in the CSF (Cerebrospinal Fluid) and ruled out other infections. A few days later he developed anisocoria and multiple new enlarging acute demyelinating lesions in the brain MRI (Magnetic Resonance Imaging). He was treated with intravenous immunoglobulin, corticosteroids and plasma exchange with gradual improvement. All other diseases were excluded via MR Spectroscopy, MR Angiography and serum and CSF laboratory investigations. Seven months later, the patient is under intense physiotherapy and is improving every day. |
| first_indexed | 2024-03-12T14:12:25Z |
| format | Article |
| id | doaj.art-3709d5148a73439fac4020379947c7de |
| institution | Directory Open Access Journal |
| issn | 2407-6724 2442-5001 |
| language | English |
| last_indexed | 2024-03-12T14:12:25Z |
| publishDate | 2022-12-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Malang Neurology Journal |
| spelling | doaj.art-3709d5148a73439fac4020379947c7de2023-08-21T06:33:08ZengUniversity of BrawijayaMalang Neurology Journal2407-67242442-50012022-12-0191586110.21776/ub.mnj.2023.009.01.12458A CASE OF COMBINED CENTRAL AND PERIPHERAL DEMYELINATION IN A PATIENT WITH PEDIATRIC MULTIPLE SCLEROSIS AFTER SARS-COV-2 VACCINATIONAngeloglou Stella0Gkantzios Aimilios1Kourtesis Ioannis2Samaras Nikolasos3Barmpari Athanasia4Filippi Aikaterini5Taulant Jupe6Kosta Natalia7Maltezou Maria8Neurology Clinic, General Oncological Hospital of Kifisia Oi Agioi Anargyroi, GreeceNeurology Clinic, General Oncological Hospital of Kifisia Oi Agioi Anargyroi, Greece.Neurology Clinic, General Oncological Hospital of Kifisia Oi Agioi Anargyroi, Greece.Neurology Clinic, General Oncological Hospital of Kifisia Oi Agioi Anargyroi, Greece.Neurology Clinic, General Oncological Hospital of Kifisia Oi Agioi Anargyroi, GreeceNeurology Clinic, General Oncological Hospital of Kifisia Oi Agioi Anargyroi, GreeceNeurology Clinic, General Oncological Hospital of Kifisia Oi Agioi Anargyroi, GreeceIntensive Care Unit, General Oncological Hospital of Kifisia Oi Agioi Anargyroi, GreeceNeurology Clinic, General Oncological Hospital of Kifisia Oi Agioi Anargyroi, GreeceWe present a case of combined central and peripheral demyelination in a patient with pediatric multiple sclerosis after the first dose of ChAdOx1-S (Chimpanzee Adenovirus Oxford 1) vaccination. The patient presented with ascending flaccid quadriparesis with respiratory failure that required mechanical ventilation. The lumbar puncture revealed albuminocytological dissociation, was negative for presence of JCV (John Cunningham Virus) in the CSF (Cerebrospinal Fluid) and ruled out other infections. A few days later he developed anisocoria and multiple new enlarging acute demyelinating lesions in the brain MRI (Magnetic Resonance Imaging). He was treated with intravenous immunoglobulin, corticosteroids and plasma exchange with gradual improvement. All other diseases were excluded via MR Spectroscopy, MR Angiography and serum and CSF laboratory investigations. Seven months later, the patient is under intense physiotherapy and is improving every day.https://mnj.ub.ac.id/index.php/mnj/article/view/666combined central and peripheral demyelinationmultiple sclerosissars-cov-2 vaccinationadem |
| spellingShingle | Angeloglou Stella Gkantzios Aimilios Kourtesis Ioannis Samaras Nikolasos Barmpari Athanasia Filippi Aikaterini Taulant Jupe Kosta Natalia Maltezou Maria A CASE OF COMBINED CENTRAL AND PERIPHERAL DEMYELINATION IN A PATIENT WITH PEDIATRIC MULTIPLE SCLEROSIS AFTER SARS-COV-2 VACCINATION Malang Neurology Journal combined central and peripheral demyelination multiple sclerosis sars-cov-2 vaccination adem |
| title | A CASE OF COMBINED CENTRAL AND PERIPHERAL DEMYELINATION IN A PATIENT WITH PEDIATRIC MULTIPLE SCLEROSIS AFTER SARS-COV-2 VACCINATION |
| title_full | A CASE OF COMBINED CENTRAL AND PERIPHERAL DEMYELINATION IN A PATIENT WITH PEDIATRIC MULTIPLE SCLEROSIS AFTER SARS-COV-2 VACCINATION |
| title_fullStr | A CASE OF COMBINED CENTRAL AND PERIPHERAL DEMYELINATION IN A PATIENT WITH PEDIATRIC MULTIPLE SCLEROSIS AFTER SARS-COV-2 VACCINATION |
| title_full_unstemmed | A CASE OF COMBINED CENTRAL AND PERIPHERAL DEMYELINATION IN A PATIENT WITH PEDIATRIC MULTIPLE SCLEROSIS AFTER SARS-COV-2 VACCINATION |
| title_short | A CASE OF COMBINED CENTRAL AND PERIPHERAL DEMYELINATION IN A PATIENT WITH PEDIATRIC MULTIPLE SCLEROSIS AFTER SARS-COV-2 VACCINATION |
| title_sort | case of combined central and peripheral demyelination in a patient with pediatric multiple sclerosis after sars cov 2 vaccination |
| topic | combined central and peripheral demyelination multiple sclerosis sars-cov-2 vaccination adem |
| url | https://mnj.ub.ac.id/index.php/mnj/article/view/666 |
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