New Dammarane-Type Saponins from <i>Gynostemma pentaphyllum</i>

New Dammarane-Type Saponins from <i>Gynostemma pentaphyllum</i>

Six new dammarane-type saponins, gypenosides CP1-6 (<b>1</b>–<b>6</b>), along with 19 known compounds <b>7</b>–<b>25</b>, were isolated and characterized from the aerial parts of <i>Gynostemma pentaphyllum</i>. Among the...

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Bibliographic Details
Main Authors:	Po-Yen Chen, Chih-Chao Chang, Hui-Chi Huang, Li-Jie Zhang, Chia-Ching Liaw, Yu-Chi Lin, Nham-Linh Nguyen, Thanh-Hoa Vo, Yung-Yi Cheng, Susan L. Morris-Natschke, Kuo-Hsiung Lee, Yao-Haur Kuo
Format:	Article
Language:	English
Published:	MDPI AG 2019-04-01
Series:	Molecules
Subjects:	<i>Gynostemma pentaphyllum</i> Jiaogulan dammarane-type saponins gypenosides antiproliferative activity
Online Access:	https://www.mdpi.com/1420-3049/24/7/1375

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Summary:	Six new dammarane-type saponins, gypenosides CP1-6 (<b>1</b>–<b>6</b>), along with 19 known compounds <b>7</b>–<b>25</b>, were isolated and characterized from the aerial parts of <i>Gynostemma pentaphyllum</i>. Among these compounds, eight dammarane-type saponins, <b>2</b>, <b>5</b>, <b>6</b>, <b>7</b>, <b>11</b>, <b>12</b>, <b>13</b>, and <b>15,</b> exhibited the greatest antiproliferative effects against two human tumor cell lines (A549 and HepG2).
ISSN:	1420-3049