New Dammarane-Type Saponins from <i>Gynostemma pentaphyllum</i>
Six new dammarane-type saponins, gypenosides CP1-6 (<b>1</b>–<b>6</b>), along with 19 known compounds <b>7</b>–<b>25</b>, were isolated and characterized from the aerial parts of <i>Gynostemma pentaphyllum</i>. Among the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/7/1375 |
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| author | Po-Yen Chen Chih-Chao Chang Hui-Chi Huang Li-Jie Zhang Chia-Ching Liaw Yu-Chi Lin Nham-Linh Nguyen Thanh-Hoa Vo Yung-Yi Cheng Susan L. Morris-Natschke Kuo-Hsiung Lee Yao-Haur Kuo |
| author_facet | Po-Yen Chen Chih-Chao Chang Hui-Chi Huang Li-Jie Zhang Chia-Ching Liaw Yu-Chi Lin Nham-Linh Nguyen Thanh-Hoa Vo Yung-Yi Cheng Susan L. Morris-Natschke Kuo-Hsiung Lee Yao-Haur Kuo |
| author_sort | Po-Yen Chen |
| collection | DOAJ |
| description | Six new dammarane-type saponins, gypenosides CP1-6 (<b>1</b>–<b>6</b>), along with 19 known compounds <b>7</b>–<b>25</b>, were isolated and characterized from the aerial parts of <i>Gynostemma pentaphyllum</i>. Among these compounds, eight dammarane-type saponins, <b>2</b>, <b>5</b>, <b>6</b>, <b>7</b>, <b>11</b>, <b>12</b>, <b>13</b>, and <b>15,</b> exhibited the greatest antiproliferative effects against two human tumor cell lines (A549 and HepG2). |
| first_indexed | 2024-04-14T01:15:41Z |
| format | Article |
| id | doaj.art-370ab45eb24a47c1b2c67d2b6e623841 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-14T01:15:41Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-370ab45eb24a47c1b2c67d2b6e6238412022-12-22T02:20:51ZengMDPI AGMolecules1420-30492019-04-01247137510.3390/molecules24071375molecules24071375New Dammarane-Type Saponins from <i>Gynostemma pentaphyllum</i>Po-Yen Chen0Chih-Chao Chang1Hui-Chi Huang2Li-Jie Zhang3Chia-Ching Liaw4Yu-Chi Lin5Nham-Linh Nguyen6Thanh-Hoa Vo7Yung-Yi Cheng8Susan L. Morris-Natschke9Kuo-Hsiung Lee10Yao-Haur Kuo11Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, TaiwanDivision of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, TaiwanDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, TaiwanDivision of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, TaiwanDepartment of Research and Development, Starsci Biotech Co. Ltd., Taipei 112, TaiwanDivision of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, TaiwanDivision of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, TaiwanDivision of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, TaiwanNatural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USANatural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USANatural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USADivision of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, TaiwanSix new dammarane-type saponins, gypenosides CP1-6 (<b>1</b>–<b>6</b>), along with 19 known compounds <b>7</b>–<b>25</b>, were isolated and characterized from the aerial parts of <i>Gynostemma pentaphyllum</i>. Among these compounds, eight dammarane-type saponins, <b>2</b>, <b>5</b>, <b>6</b>, <b>7</b>, <b>11</b>, <b>12</b>, <b>13</b>, and <b>15,</b> exhibited the greatest antiproliferative effects against two human tumor cell lines (A549 and HepG2).https://www.mdpi.com/1420-3049/24/7/1375<i>Gynostemma pentaphyllum</i>Jiaogulandammarane-type saponinsgypenosides antiproliferative activity |
| spellingShingle | Po-Yen Chen Chih-Chao Chang Hui-Chi Huang Li-Jie Zhang Chia-Ching Liaw Yu-Chi Lin Nham-Linh Nguyen Thanh-Hoa Vo Yung-Yi Cheng Susan L. Morris-Natschke Kuo-Hsiung Lee Yao-Haur Kuo New Dammarane-Type Saponins from <i>Gynostemma pentaphyllum</i> Molecules <i>Gynostemma pentaphyllum</i> Jiaogulan dammarane-type saponins gypenosides antiproliferative activity |
| title | New Dammarane-Type Saponins from <i>Gynostemma pentaphyllum</i> |
| title_full | New Dammarane-Type Saponins from <i>Gynostemma pentaphyllum</i> |
| title_fullStr | New Dammarane-Type Saponins from <i>Gynostemma pentaphyllum</i> |
| title_full_unstemmed | New Dammarane-Type Saponins from <i>Gynostemma pentaphyllum</i> |
| title_short | New Dammarane-Type Saponins from <i>Gynostemma pentaphyllum</i> |
| title_sort | new dammarane type saponins from i gynostemma pentaphyllum i |
| topic | <i>Gynostemma pentaphyllum</i> Jiaogulan dammarane-type saponins gypenosides antiproliferative activity |
| url | https://www.mdpi.com/1420-3049/24/7/1375 |
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