Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity

Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity

ABSTRACT HIV-1 evades antibody-dependent cellular cytotoxicity (ADCC) responses not only by controlling Env conformation and quantity at the cell surface but also by altering NK cell activation via the downmodulation of several ligands of activating and co-activating NK cell receptors. The signaling...

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Bibliographic Details
Main Authors: Lorie Marchitto, Mehdi Benlarbi, Jérémie Prévost, Annemarie Laumaea, Jade Descôteaux-Dinelle, Halima Medjahed, Catherine Bourassa, Gabrielle Gendron-Lepage, Frank Kirchhoff, Daniel Sauter, Beatrice H. Hahn, Andrés Finzi, Jonathan Richard
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
HIV-1
NK cell
Vpu
Nef
CD48
NTB-A
Online Access:https://journals.asm.org/doi/10.1128/mbio.00789-23

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