The Effect of Short-Term Transcutaneous Electrical Stimulation of Auricular Vagus Nerve on Parameters of Heart Rate Variability
Many previous studies have demonstrated that transcutaneous vagus nerve stimulation (VNS) has the potential to exhibit therapeutic effects similar to its invasive counterpart. An objective assessment of VNS requires a reliable biomarker of successful vagal activation. Although many potential biomark...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Data |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5729/8/5/87 |
| _version_ | 1797600464437510144 |
|---|---|
| author | Vladimir Shvartz Eldar Sizhazhev Maria Sokolskaya Svetlana Koroleva Soslan Enginoev Sofia Kruchinova Elena Shvartz Elena Golukhova |
| author_facet | Vladimir Shvartz Eldar Sizhazhev Maria Sokolskaya Svetlana Koroleva Soslan Enginoev Sofia Kruchinova Elena Shvartz Elena Golukhova |
| author_sort | Vladimir Shvartz |
| collection | DOAJ |
| description | Many previous studies have demonstrated that transcutaneous vagus nerve stimulation (VNS) has the potential to exhibit therapeutic effects similar to its invasive counterpart. An objective assessment of VNS requires a reliable biomarker of successful vagal activation. Although many potential biomarkers have been proposed, most studies have focused on heart rate variability (HRV). Despite the physiological rationale for HRV as a biomarker for assessing vagal stimulation, data on its effects on HRV are equivocal. To further advance this field, future studies investigating VNS should contain adequate methodological specifics that make it possible to compare the results between studies, to replicate studies, and to enhance the safety of study participants. This article describes the design and methodology of a randomized study evaluating the effect of short-term noninvasive stimulation of the auricular branch of the vagus nerve on parameters of HRV. Primary records of rhythmograms of all the subjects, as well as a dataset with clinical, instrumental, and laboratory data of all the current study subjects are in the public domain for possible secondary analysis to all interested researchers. The physiological interpretation of the obtained data is not considered in the article. |
| first_indexed | 2024-03-11T03:49:30Z |
| format | Article |
| id | doaj.art-370b34c966864851922f99e410925994 |
| institution | Directory Open Access Journal |
| issn | 2306-5729 |
| language | English |
| last_indexed | 2024-03-11T03:49:30Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Data |
| spelling | doaj.art-370b34c966864851922f99e4109259942023-11-18T01:02:29ZengMDPI AGData2306-57292023-05-01858710.3390/data8050087The Effect of Short-Term Transcutaneous Electrical Stimulation of Auricular Vagus Nerve on Parameters of Heart Rate VariabilityVladimir Shvartz0Eldar Sizhazhev1Maria Sokolskaya2Svetlana Koroleva3Soslan Enginoev4Sofia Kruchinova5Elena Shvartz6Elena Golukhova7Bakulev National Medical Research Center for Cardiovascular Surgery, Moscow 121552, RussiaBakulev National Medical Research Center for Cardiovascular Surgery, Moscow 121552, RussiaBakulev National Medical Research Center for Cardiovascular Surgery, Moscow 121552, RussiaBakulev National Medical Research Center for Cardiovascular Surgery, Moscow 121552, RussiaFederal Center for Cardiovascular Surgery (Astrakhan), Astrakhan 414011, RussiaScientific Research Institute of Regional Clinical Hospital #1 NA Professor Ochapovsky, Krasnodar 350086, RussiaNational Medical Research Center for Therapy and Preventive Medicine, Moscow 101990, RussiaBakulev National Medical Research Center for Cardiovascular Surgery, Moscow 121552, RussiaMany previous studies have demonstrated that transcutaneous vagus nerve stimulation (VNS) has the potential to exhibit therapeutic effects similar to its invasive counterpart. An objective assessment of VNS requires a reliable biomarker of successful vagal activation. Although many potential biomarkers have been proposed, most studies have focused on heart rate variability (HRV). Despite the physiological rationale for HRV as a biomarker for assessing vagal stimulation, data on its effects on HRV are equivocal. To further advance this field, future studies investigating VNS should contain adequate methodological specifics that make it possible to compare the results between studies, to replicate studies, and to enhance the safety of study participants. This article describes the design and methodology of a randomized study evaluating the effect of short-term noninvasive stimulation of the auricular branch of the vagus nerve on parameters of HRV. Primary records of rhythmograms of all the subjects, as well as a dataset with clinical, instrumental, and laboratory data of all the current study subjects are in the public domain for possible secondary analysis to all interested researchers. The physiological interpretation of the obtained data is not considered in the article.https://www.mdpi.com/2306-5729/8/5/87auricular stimulationauricular vagus nerve stimulationtranscutaneous auricular vagus nerve stimulationheart rate variabilityparasympathetic nervous system |
| spellingShingle | Vladimir Shvartz Eldar Sizhazhev Maria Sokolskaya Svetlana Koroleva Soslan Enginoev Sofia Kruchinova Elena Shvartz Elena Golukhova The Effect of Short-Term Transcutaneous Electrical Stimulation of Auricular Vagus Nerve on Parameters of Heart Rate Variability Data auricular stimulation auricular vagus nerve stimulation transcutaneous auricular vagus nerve stimulation heart rate variability parasympathetic nervous system |
| title | The Effect of Short-Term Transcutaneous Electrical Stimulation of Auricular Vagus Nerve on Parameters of Heart Rate Variability |
| title_full | The Effect of Short-Term Transcutaneous Electrical Stimulation of Auricular Vagus Nerve on Parameters of Heart Rate Variability |
| title_fullStr | The Effect of Short-Term Transcutaneous Electrical Stimulation of Auricular Vagus Nerve on Parameters of Heart Rate Variability |
| title_full_unstemmed | The Effect of Short-Term Transcutaneous Electrical Stimulation of Auricular Vagus Nerve on Parameters of Heart Rate Variability |
| title_short | The Effect of Short-Term Transcutaneous Electrical Stimulation of Auricular Vagus Nerve on Parameters of Heart Rate Variability |
| title_sort | effect of short term transcutaneous electrical stimulation of auricular vagus nerve on parameters of heart rate variability |
| topic | auricular stimulation auricular vagus nerve stimulation transcutaneous auricular vagus nerve stimulation heart rate variability parasympathetic nervous system |
| url | https://www.mdpi.com/2306-5729/8/5/87 |
| work_keys_str_mv | AT vladimirshvartz theeffectofshorttermtranscutaneouselectricalstimulationofauricularvagusnerveonparametersofheartratevariability AT eldarsizhazhev theeffectofshorttermtranscutaneouselectricalstimulationofauricularvagusnerveonparametersofheartratevariability AT mariasokolskaya theeffectofshorttermtranscutaneouselectricalstimulationofauricularvagusnerveonparametersofheartratevariability AT svetlanakoroleva theeffectofshorttermtranscutaneouselectricalstimulationofauricularvagusnerveonparametersofheartratevariability AT soslanenginoev theeffectofshorttermtranscutaneouselectricalstimulationofauricularvagusnerveonparametersofheartratevariability AT sofiakruchinova theeffectofshorttermtranscutaneouselectricalstimulationofauricularvagusnerveonparametersofheartratevariability AT elenashvartz theeffectofshorttermtranscutaneouselectricalstimulationofauricularvagusnerveonparametersofheartratevariability AT elenagolukhova theeffectofshorttermtranscutaneouselectricalstimulationofauricularvagusnerveonparametersofheartratevariability AT vladimirshvartz effectofshorttermtranscutaneouselectricalstimulationofauricularvagusnerveonparametersofheartratevariability AT eldarsizhazhev effectofshorttermtranscutaneouselectricalstimulationofauricularvagusnerveonparametersofheartratevariability AT mariasokolskaya effectofshorttermtranscutaneouselectricalstimulationofauricularvagusnerveonparametersofheartratevariability AT svetlanakoroleva effectofshorttermtranscutaneouselectricalstimulationofauricularvagusnerveonparametersofheartratevariability AT soslanenginoev effectofshorttermtranscutaneouselectricalstimulationofauricularvagusnerveonparametersofheartratevariability AT sofiakruchinova effectofshorttermtranscutaneouselectricalstimulationofauricularvagusnerveonparametersofheartratevariability AT elenashvartz effectofshorttermtranscutaneouselectricalstimulationofauricularvagusnerveonparametersofheartratevariability AT elenagolukhova effectofshorttermtranscutaneouselectricalstimulationofauricularvagusnerveonparametersofheartratevariability |