Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice
Enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available. In this work, we found that the number of B cells was reduced in enterovirus 71-infected mice. Deferoxamine, a marine micro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-07-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/12/7/4086 |
| _version_ | 1798034909011378176 |
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| author | Yajun Yang Jing Ma Jinghui Xiu Lin Bai Feifei Guan Li Zhang Jiangning Liu Lianfeng Zhang |
| author_facet | Yajun Yang Jing Ma Jinghui Xiu Lin Bai Feifei Guan Li Zhang Jiangning Liu Lianfeng Zhang |
| author_sort | Yajun Yang |
| collection | DOAJ |
| description | Enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available. In this work, we found that the number of B cells was reduced in enterovirus 71-infected mice. Deferoxamine, a marine microbial natural product, compensated for the decreased levels of B cells caused by enterovirus 71 infection. The neutralizing antibody titer was also improved after deferoxamine treatment. Furthermore, deferoxamine relieved symptoms and reduced mortality and muscle damage caused by enterovirus 71 infection. This work suggested that deferoxamine has the potential for further development as a B cell-immunomodulator against enterovirus 71. |
| first_indexed | 2024-04-11T20:50:48Z |
| format | Article |
| id | doaj.art-370b8e6cba1a47b69dbd395c7c2c9d8f |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T20:50:48Z |
| publishDate | 2014-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-370b8e6cba1a47b69dbd395c7c2c9d8f2022-12-22T04:03:51ZengMDPI AGMarine Drugs1660-33972014-07-011274086409510.3390/md12074086md12074086Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected MiceYajun Yang0Jing Ma1Jinghui Xiu2Lin Bai3Feifei Guan4Li Zhang5Jiangning Liu6Lianfeng Zhang7Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, ChinaKey Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, ChinaKey Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, ChinaKey Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, ChinaKey Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, ChinaKey Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, ChinaKey Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, ChinaKey Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, ChinaEnterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available. In this work, we found that the number of B cells was reduced in enterovirus 71-infected mice. Deferoxamine, a marine microbial natural product, compensated for the decreased levels of B cells caused by enterovirus 71 infection. The neutralizing antibody titer was also improved after deferoxamine treatment. Furthermore, deferoxamine relieved symptoms and reduced mortality and muscle damage caused by enterovirus 71 infection. This work suggested that deferoxamine has the potential for further development as a B cell-immunomodulator against enterovirus 71.http://www.mdpi.com/1660-3397/12/7/4086deferoxamineenterovirus 71handfoot and mouth diseaseB cells |
| spellingShingle | Yajun Yang Jing Ma Jinghui Xiu Lin Bai Feifei Guan Li Zhang Jiangning Liu Lianfeng Zhang Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice Marine Drugs deferoxamine enterovirus 71 hand foot and mouth disease B cells |
| title | Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice |
| title_full | Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice |
| title_fullStr | Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice |
| title_full_unstemmed | Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice |
| title_short | Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice |
| title_sort | deferoxamine compensates for decreases in b cell counts and reduces mortality in enterovirus 71 infected mice |
| topic | deferoxamine enterovirus 71 hand foot and mouth disease B cells |
| url | http://www.mdpi.com/1660-3397/12/7/4086 |
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