Cerebrovascular Compliance Within the Rigid Confines of the Skull
Pulsatile blood flow is generally mediated by the compliance of blood vessels whereby they distend locally and momentarily to accommodate the passage of the pressure wave. This freedom of the blood vessels to exercise their compliance may be suppressed within the confines of the rigid skull. The eff...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.00940/full |
| _version_ | 1819078907417067520 |
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| author | Mair Zamir Mair Zamir M. Erin Moir Stephen A. Klassen Christopher S. Balestrini J. Kevin Shoemaker J. Kevin Shoemaker |
| author_facet | Mair Zamir Mair Zamir M. Erin Moir Stephen A. Klassen Christopher S. Balestrini J. Kevin Shoemaker J. Kevin Shoemaker |
| author_sort | Mair Zamir |
| collection | DOAJ |
| description | Pulsatile blood flow is generally mediated by the compliance of blood vessels whereby they distend locally and momentarily to accommodate the passage of the pressure wave. This freedom of the blood vessels to exercise their compliance may be suppressed within the confines of the rigid skull. The effect of this on the mechanics of pulsatile blood flow within the cerebral circulation is not known, and the situation is compounded by experimental access difficulties. We present an approach which we have developed to overcome these difficulties in a study of the mechanics of pulsatile cerebral blood flow. The main finding is that while the innate compliance of cerebral vessels is indeed suppressed within the confines of the skull, this is compensated somewhat by compliance provided by other “extravascular” elements within the skull. The net result is what we have termed “intracranial compliance,” which we argue is more pertinent to the mechanics of pulsatile cerebral blood flow than is intracranial pressure. |
| first_indexed | 2024-12-21T19:20:33Z |
| format | Article |
| id | doaj.art-370caa3eaa0e4636ab5c1227c6422156 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-21T19:20:33Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-370caa3eaa0e4636ab5c1227c64221562022-12-21T18:52:58ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-07-01910.3389/fphys.2018.00940393338Cerebrovascular Compliance Within the Rigid Confines of the SkullMair Zamir0Mair Zamir1M. Erin Moir2Stephen A. Klassen3Christopher S. Balestrini4J. Kevin Shoemaker5J. Kevin Shoemaker6Department of Applied Mathematics, The University of Western Ontario, London, ON, CanadaDepartment of Medical Biophysics, The University of Western Ontario, London, ON, CanadaSchool of Kinesiology, The University of Western Ontario, London, ON, CanadaSchool of Kinesiology, The University of Western Ontario, London, ON, CanadaSchool of Kinesiology, The University of Western Ontario, London, ON, CanadaSchool of Kinesiology, The University of Western Ontario, London, ON, CanadaDepartment of Physiology and Pharmacology, The University of Western Ontario, London, ON, CanadaPulsatile blood flow is generally mediated by the compliance of blood vessels whereby they distend locally and momentarily to accommodate the passage of the pressure wave. This freedom of the blood vessels to exercise their compliance may be suppressed within the confines of the rigid skull. The effect of this on the mechanics of pulsatile blood flow within the cerebral circulation is not known, and the situation is compounded by experimental access difficulties. We present an approach which we have developed to overcome these difficulties in a study of the mechanics of pulsatile cerebral blood flow. The main finding is that while the innate compliance of cerebral vessels is indeed suppressed within the confines of the skull, this is compensated somewhat by compliance provided by other “extravascular” elements within the skull. The net result is what we have termed “intracranial compliance,” which we argue is more pertinent to the mechanics of pulsatile cerebral blood flow than is intracranial pressure.https://www.frontiersin.org/article/10.3389/fphys.2018.00940/fullcerebral blood flowcerebrovascular complianceintracranial complianceintracranial pressurepulsatile blood flow |
| spellingShingle | Mair Zamir Mair Zamir M. Erin Moir Stephen A. Klassen Christopher S. Balestrini J. Kevin Shoemaker J. Kevin Shoemaker Cerebrovascular Compliance Within the Rigid Confines of the Skull Frontiers in Physiology cerebral blood flow cerebrovascular compliance intracranial compliance intracranial pressure pulsatile blood flow |
| title | Cerebrovascular Compliance Within the Rigid Confines of the Skull |
| title_full | Cerebrovascular Compliance Within the Rigid Confines of the Skull |
| title_fullStr | Cerebrovascular Compliance Within the Rigid Confines of the Skull |
| title_full_unstemmed | Cerebrovascular Compliance Within the Rigid Confines of the Skull |
| title_short | Cerebrovascular Compliance Within the Rigid Confines of the Skull |
| title_sort | cerebrovascular compliance within the rigid confines of the skull |
| topic | cerebral blood flow cerebrovascular compliance intracranial compliance intracranial pressure pulsatile blood flow |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.00940/full |
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