FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY
To evaluate the immunity indexes in the children who were born with bronchopulmonary dysplasia (BPD) of varying severity at very early delivery terms (22-27 weeks), dynamic examinations were performed in 35 infants: 17 children were with severe BPD; 18, with mild-severity and moderately severe BPD....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2019-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/1825 |
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| author | G. N. Chistyakova I. I. Remizova L. S. Ustyantseva K. P. Shamova S. V. Bychkova M. A. Botskovskaya I. A. Gazieva |
| author_facet | G. N. Chistyakova I. I. Remizova L. S. Ustyantseva K. P. Shamova S. V. Bychkova M. A. Botskovskaya I. A. Gazieva |
| author_sort | G. N. Chistyakova |
| collection | DOAJ |
| description | To evaluate the immunity indexes in the children who were born with bronchopulmonary dysplasia (BPD) of varying severity at very early delivery terms (22-27 weeks), dynamic examinations were performed in 35 infants: 17 children were with severe BPD; 18, with mild-severity and moderately severe BPD. The comparison group consisted of seven children born at 22-27 weeks of gestational age without signs of BPD. Relative numbers of lymphocyte subpopulations (CD3+, CD4+, CD8+, CD19+, CD16+CD56+, CD4+CD25+), and monocytes (CD14+CD64+, CD14+HLA-DR+) were determined by flow cytometry. The level of cytokines (IL-6, IL-8, IL-4) was measured by enzyme immunoassay technique. The features of immune status in children with BPD of severe, mild and moderate severity were discerned. It was found that the predictors of severe BPD development in the children born at very early terms, are: increased content of IL-8 at birth and at the age of 1 month, reduced level of expression on monocytes (CD64, HLA-DR) on the 1 month of life, and CD14+CD64+ cells at 38-40 weeks post conception. The revealed features of immune status in newborns with BPD can be used to assess the effectiveness of the therapy, which requires further research in this direction. |
| first_indexed | 2024-03-08T05:48:32Z |
| format | Article |
| id | doaj.art-370d09e41d704fc8a10ab3e3fa31f2cd |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:18:02Z |
| publishDate | 2019-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-370d09e41d704fc8a10ab3e3fa31f2cd2025-03-11T17:59:10ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2019-07-0121351752610.15789/1563-0625-2019-3-517-5261172FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITYG. N. Chistyakova0I. I. Remizova1L. S. Ustyantseva2K. P. Shamova3S. V. Bychkova4M. A. Botskovskaya5I. A. Gazieva6Ural Research Institute for Maternal and Child CareUral Research Institute for Maternal and Child CareUral Research Institute for Maternal and Child CareUral Research Institute for Maternal and Child CareUral Research Institute for Maternal and Child CareUral Research Institute for Maternal and Child CareUral Research Institute for Maternal and Child CareTo evaluate the immunity indexes in the children who were born with bronchopulmonary dysplasia (BPD) of varying severity at very early delivery terms (22-27 weeks), dynamic examinations were performed in 35 infants: 17 children were with severe BPD; 18, with mild-severity and moderately severe BPD. The comparison group consisted of seven children born at 22-27 weeks of gestational age without signs of BPD. Relative numbers of lymphocyte subpopulations (CD3+, CD4+, CD8+, CD19+, CD16+CD56+, CD4+CD25+), and monocytes (CD14+CD64+, CD14+HLA-DR+) were determined by flow cytometry. The level of cytokines (IL-6, IL-8, IL-4) was measured by enzyme immunoassay technique. The features of immune status in children with BPD of severe, mild and moderate severity were discerned. It was found that the predictors of severe BPD development in the children born at very early terms, are: increased content of IL-8 at birth and at the age of 1 month, reduced level of expression on monocytes (CD64, HLA-DR) on the 1 month of life, and CD14+CD64+ cells at 38-40 weeks post conception. The revealed features of immune status in newborns with BPD can be used to assess the effectiveness of the therapy, which requires further research in this direction.https://www.mimmun.ru/mimmun/article/view/1825extremely low body weightbronchopulmonary dysplasiaadaptive immunityinnate immunity |
| spellingShingle | G. N. Chistyakova I. I. Remizova L. S. Ustyantseva K. P. Shamova S. V. Bychkova M. A. Botskovskaya I. A. Gazieva FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY Медицинская иммунология extremely low body weight bronchopulmonary dysplasia adaptive immunity innate immunity |
| title | FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY |
| title_full | FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY |
| title_fullStr | FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY |
| title_full_unstemmed | FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY |
| title_short | FEATURES OF IMMUNE RESPONSE IN PRETERM BABIES WITH BRONCHOPULMONARY DISPLASIA OF VARIOUS SEVERITY |
| title_sort | features of immune response in preterm babies with bronchopulmonary displasia of various severity |
| topic | extremely low body weight bronchopulmonary dysplasia adaptive immunity innate immunity |
| url | https://www.mimmun.ru/mimmun/article/view/1825 |
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