Myocarditis/pericarditis following vaccination with BNT162b2, CoronaVac, and ChAdOx1 among adolescent and adult in Malaysia
This study evaluates 21-day risk of myocarditis/pericarditis following COVID-19 vaccination among those aged 12 years and older in Malaysia. We used data from nationwide COVID-19 vaccine registry linked to hospital episode database to identify individuals vaccinated with BNT162b2, CoronaVac, or ChAd...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Vaccine: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S259013622300044X |
| _version_ | 1797752937208872960 |
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| author | Norazida Ab Rahman Ming Tsuey Lim Fei Yee Lee Emelyne Bani Anak Jam Kalaiarasu M Peariasamy Sheamini Sivasampu |
| author_facet | Norazida Ab Rahman Ming Tsuey Lim Fei Yee Lee Emelyne Bani Anak Jam Kalaiarasu M Peariasamy Sheamini Sivasampu |
| author_sort | Norazida Ab Rahman |
| collection | DOAJ |
| description | This study evaluates 21-day risk of myocarditis/pericarditis following COVID-19 vaccination among those aged 12 years and older in Malaysia. We used data from nationwide COVID-19 vaccine registry linked to hospital episode database to identify individuals vaccinated with BNT162b2, CoronaVac, or ChAdOx1 and hospitalised for myocarditis/pericarditis between 1 February 2021 and 28 February 2022. There were 87 myocarditis/pericarditis cases identified within 1–21 days after vaccination. Most cases were reported following BNT16262 vaccination (77.0%) with absolute risk of 0.33 cases/100,000 vaccinated persons or 1.73 per million doses administered. Highest risk was observed following second dose and in younger, male individuals. The risk of myocarditis/pericarditis following CoronaVac and ChAdOx1 were much lower compared to BNT162b2. The findings on higher risk observed among younger following mRNA vaccine were consistent with literature and important for targeted surveillance. |
| first_indexed | 2024-03-12T17:11:05Z |
| format | Article |
| id | doaj.art-370d789e871c47dfbe9c8369897a39e2 |
| institution | Directory Open Access Journal |
| issn | 2590-1362 |
| language | English |
| last_indexed | 2024-03-12T17:11:05Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Vaccine: X |
| spelling | doaj.art-370d789e871c47dfbe9c8369897a39e22023-08-06T04:38:09ZengElsevierVaccine: X2590-13622023-08-0114100303Myocarditis/pericarditis following vaccination with BNT162b2, CoronaVac, and ChAdOx1 among adolescent and adult in MalaysiaNorazida Ab Rahman0Ming Tsuey Lim1Fei Yee Lee2Emelyne Bani Anak Jam3Kalaiarasu M Peariasamy4Sheamini Sivasampu5Institute for Clinical Research, National Institutes of Health, Selangor, Malaysia; Corresponding author at: Institute for Clinical Research, Block B4, National Institutes of Health, No 1, Jalan Setia Murni U13/52, 40170 Shah Alam, Selangor, Malaysia.Institute for Clinical Research, National Institutes of Health, Selangor, MalaysiaClinical Research Centre, Selayang Hospital, Ministry of Health, Selangor, MalaysiaClinical Research Centre, Queen Elizabeth II Hospital, Ministry of Health, Sabah, MalaysiaInstitute for Clinical Research, National Institutes of Health, Selangor, MalaysiaInstitute for Clinical Research, National Institutes of Health, Selangor, MalaysiaThis study evaluates 21-day risk of myocarditis/pericarditis following COVID-19 vaccination among those aged 12 years and older in Malaysia. We used data from nationwide COVID-19 vaccine registry linked to hospital episode database to identify individuals vaccinated with BNT162b2, CoronaVac, or ChAdOx1 and hospitalised for myocarditis/pericarditis between 1 February 2021 and 28 February 2022. There were 87 myocarditis/pericarditis cases identified within 1–21 days after vaccination. Most cases were reported following BNT16262 vaccination (77.0%) with absolute risk of 0.33 cases/100,000 vaccinated persons or 1.73 per million doses administered. Highest risk was observed following second dose and in younger, male individuals. The risk of myocarditis/pericarditis following CoronaVac and ChAdOx1 were much lower compared to BNT162b2. The findings on higher risk observed among younger following mRNA vaccine were consistent with literature and important for targeted surveillance.http://www.sciencedirect.com/science/article/pii/S259013622300044XCOVID-19 vaccineMyocarditisPericarditisAdverse effects |
| spellingShingle | Norazida Ab Rahman Ming Tsuey Lim Fei Yee Lee Emelyne Bani Anak Jam Kalaiarasu M Peariasamy Sheamini Sivasampu Myocarditis/pericarditis following vaccination with BNT162b2, CoronaVac, and ChAdOx1 among adolescent and adult in Malaysia Vaccine: X COVID-19 vaccine Myocarditis Pericarditis Adverse effects |
| title | Myocarditis/pericarditis following vaccination with BNT162b2, CoronaVac, and ChAdOx1 among adolescent and adult in Malaysia |
| title_full | Myocarditis/pericarditis following vaccination with BNT162b2, CoronaVac, and ChAdOx1 among adolescent and adult in Malaysia |
| title_fullStr | Myocarditis/pericarditis following vaccination with BNT162b2, CoronaVac, and ChAdOx1 among adolescent and adult in Malaysia |
| title_full_unstemmed | Myocarditis/pericarditis following vaccination with BNT162b2, CoronaVac, and ChAdOx1 among adolescent and adult in Malaysia |
| title_short | Myocarditis/pericarditis following vaccination with BNT162b2, CoronaVac, and ChAdOx1 among adolescent and adult in Malaysia |
| title_sort | myocarditis pericarditis following vaccination with bnt162b2 coronavac and chadox1 among adolescent and adult in malaysia |
| topic | COVID-19 vaccine Myocarditis Pericarditis Adverse effects |
| url | http://www.sciencedirect.com/science/article/pii/S259013622300044X |
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