Correlation Analysis between Neutrophil-to-lymphocyte Ratio and the Risk of Malnutrition in Stage IV Primary Lung Cancer
Background and objective Malnutrition is commonly associated with poor prognosis in patients with malignant tumors. The neutrophil-to-lymphocyte ratio (NLR) is an indicator of inflammation in the body and predicts the risk of malnutrition in a variety of diseases; however, its association with malnu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2024-03-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2024.106.06 |
| _version_ | 1797217291099701248 |
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| author | Ping XIAO Hai PAN Qing MA Liping SONG Diansheng ZHONG |
| author_facet | Ping XIAO Hai PAN Qing MA Liping SONG Diansheng ZHONG |
| author_sort | Ping XIAO |
| collection | DOAJ |
| description | Background and objective Malnutrition is commonly associated with poor prognosis in patients with malignant tumors. The neutrophil-to-lymphocyte ratio (NLR) is an indicator of inflammation in the body and predicts the risk of malnutrition in a variety of diseases; however, its association with malnutrition in lung cancer patients is unclear. The aim of this study is to clarify the association between NLR and nutritional status in stage IV primary lung cancer and to further determine the optimal NLR cut-off that best predicts the risk of malnutrition. Methods A retrospective analysis of 209 patients admitted to the Department of Medical Oncology, Tianjin Medical University General Hospital with a primary diagnosis of stage IV lung cancer from May 2019 to February 2021 was performed, and the nutritional risk screening 2002 (NRS 2002) was used to examine their nutritional status. Patient demographic information, pathology, Karnofsky performance status (KPS) score, body mass index (BMI), comorbidities and clinical biochemical indicators were also included. The correlation between NLR and NRS 2002 was investigated. Receiver operating characteristic (ROC) curve was used to determine the best NLR cut-off predi cting malnutrition risk. Multivariable Logistic regression was used to assess the association between NLR and malnutrition risk. Results The rate of patients with stage IV primary lung cancer at nutritional risk was 36.36% (76/209). A significant positive correlation was observed between NLR values and NRS 2002 risk score (r=0.765, P<0.001). The ROC curve analysis indicated that an NLR of 3.94 was the optimal cut-off for predicting malnutrition risk (area under the curve=0.747, 95%CI: 0.678-0.815, P<0.001), which showed a sensitivity of 55%, a specificity of 86%, a positive predictive value of 68%, and a negative predictive value of 77%. Patients in the NLR>3.94 group had a significantly higher risk of malnutrition compared to those in the NLR≤3.94 group (69.49% vs 23.33%, P<0.001). Furthermore, NLR was identified as a risk factor for malnutrition in stage IV primary lung cancer patients. Conclusion NLR is associated with the risk of malnutrition in stage IV primary lung cancer, and NLR can be used as one of the indicators for screening nutritional risk in patients with stage IV primary lung cancer. |
| first_indexed | 2024-04-24T11:59:31Z |
| format | Article |
| id | doaj.art-370f4223c8e3444ba8d5e062509584c3 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-04-24T11:59:31Z |
| publishDate | 2024-03-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-370f4223c8e3444ba8d5e062509584c32024-04-09T01:52:31ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872024-03-0127319319810.3779/j.issn.1009-3419.2024.106.06Correlation Analysis between Neutrophil-to-lymphocyte Ratio
and the Risk of Malnutrition in Stage IV Primary Lung CancerPing XIAO0Hai PAN1Qing MA2Liping SONG3Diansheng ZHONG4Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300052, ChinaBackground and objective Malnutrition is commonly associated with poor prognosis in patients with malignant tumors. The neutrophil-to-lymphocyte ratio (NLR) is an indicator of inflammation in the body and predicts the risk of malnutrition in a variety of diseases; however, its association with malnutrition in lung cancer patients is unclear. The aim of this study is to clarify the association between NLR and nutritional status in stage IV primary lung cancer and to further determine the optimal NLR cut-off that best predicts the risk of malnutrition. Methods A retrospective analysis of 209 patients admitted to the Department of Medical Oncology, Tianjin Medical University General Hospital with a primary diagnosis of stage IV lung cancer from May 2019 to February 2021 was performed, and the nutritional risk screening 2002 (NRS 2002) was used to examine their nutritional status. Patient demographic information, pathology, Karnofsky performance status (KPS) score, body mass index (BMI), comorbidities and clinical biochemical indicators were also included. The correlation between NLR and NRS 2002 was investigated. Receiver operating characteristic (ROC) curve was used to determine the best NLR cut-off predi cting malnutrition risk. Multivariable Logistic regression was used to assess the association between NLR and malnutrition risk. Results The rate of patients with stage IV primary lung cancer at nutritional risk was 36.36% (76/209). A significant positive correlation was observed between NLR values and NRS 2002 risk score (r=0.765, P<0.001). The ROC curve analysis indicated that an NLR of 3.94 was the optimal cut-off for predicting malnutrition risk (area under the curve=0.747, 95%CI: 0.678-0.815, P<0.001), which showed a sensitivity of 55%, a specificity of 86%, a positive predictive value of 68%, and a negative predictive value of 77%. Patients in the NLR>3.94 group had a significantly higher risk of malnutrition compared to those in the NLR≤3.94 group (69.49% vs 23.33%, P<0.001). Furthermore, NLR was identified as a risk factor for malnutrition in stage IV primary lung cancer patients. Conclusion NLR is associated with the risk of malnutrition in stage IV primary lung cancer, and NLR can be used as one of the indicators for screening nutritional risk in patients with stage IV primary lung cancer.http://dx.doi.org/10.3779/j.issn.1009-3419.2024.106.06malnutritionlung neoplasmsneutrophil-to-lymphocyte ratio |
| spellingShingle | Ping XIAO Hai PAN Qing MA Liping SONG Diansheng ZHONG Correlation Analysis between Neutrophil-to-lymphocyte Ratio and the Risk of Malnutrition in Stage IV Primary Lung Cancer Chinese Journal of Lung Cancer malnutrition lung neoplasms neutrophil-to-lymphocyte ratio |
| title | Correlation Analysis between Neutrophil-to-lymphocyte Ratio
and the Risk of Malnutrition in Stage IV Primary Lung Cancer |
| title_full | Correlation Analysis between Neutrophil-to-lymphocyte Ratio
and the Risk of Malnutrition in Stage IV Primary Lung Cancer |
| title_fullStr | Correlation Analysis between Neutrophil-to-lymphocyte Ratio
and the Risk of Malnutrition in Stage IV Primary Lung Cancer |
| title_full_unstemmed | Correlation Analysis between Neutrophil-to-lymphocyte Ratio
and the Risk of Malnutrition in Stage IV Primary Lung Cancer |
| title_short | Correlation Analysis between Neutrophil-to-lymphocyte Ratio
and the Risk of Malnutrition in Stage IV Primary Lung Cancer |
| title_sort | correlation analysis between neutrophil to lymphocyte ratio
and the risk of malnutrition in stage iv primary lung cancer |
| topic | malnutrition lung neoplasms neutrophil-to-lymphocyte ratio |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2024.106.06 |
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