Platelet Membrane–Encapsulated MSNs Loaded with SS31 Peptide Alleviate Myocardial Ischemia-Reperfusion Injury
Clinically, antioxidant therapy is a potential strategy for myocardial ischemia-reperfusion injury (MI/RI), a common complication of acute myocardial ischemia. The H-D-Arg-Dmt-Ly-Phe-NH<sub>2</sub> (SS31) peptide is shown to have amazing antioxidant properties, but its utilization is lim...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/13/4/181 |
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| author | Zaiyuan Zhang Zhong Chen Ling Yang Jian Zhang Yubo Li Chengming Li Rui Wang Xue Wang Shuo Huang Yonghe Hu Jianyou Shi Wenjing Xiao |
| author_facet | Zaiyuan Zhang Zhong Chen Ling Yang Jian Zhang Yubo Li Chengming Li Rui Wang Xue Wang Shuo Huang Yonghe Hu Jianyou Shi Wenjing Xiao |
| author_sort | Zaiyuan Zhang |
| collection | DOAJ |
| description | Clinically, antioxidant therapy is a potential strategy for myocardial ischemia-reperfusion injury (MI/RI), a common complication of acute myocardial ischemia. The H-D-Arg-Dmt-Ly-Phe-NH<sub>2</sub> (SS31) peptide is shown to have amazing antioxidant properties, but its utilization is limited by the peptide characteristics, such as the destruction by proteases and rapid metabolism. Silica nanoparticles (MSNs) comprise an excellent material for peptide delivery, owing to the protection effect relating to peptides. Moreover, platelet membrane (PLTM) is shown to be advantageous as a coat for nanosystems because of its specific protein composition, such that a PLTM-coated nanosystem has a stealth effect in vivo, able to target injury in the cardiovascular system. Based on this feature, we designed and prepared a novel nanocarrier to target SS31 delivery. This carrier is encapsulated by a platelet membrane and loaded with SS31 peptide into MSNs. The results reveal that this delivery system can target SS31 to the injured cardiovascular site, exert antioxidant function, and alleviate MI/RI. |
| first_indexed | 2024-03-09T16:15:38Z |
| format | Article |
| id | doaj.art-371102cad4c442ddac8b0ae7bc1700f3 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T16:15:38Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-371102cad4c442ddac8b0ae7bc1700f32023-11-24T15:49:01ZengMDPI AGJournal of Functional Biomaterials2079-49832022-10-0113418110.3390/jfb13040181Platelet Membrane–Encapsulated MSNs Loaded with SS31 Peptide Alleviate Myocardial Ischemia-Reperfusion InjuryZaiyuan Zhang0Zhong Chen1Ling Yang2Jian Zhang3Yubo Li4Chengming Li5Rui Wang6Xue Wang7Shuo Huang8Yonghe Hu9Jianyou Shi10Wenjing Xiao11College of Medicine, Southwest Jiaotong University, Chengdu 610031, ChinaDepartment of Ultrasound, The General Hospital of Western Theater Command of PLA, Chengdu 610083, ChinaSchool of Clinical Medicine, Chengdu University of TCM, Chengdu 610072, ChinaCollege of Medicine, Southwest Jiaotong University, Chengdu 610031, ChinaCollege of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou 646000, ChinaSchool of Clinical Medicine, Chengdu University of TCM, Chengdu 610072, ChinaDepartment of Ultrasound, The General Hospital of Western Theater Command of PLA, Chengdu 610083, ChinaSchool of Clinical Medicine, Chengdu University of TCM, Chengdu 610072, ChinaSchool of Clinical Medicine, Chengdu University of TCM, Chengdu 610072, ChinaCollege of Medicine, Southwest Jiaotong University, Chengdu 610031, ChinaPersonalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, ChinaDepartment of Pharmacy, The General Hospital of Western Theater Command of PLA, Chengdu 610083, ChinaClinically, antioxidant therapy is a potential strategy for myocardial ischemia-reperfusion injury (MI/RI), a common complication of acute myocardial ischemia. The H-D-Arg-Dmt-Ly-Phe-NH<sub>2</sub> (SS31) peptide is shown to have amazing antioxidant properties, but its utilization is limited by the peptide characteristics, such as the destruction by proteases and rapid metabolism. Silica nanoparticles (MSNs) comprise an excellent material for peptide delivery, owing to the protection effect relating to peptides. Moreover, platelet membrane (PLTM) is shown to be advantageous as a coat for nanosystems because of its specific protein composition, such that a PLTM-coated nanosystem has a stealth effect in vivo, able to target injury in the cardiovascular system. Based on this feature, we designed and prepared a novel nanocarrier to target SS31 delivery. This carrier is encapsulated by a platelet membrane and loaded with SS31 peptide into MSNs. The results reveal that this delivery system can target SS31 to the injured cardiovascular site, exert antioxidant function, and alleviate MI/RI.https://www.mdpi.com/2079-4983/13/4/181ischemia-reperfusionoxidative damagemitochondria-mediated apoptosisdrug deliveryplatelet membrane |
| spellingShingle | Zaiyuan Zhang Zhong Chen Ling Yang Jian Zhang Yubo Li Chengming Li Rui Wang Xue Wang Shuo Huang Yonghe Hu Jianyou Shi Wenjing Xiao Platelet Membrane–Encapsulated MSNs Loaded with SS31 Peptide Alleviate Myocardial Ischemia-Reperfusion Injury Journal of Functional Biomaterials ischemia-reperfusion oxidative damage mitochondria-mediated apoptosis drug delivery platelet membrane |
| title | Platelet Membrane–Encapsulated MSNs Loaded with SS31 Peptide Alleviate Myocardial Ischemia-Reperfusion Injury |
| title_full | Platelet Membrane–Encapsulated MSNs Loaded with SS31 Peptide Alleviate Myocardial Ischemia-Reperfusion Injury |
| title_fullStr | Platelet Membrane–Encapsulated MSNs Loaded with SS31 Peptide Alleviate Myocardial Ischemia-Reperfusion Injury |
| title_full_unstemmed | Platelet Membrane–Encapsulated MSNs Loaded with SS31 Peptide Alleviate Myocardial Ischemia-Reperfusion Injury |
| title_short | Platelet Membrane–Encapsulated MSNs Loaded with SS31 Peptide Alleviate Myocardial Ischemia-Reperfusion Injury |
| title_sort | platelet membrane encapsulated msns loaded with ss31 peptide alleviate myocardial ischemia reperfusion injury |
| topic | ischemia-reperfusion oxidative damage mitochondria-mediated apoptosis drug delivery platelet membrane |
| url | https://www.mdpi.com/2079-4983/13/4/181 |
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