A Capra hircus chromosome 19 locus linked to milk production influences mammary conformation
Abstract Background Economically important milk production traits including milk volume, milk fat and protein yield vary considerably across dairy goats in New Zealand. A significant portion of the variation is attributable to genetic variation. Discovery of genetic markers linked to milk production...
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | Journal of Animal Science and Biotechnology |
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| Online Access: | https://doi.org/10.1186/s40104-021-00667-y |
| _version_ | 1818286729387311104 |
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| author | Andrew Jiang Alex Ankersmit-Udy Sally-Anne Turner Megan Scholtens Mathew D. Littlejohn Nicolas Lopez-Villalobos Colin G. Proser Russell G. Snell Klaus Lehnert |
| author_facet | Andrew Jiang Alex Ankersmit-Udy Sally-Anne Turner Megan Scholtens Mathew D. Littlejohn Nicolas Lopez-Villalobos Colin G. Proser Russell G. Snell Klaus Lehnert |
| author_sort | Andrew Jiang |
| collection | DOAJ |
| description | Abstract Background Economically important milk production traits including milk volume, milk fat and protein yield vary considerably across dairy goats in New Zealand. A significant portion of the variation is attributable to genetic variation. Discovery of genetic markers linked to milk production traits can be utilised to drive selection of high-performance animals. A previously reported genome wide association study across dairy goats in New Zealand identified a quantitative trait locus (QTL) located on chromosome 19. The most significantly associated single nucleotide polymorphism (SNP) marker for this locus is located at position 26,610,610 (SNP marker rs268292132). This locus is associated with multiple milk production traits including fat, protein and volume. The predicted effect of selection for the beneficial haplotype would result in an average production increase of 2.2 kg fat, 1.9 kg protein and 73.6 kg milk yield. An outstanding question was whether selection for the beneficial allele would co-select for any negative pleiotropic effects. An adverse relationship between milk production and udder health traits has been reported at this locus. Therefore, a genome wide association study was undertaken looking for loci associated with udder traits. Results The QTL and production associated marker rs268292132 was identified in this study to also be associated with several goat udder traits including udder depth (UD), fore udder attachment (FUA) and rear udder attachment (RUA). Our study replicates the negative relationship between production and udder traits with the high production allele at position 19:26,610,610 (SNP marker rs268292132) associated with an adverse change in UD, FUA and RUA. Conclusions Our study has confirmed the negative relationship between udder traits and production traits in the NZ goat population. We have found that the frequency of the high production allele is relatively high in the NZ goat population, indicating that its effect on udder conformation is not significantly detrimental on animal health. It will however be important to monitor udder conformation as the chromosome 19 locus is progressively implemented for marker assisted selection. It will also be of interest to determine if the gene underlying the production QTL has a direct effect on mammary gland morphology or whether the changes observed are a consequence of the increased milk volume. |
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| id | doaj.art-37111db90e9f4fd280d879d1c31e449d |
| institution | Directory Open Access Journal |
| issn | 2049-1891 |
| language | English |
| last_indexed | 2024-12-13T01:29:13Z |
| publishDate | 2022-02-01 |
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| series | Journal of Animal Science and Biotechnology |
| spelling | doaj.art-37111db90e9f4fd280d879d1c31e449d2022-12-22T00:04:03ZengBMCJournal of Animal Science and Biotechnology2049-18912022-02-0113111010.1186/s40104-021-00667-yA Capra hircus chromosome 19 locus linked to milk production influences mammary conformationAndrew Jiang0Alex Ankersmit-Udy1Sally-Anne Turner2Megan Scholtens3Mathew D. Littlejohn4Nicolas Lopez-Villalobos5Colin G. Proser6Russell G. Snell7Klaus Lehnert8Applied Translational Genetics Group, School of Biological Sciences, The University of AucklandApplied Translational Genetics Group, School of Biological Sciences, The University of AucklandDairy Goat Co-operativeCawthron InstituteAL Rae Centre of Genetics and Breeding, Massey UniversityDairy Cattle Breeding and Genetics, School of Agriculture & Environment, Massey UniversityDairy Goat Co-operativeApplied Translational Genetics Group, School of Biological Sciences, The University of AucklandApplied Translational Genetics Group, School of Biological Sciences, The University of AucklandAbstract Background Economically important milk production traits including milk volume, milk fat and protein yield vary considerably across dairy goats in New Zealand. A significant portion of the variation is attributable to genetic variation. Discovery of genetic markers linked to milk production traits can be utilised to drive selection of high-performance animals. A previously reported genome wide association study across dairy goats in New Zealand identified a quantitative trait locus (QTL) located on chromosome 19. The most significantly associated single nucleotide polymorphism (SNP) marker for this locus is located at position 26,610,610 (SNP marker rs268292132). This locus is associated with multiple milk production traits including fat, protein and volume. The predicted effect of selection for the beneficial haplotype would result in an average production increase of 2.2 kg fat, 1.9 kg protein and 73.6 kg milk yield. An outstanding question was whether selection for the beneficial allele would co-select for any negative pleiotropic effects. An adverse relationship between milk production and udder health traits has been reported at this locus. Therefore, a genome wide association study was undertaken looking for loci associated with udder traits. Results The QTL and production associated marker rs268292132 was identified in this study to also be associated with several goat udder traits including udder depth (UD), fore udder attachment (FUA) and rear udder attachment (RUA). Our study replicates the negative relationship between production and udder traits with the high production allele at position 19:26,610,610 (SNP marker rs268292132) associated with an adverse change in UD, FUA and RUA. Conclusions Our study has confirmed the negative relationship between udder traits and production traits in the NZ goat population. We have found that the frequency of the high production allele is relatively high in the NZ goat population, indicating that its effect on udder conformation is not significantly detrimental on animal health. It will however be important to monitor udder conformation as the chromosome 19 locus is progressively implemented for marker assisted selection. It will also be of interest to determine if the gene underlying the production QTL has a direct effect on mammary gland morphology or whether the changes observed are a consequence of the increased milk volume.https://doi.org/10.1186/s40104-021-00667-yCapra hircusMilk productionPleiotropic effectsQuantitaive trait lociUdder conformation |
| spellingShingle | Andrew Jiang Alex Ankersmit-Udy Sally-Anne Turner Megan Scholtens Mathew D. Littlejohn Nicolas Lopez-Villalobos Colin G. Proser Russell G. Snell Klaus Lehnert A Capra hircus chromosome 19 locus linked to milk production influences mammary conformation Journal of Animal Science and Biotechnology Capra hircus Milk production Pleiotropic effects Quantitaive trait loci Udder conformation |
| title | A Capra hircus chromosome 19 locus linked to milk production influences mammary conformation |
| title_full | A Capra hircus chromosome 19 locus linked to milk production influences mammary conformation |
| title_fullStr | A Capra hircus chromosome 19 locus linked to milk production influences mammary conformation |
| title_full_unstemmed | A Capra hircus chromosome 19 locus linked to milk production influences mammary conformation |
| title_short | A Capra hircus chromosome 19 locus linked to milk production influences mammary conformation |
| title_sort | capra hircus chromosome 19 locus linked to milk production influences mammary conformation |
| topic | Capra hircus Milk production Pleiotropic effects Quantitaive trait loci Udder conformation |
| url | https://doi.org/10.1186/s40104-021-00667-y |
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