Acute Intoxication With Alcohol Reduces Trauma-Induced Proinflammatory Response and Barrier Breakdown in the Lung via the Wnt/β-Catenin Signaling Pathway

Acute Intoxication With Alcohol Reduces Trauma-Induced Proinflammatory Response and Barrier Breakdown in the Lung via the Wnt/β-Catenin Signaling Pathway

BackgroundTrauma is the third leading cause of mortality worldwide. Upon admission, up to 50% of traumatized patients are acutely intoxicated with alcohol, which might lead to aberrant immune responses. An excessive and uncontrolled inflammatory response to injury is associated with damage to trauma...

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Bibliographic Details
Main Authors: Laurens Noack, Katrin Bundkirchen, Baolin Xu, Severin Gylstorff, Yuzhuo Zhou, Kernt Köhler, Phatcharida Jantaree, Claudia Neunaber, Aleksander J. Nowak, Borna Relja
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
femur fracture
hemorrhagic shock
inflammation
pulmonary
ethanol
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.866925/full

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