Inhibition potential of phenolic constituents from the aerial parts of Tetrastigma hemsleyanum against soluble epoxide hydrolase and nitric oxide synthase
The aerial parts of Tetrastigma hemsleyanum (APTH) have been used as a functional tea in China. The purpose of the current study was to identify the bioactive constituents with inhibitory activity against soluble epoxide hydrolase (sEH) and inducible nitric oxide synthase (iNOS), which are jointly c...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Journal of Enzyme Inhibition and Medicinal Chemistry |
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| Online Access: | http://dx.doi.org/10.1080/14756366.2019.1584621 |
| _version_ | 1818031755457724416 |
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| author | Cai Yi Wang Sunggun Lee Hyun-Jae Jang Xiang Dong Su Heng-Shan Wang Young Ho Kim Seo Young Yang |
| author_facet | Cai Yi Wang Sunggun Lee Hyun-Jae Jang Xiang Dong Su Heng-Shan Wang Young Ho Kim Seo Young Yang |
| author_sort | Cai Yi Wang |
| collection | DOAJ |
| description | The aerial parts of Tetrastigma hemsleyanum (APTH) have been used as a functional tea in China. The purpose of the current study was to identify the bioactive constituents with inhibitory activity against soluble epoxide hydrolase (sEH) and inducible nitric oxide synthase (iNOS), which are jointly considered potential therapeutic targets for vascular system diseases. In the present study, 39 compounds (1–39) were isolated from the APTH. Among them, compounds 8, 10, 12, 16, 17, 19, and 32 displayed potential activities, with IC50 values ranging from 4.5 to 9.5 µM, respectively, and all in non-competitive inhibition mode. Compounds 5, 10, 12, 19, and 32 displayed potent iNOS inhibitory effects, with IC50 values ranging from 15.6 to 47.3 µM. The results obtained in this work contribute to a better understanding of the pharmacological activities of T. hemsleyanum and its potential application as a functional food. |
| first_indexed | 2024-12-10T05:56:31Z |
| format | Article |
| id | doaj.art-371454eb299f4b12866c243dd36d3bb4 |
| institution | Directory Open Access Journal |
| issn | 1475-6366 1475-6374 |
| language | English |
| last_indexed | 2024-12-10T05:56:31Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Enzyme Inhibition and Medicinal Chemistry |
| spelling | doaj.art-371454eb299f4b12866c243dd36d3bb42022-12-22T01:59:55ZengTaylor & Francis GroupJournal of Enzyme Inhibition and Medicinal Chemistry1475-63661475-63742019-01-0134175376010.1080/14756366.2019.15846211584621Inhibition potential of phenolic constituents from the aerial parts of Tetrastigma hemsleyanum against soluble epoxide hydrolase and nitric oxide synthaseCai Yi Wang0Sunggun Lee1Hyun-Jae Jang2Xiang Dong Su3Heng-Shan Wang4Young Ho Kim5Seo Young Yang6College of Pharmacy, Chungnam National UniversityCollege of Pharmacy, Chungnam National UniversityImmunoregulatory Material Research Center, Korea Research Institute of Bioscience and BiotechnologyCollege of Pharmacy, Chungnam National UniversityState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal UniversityCollege of Pharmacy, Chungnam National UniversityCollege of Pharmacy, Chungnam National UniversityThe aerial parts of Tetrastigma hemsleyanum (APTH) have been used as a functional tea in China. The purpose of the current study was to identify the bioactive constituents with inhibitory activity against soluble epoxide hydrolase (sEH) and inducible nitric oxide synthase (iNOS), which are jointly considered potential therapeutic targets for vascular system diseases. In the present study, 39 compounds (1–39) were isolated from the APTH. Among them, compounds 8, 10, 12, 16, 17, 19, and 32 displayed potential activities, with IC50 values ranging from 4.5 to 9.5 µM, respectively, and all in non-competitive inhibition mode. Compounds 5, 10, 12, 19, and 32 displayed potent iNOS inhibitory effects, with IC50 values ranging from 15.6 to 47.3 µM. The results obtained in this work contribute to a better understanding of the pharmacological activities of T. hemsleyanum and its potential application as a functional food.http://dx.doi.org/10.1080/14756366.2019.1584621tetrastigma hemsleyanumvitaceaephenolicssoluble epoxide hydrolasenitric oxide synthase |
| spellingShingle | Cai Yi Wang Sunggun Lee Hyun-Jae Jang Xiang Dong Su Heng-Shan Wang Young Ho Kim Seo Young Yang Inhibition potential of phenolic constituents from the aerial parts of Tetrastigma hemsleyanum against soluble epoxide hydrolase and nitric oxide synthase Journal of Enzyme Inhibition and Medicinal Chemistry tetrastigma hemsleyanum vitaceae phenolics soluble epoxide hydrolase nitric oxide synthase |
| title | Inhibition potential of phenolic constituents from the aerial parts of Tetrastigma hemsleyanum against soluble epoxide hydrolase and nitric oxide synthase |
| title_full | Inhibition potential of phenolic constituents from the aerial parts of Tetrastigma hemsleyanum against soluble epoxide hydrolase and nitric oxide synthase |
| title_fullStr | Inhibition potential of phenolic constituents from the aerial parts of Tetrastigma hemsleyanum against soluble epoxide hydrolase and nitric oxide synthase |
| title_full_unstemmed | Inhibition potential of phenolic constituents from the aerial parts of Tetrastigma hemsleyanum against soluble epoxide hydrolase and nitric oxide synthase |
| title_short | Inhibition potential of phenolic constituents from the aerial parts of Tetrastigma hemsleyanum against soluble epoxide hydrolase and nitric oxide synthase |
| title_sort | inhibition potential of phenolic constituents from the aerial parts of tetrastigma hemsleyanum against soluble epoxide hydrolase and nitric oxide synthase |
| topic | tetrastigma hemsleyanum vitaceae phenolics soluble epoxide hydrolase nitric oxide synthase |
| url | http://dx.doi.org/10.1080/14756366.2019.1584621 |
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