Probiotics and synbiotics may improve liver aminotransferases levels in non-alcoholic fatty liver disease patients
Non-alcoholic fatty liver disease (NAFLD) is defined as a spectrum of liver diseases ranging from simple steatosis to steatohepatitis (NASH). Alterations in intestinal microbiota and inflammatory response may play a key role in disease progression and development of complications in liver diseases,...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-09-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119312463 |
| _version_ | 1819107296600391680 |
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| author | Caroline Buss, R.D., Ph.D. Cristiane Valle-Tovo Suellen Miozzo Angelo Alves de Mattos |
| author_facet | Caroline Buss, R.D., Ph.D. Cristiane Valle-Tovo Suellen Miozzo Angelo Alves de Mattos |
| author_sort | Caroline Buss, R.D., Ph.D. |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is defined as a spectrum of liver diseases ranging from simple steatosis to steatohepatitis (NASH). Alterations in intestinal microbiota and inflammatory response may play a key role in disease progression and development of complications in liver diseases, mainly in cirrhosis and NASH. The aim of this study was to perform a systematic review on randomized clinical trials (RCTs) testing probiotics, prebiotics or both (synbiotics) in the treatment of NAFLD in adult patients. After the screening process, 9 full-text articles were included in the review and 6 studies were excluded. Three randomized controlled trials were finally included in the qualitative synthesis. All patients in all the 3 studies were randomized to receive different formulations of probiotics, synbiotics or placebo. Reductions in aminotransferases were observed in the treated group in 2 of the studies. However, in one study reductions were also detected in the control group. In conclusion, the available evidence precludes, for the moment, recommendations on the use of pre and probiotics in clinical practice. |
| first_indexed | 2024-12-22T02:51:47Z |
| format | Article |
| id | doaj.art-3715a37ae6a4448799288b0d2ac5f96f |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-22T02:51:47Z |
| publishDate | 2014-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-3715a37ae6a4448799288b0d2ac5f96f2022-12-21T18:41:22ZengElsevierAnnals of Hepatology1665-26812014-09-01135482488Probiotics and synbiotics may improve liver aminotransferases levels in non-alcoholic fatty liver disease patientsCaroline Buss, R.D., Ph.D.0Cristiane Valle-Tovo1Suellen Miozzo2Angelo Alves de Mattos3Nutrition Department, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre-RS, Brazil; Postgraduate Study Program in Medicine: Hepatology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre-RS, Brazil; Correspondence and reprint request:Postgraduate Study Program in Medicine: Hepatology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre-RS, BrazilPostgraduate Study Program in Medicine: Hepatology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre-RS, BrazilPostgraduate Study Program in Medicine: Hepatology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre-RS, BrazilNon-alcoholic fatty liver disease (NAFLD) is defined as a spectrum of liver diseases ranging from simple steatosis to steatohepatitis (NASH). Alterations in intestinal microbiota and inflammatory response may play a key role in disease progression and development of complications in liver diseases, mainly in cirrhosis and NASH. The aim of this study was to perform a systematic review on randomized clinical trials (RCTs) testing probiotics, prebiotics or both (synbiotics) in the treatment of NAFLD in adult patients. After the screening process, 9 full-text articles were included in the review and 6 studies were excluded. Three randomized controlled trials were finally included in the qualitative synthesis. All patients in all the 3 studies were randomized to receive different formulations of probiotics, synbiotics or placebo. Reductions in aminotransferases were observed in the treated group in 2 of the studies. However, in one study reductions were also detected in the control group. In conclusion, the available evidence precludes, for the moment, recommendations on the use of pre and probiotics in clinical practice.http://www.sciencedirect.com/science/article/pii/S1665268119312463NAFLDLiver steatosisPrebiotics |
| spellingShingle | Caroline Buss, R.D., Ph.D. Cristiane Valle-Tovo Suellen Miozzo Angelo Alves de Mattos Probiotics and synbiotics may improve liver aminotransferases levels in non-alcoholic fatty liver disease patients Annals of Hepatology NAFLD Liver steatosis Prebiotics |
| title | Probiotics and synbiotics may improve liver aminotransferases levels in non-alcoholic fatty liver disease patients |
| title_full | Probiotics and synbiotics may improve liver aminotransferases levels in non-alcoholic fatty liver disease patients |
| title_fullStr | Probiotics and synbiotics may improve liver aminotransferases levels in non-alcoholic fatty liver disease patients |
| title_full_unstemmed | Probiotics and synbiotics may improve liver aminotransferases levels in non-alcoholic fatty liver disease patients |
| title_short | Probiotics and synbiotics may improve liver aminotransferases levels in non-alcoholic fatty liver disease patients |
| title_sort | probiotics and synbiotics may improve liver aminotransferases levels in non alcoholic fatty liver disease patients |
| topic | NAFLD Liver steatosis Prebiotics |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119312463 |
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