Drug-induced lupus with leukocytoclastic vasculitis: a rare expression associated with adalimumab
AbstractTNF alpha antagonist-induced lupus-like syndrome is a rare condition which predominantly affects women (4:1). The average age of onset is 46-51 years. It occurs after exposure to TNF alpha antagonist and disappears after discontinuation of such agents. The pathogenic mechanism for developmen...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Dermatologia
2015-06-01
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| Series: | Anais Brasileiros de Dermatologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000700121&tlng=en |
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| author | Carolina Forte Amarante Livia Mendes Sabia Acedo Fátima Maria de Oliveira Rabay Benedito do Espírito Santo Campos Márcia Lanzoni de Alvarenga Lira Samuel Henrique Mandelbaum |
| author_facet | Carolina Forte Amarante Livia Mendes Sabia Acedo Fátima Maria de Oliveira Rabay Benedito do Espírito Santo Campos Márcia Lanzoni de Alvarenga Lira Samuel Henrique Mandelbaum |
| author_sort | Carolina Forte Amarante |
| collection | DOAJ |
| description | AbstractTNF alpha antagonist-induced lupus-like syndrome is a rare condition which predominantly affects women (4:1). The average age of onset is 46-51 years. It occurs after exposure to TNF alpha antagonist and disappears after discontinuation of such agents. The pathogenic mechanism for development of the TNF alpha antagonist-induced lupus-like syndrome is not fully defined. It is believed that the medication induces apoptosis, leading to an accumulation of nucleosomal antigens of apoptotic cells. This would cause autoantibodies to be produced by susceptible individuals. The most common cutaneous manifestations include maculopapular exanthem, malar rash, alopecia, photosensitivity and, more rarely, vasculitis. Extracutaneous manifestations include: fever, weight loss, arthritis or arthralgia, myositis and hematological abnormalities. Antinuclear antibody may be positive in 80% of cases and anti-histone antibody is considered a disease marker for TNF alpha antagonist-induced lupus-like syndrome. Treatment corresponds to drug discontinuation. We report a rare case of sub-acute cutaneous lupus erythematosus with leukocytoclastic vasculitis induced by adalimumab in a 42-year-old patient. |
| first_indexed | 2024-12-20T09:26:45Z |
| format | Article |
| id | doaj.art-37169c4d4612449b9ed8181c1caa45e9 |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-12-20T09:26:45Z |
| publishDate | 2015-06-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-37169c4d4612449b9ed8181c1caa45e92022-12-21T19:45:10ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962015-06-01903 suppl 112112410.1590/abd1806-4841.20153834Drug-induced lupus with leukocytoclastic vasculitis: a rare expression associated with adalimumabCarolina Forte AmaranteLivia Mendes Sabia AcedoFátima Maria de Oliveira RabayBenedito do Espírito Santo CamposMárcia Lanzoni de Alvarenga LiraSamuel Henrique MandelbaumAbstractTNF alpha antagonist-induced lupus-like syndrome is a rare condition which predominantly affects women (4:1). The average age of onset is 46-51 years. It occurs after exposure to TNF alpha antagonist and disappears after discontinuation of such agents. The pathogenic mechanism for development of the TNF alpha antagonist-induced lupus-like syndrome is not fully defined. It is believed that the medication induces apoptosis, leading to an accumulation of nucleosomal antigens of apoptotic cells. This would cause autoantibodies to be produced by susceptible individuals. The most common cutaneous manifestations include maculopapular exanthem, malar rash, alopecia, photosensitivity and, more rarely, vasculitis. Extracutaneous manifestations include: fever, weight loss, arthritis or arthralgia, myositis and hematological abnormalities. Antinuclear antibody may be positive in 80% of cases and anti-histone antibody is considered a disease marker for TNF alpha antagonist-induced lupus-like syndrome. Treatment corresponds to drug discontinuation. We report a rare case of sub-acute cutaneous lupus erythematosus with leukocytoclastic vasculitis induced by adalimumab in a 42-year-old patient.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000700121&tlng=enExposure to biological agentsTumor necrosis factor-alphaVasculitis, leukocytoclastic, cutaneous |
| spellingShingle | Carolina Forte Amarante Livia Mendes Sabia Acedo Fátima Maria de Oliveira Rabay Benedito do Espírito Santo Campos Márcia Lanzoni de Alvarenga Lira Samuel Henrique Mandelbaum Drug-induced lupus with leukocytoclastic vasculitis: a rare expression associated with adalimumab Anais Brasileiros de Dermatologia Exposure to biological agents Tumor necrosis factor-alpha Vasculitis, leukocytoclastic, cutaneous |
| title | Drug-induced lupus with leukocytoclastic vasculitis: a rare expression associated with adalimumab |
| title_full | Drug-induced lupus with leukocytoclastic vasculitis: a rare expression associated with adalimumab |
| title_fullStr | Drug-induced lupus with leukocytoclastic vasculitis: a rare expression associated with adalimumab |
| title_full_unstemmed | Drug-induced lupus with leukocytoclastic vasculitis: a rare expression associated with adalimumab |
| title_short | Drug-induced lupus with leukocytoclastic vasculitis: a rare expression associated with adalimumab |
| title_sort | drug induced lupus with leukocytoclastic vasculitis a rare expression associated with adalimumab |
| topic | Exposure to biological agents Tumor necrosis factor-alpha Vasculitis, leukocytoclastic, cutaneous |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000700121&tlng=en |
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