HDAC7: a promising target in cancer
Histones have a vital function as components of nucleosomes, which serve as the fundamental building blocks of chromatin. Histone deacetylases (HDACs), which target histones, suppress gene transcription by compacting chromatin. This implies that HDACs have a strong connection to the suppression of g...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1327933/full |
| _version_ | 1797292393157885952 |
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| author | Cui Liu Dan Zheng Xuan Pu Sijun Li |
| author_facet | Cui Liu Dan Zheng Xuan Pu Sijun Li |
| author_sort | Cui Liu |
| collection | DOAJ |
| description | Histones have a vital function as components of nucleosomes, which serve as the fundamental building blocks of chromatin. Histone deacetylases (HDACs), which target histones, suppress gene transcription by compacting chromatin. This implies that HDACs have a strong connection to the suppression of gene transcription. Histone deacetylase 7 (HDAC7), a member of the histone deacetylase family, may participate in multiple cellular pathophysiological processes and activate relevant signaling pathways to facilitate the progression of different tumors by exerting deacetylation. In recent years, HDAC7 has been increasingly studied in the pathogenesis of tumors. Studies that are pertinent have indicated that it has a significant impact on the growth and metastasis of tumors, the formation of the vascular microenvironment, and the emergence of resistance to drugs. Therefore, HDAC7 could potentially function as a potent predictor for tumor prognosis and a promising target for mitigating drug resistance in tumors. This review primarily concentrates on elucidating the structure and function of HDAC7, its involvement in the development of various tumors, and its interplay with relevant signaling pathways. Meanwhile, we briefly discuss the research direction and prospect of HDAC7. |
| first_indexed | 2024-03-07T19:52:02Z |
| format | Article |
| id | doaj.art-37169dfacb4e435b83584ac3f8fa193c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-07T19:52:02Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-37169dfacb4e435b83584ac3f8fa193c2024-02-28T15:25:30ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-02-011410.3389/fonc.2024.13279331327933HDAC7: a promising target in cancerCui LiuDan ZhengXuan PuSijun LiHistones have a vital function as components of nucleosomes, which serve as the fundamental building blocks of chromatin. Histone deacetylases (HDACs), which target histones, suppress gene transcription by compacting chromatin. This implies that HDACs have a strong connection to the suppression of gene transcription. Histone deacetylase 7 (HDAC7), a member of the histone deacetylase family, may participate in multiple cellular pathophysiological processes and activate relevant signaling pathways to facilitate the progression of different tumors by exerting deacetylation. In recent years, HDAC7 has been increasingly studied in the pathogenesis of tumors. Studies that are pertinent have indicated that it has a significant impact on the growth and metastasis of tumors, the formation of the vascular microenvironment, and the emergence of resistance to drugs. Therefore, HDAC7 could potentially function as a potent predictor for tumor prognosis and a promising target for mitigating drug resistance in tumors. This review primarily concentrates on elucidating the structure and function of HDAC7, its involvement in the development of various tumors, and its interplay with relevant signaling pathways. Meanwhile, we briefly discuss the research direction and prospect of HDAC7.https://www.frontiersin.org/articles/10.3389/fonc.2024.1327933/fullHDAC7cancersignaling pathwaymolecular mechanisminhibitors |
| spellingShingle | Cui Liu Dan Zheng Xuan Pu Sijun Li HDAC7: a promising target in cancer Frontiers in Oncology HDAC7 cancer signaling pathway molecular mechanism inhibitors |
| title | HDAC7: a promising target in cancer |
| title_full | HDAC7: a promising target in cancer |
| title_fullStr | HDAC7: a promising target in cancer |
| title_full_unstemmed | HDAC7: a promising target in cancer |
| title_short | HDAC7: a promising target in cancer |
| title_sort | hdac7 a promising target in cancer |
| topic | HDAC7 cancer signaling pathway molecular mechanism inhibitors |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1327933/full |
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