Comparison of intravenous lignocaine versus combination of lignocaine with diltiazem on attenuation of haemodynamic responses to tracheal extubation in patients undergoing abdominal surgeries under general anaesthesia: A randomized double blind interventi
Background: Tracheal intubation is frequently associated with cardiovascular stress response characterized by hypertension, tachycardia and increased serum concentration of catecholamines and similar phenomenon is also seen during extubation. During Endotracheal extubation increase in sympathoadrene...
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| Format: | Article |
| Language: | English |
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Creative Pharma Assent
2022-12-01
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| Series: | Journal of Applied Pharmaceutical Research |
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| Online Access: | https://japtronline.com/index.php/joapr/article/view/297 |
| _version_ | 1797842694564741120 |
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| author | Kanchan Chauhan Vivek Gupta Sunil Chauhan Manoj Soni |
| author_facet | Kanchan Chauhan Vivek Gupta Sunil Chauhan Manoj Soni |
| author_sort | Kanchan Chauhan |
| collection | DOAJ |
| description | Background: Tracheal intubation is frequently associated with cardiovascular stress response characterized by hypertension, tachycardia and increased serum concentration of catecholamines and similar phenomenon is also seen during extubation. During Endotracheal extubation increase in sympathoadrenergic activity is caused by epipharyngeal and laryngopharyngeal stimulation. Objective: The aim and objectives of this study are to compare the effect of combination of intravenous (i.v.) diltiazem 0.1 mg/kg and i.v lignocaine 1.0 mg/kg vs intravenous lignocaine alone to attenuate haemodynamic extubation responses and airway reflexes during extubation. Material and method: This study was undertaken with 72 patients belonging to the age group 20–60 years with physical status ASA Classes I and II of either sex. Group A received injection diltiazem 0.1 mg/kg and lignocaine 1 mg/kg. Group B received injection lignocaine 1 mg/kg with normal saline. In this study, the drug dosage was fixed based on the previous studies. Result: The baseline values of heart rate,systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were statistically comparable between the two groups. The heart rate, SBP, DBP, and MAP was significantly high in group A (lignocaine) as compared to group B (diltiazem with lignocaine) at extubation and till 1 min, 3 min, 5 min, and 10 min post extubation (pvalue<0.05). Conclusion: Combined diltiazem and lignocaine provides more effective prophylaxis than lignocaine alone for attenuating the cardiovascular responses to tracheal extubation |
| first_indexed | 2024-04-09T16:53:17Z |
| format | Article |
| id | doaj.art-3716bc28f85d4664b14df4202f753437 |
| institution | Directory Open Access Journal |
| issn | 2348-0335 |
| language | English |
| last_indexed | 2024-04-09T16:53:17Z |
| publishDate | 2022-12-01 |
| publisher | Creative Pharma Assent |
| record_format | Article |
| series | Journal of Applied Pharmaceutical Research |
| spelling | doaj.art-3716bc28f85d4664b14df4202f7534372023-04-21T09:28:16ZengCreative Pharma AssentJournal of Applied Pharmaceutical Research2348-03352022-12-01104253310.18231/j.joapr.2022.10.4.25.33298Comparison of intravenous lignocaine versus combination of lignocaine with diltiazem on attenuation of haemodynamic responses to tracheal extubation in patients undergoing abdominal surgeries under general anaesthesia: A randomized double blind interventiKanchan Chauhan0Vivek Gupta1https://orcid.org/0000-0003-3203-2755Sunil Chauhan2https://orcid.org/0000-0002-0158-7427Manoj Soni3https://orcid.org/0000-0002-6011-4849Department of Anaesthesiology and Critical Care, S.M.S. Medical College and Attached Group of Hospitals, Sawai Mansingh road, Jaipur, 302004Department of Anaesthesiology and Critical Care, S.M.S. Medical College and Attached Group of Hospitals, Sawai Mansingh road, Jaipur, 302004Department of Anaesthesiology and Critical Care, S.M.S. Medical College and Attached Group of Hospitals, Sawai Mansingh road, Jaipur, 302004Department of Anaesthesiology and Critical Care, S.M.S. Medical College and Attached Group of Hospitals, Sawai Mansingh road, Jaipur, 302004Background: Tracheal intubation is frequently associated with cardiovascular stress response characterized by hypertension, tachycardia and increased serum concentration of catecholamines and similar phenomenon is also seen during extubation. During Endotracheal extubation increase in sympathoadrenergic activity is caused by epipharyngeal and laryngopharyngeal stimulation. Objective: The aim and objectives of this study are to compare the effect of combination of intravenous (i.v.) diltiazem 0.1 mg/kg and i.v lignocaine 1.0 mg/kg vs intravenous lignocaine alone to attenuate haemodynamic extubation responses and airway reflexes during extubation. Material and method: This study was undertaken with 72 patients belonging to the age group 20–60 years with physical status ASA Classes I and II of either sex. Group A received injection diltiazem 0.1 mg/kg and lignocaine 1 mg/kg. Group B received injection lignocaine 1 mg/kg with normal saline. In this study, the drug dosage was fixed based on the previous studies. Result: The baseline values of heart rate,systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were statistically comparable between the two groups. The heart rate, SBP, DBP, and MAP was significantly high in group A (lignocaine) as compared to group B (diltiazem with lignocaine) at extubation and till 1 min, 3 min, 5 min, and 10 min post extubation (pvalue<0.05). Conclusion: Combined diltiazem and lignocaine provides more effective prophylaxis than lignocaine alone for attenuating the cardiovascular responses to tracheal extubationhttps://japtronline.com/index.php/joapr/article/view/297lignocainediltiazemattenuationhemodynamic responsetracheal extubation |
| spellingShingle | Kanchan Chauhan Vivek Gupta Sunil Chauhan Manoj Soni Comparison of intravenous lignocaine versus combination of lignocaine with diltiazem on attenuation of haemodynamic responses to tracheal extubation in patients undergoing abdominal surgeries under general anaesthesia: A randomized double blind interventi Journal of Applied Pharmaceutical Research lignocaine diltiazem attenuation hemodynamic response tracheal extubation |
| title | Comparison of intravenous lignocaine versus combination of lignocaine with diltiazem on attenuation of haemodynamic responses to tracheal extubation in patients undergoing abdominal surgeries under general anaesthesia: A randomized double blind interventi |
| title_full | Comparison of intravenous lignocaine versus combination of lignocaine with diltiazem on attenuation of haemodynamic responses to tracheal extubation in patients undergoing abdominal surgeries under general anaesthesia: A randomized double blind interventi |
| title_fullStr | Comparison of intravenous lignocaine versus combination of lignocaine with diltiazem on attenuation of haemodynamic responses to tracheal extubation in patients undergoing abdominal surgeries under general anaesthesia: A randomized double blind interventi |
| title_full_unstemmed | Comparison of intravenous lignocaine versus combination of lignocaine with diltiazem on attenuation of haemodynamic responses to tracheal extubation in patients undergoing abdominal surgeries under general anaesthesia: A randomized double blind interventi |
| title_short | Comparison of intravenous lignocaine versus combination of lignocaine with diltiazem on attenuation of haemodynamic responses to tracheal extubation in patients undergoing abdominal surgeries under general anaesthesia: A randomized double blind interventi |
| title_sort | comparison of intravenous lignocaine versus combination of lignocaine with diltiazem on attenuation of haemodynamic responses to tracheal extubation in patients undergoing abdominal surgeries under general anaesthesia a randomized double blind interventi |
| topic | lignocaine diltiazem attenuation hemodynamic response tracheal extubation |
| url | https://japtronline.com/index.php/joapr/article/view/297 |
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