Quantifying Physiological Biomarkers of a Microwave Brain Stimulation Device
Physiological signals are immediate and sensitive to neural and cardiovascular change resulting from brain stimulation, and are considered as a quantifying tool with which to evaluate the association between brain stimulation and cognitive performance. Brain stimulation outside a highly equipped, cl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/21/5/1896 |
| _version_ | 1797542173082648576 |
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| author | Iqram Hussain Seo Young Chang Ho Kim Ho Chee Meng Benjamin Se Jin Park |
| author_facet | Iqram Hussain Seo Young Chang Ho Kim Ho Chee Meng Benjamin Se Jin Park |
| author_sort | Iqram Hussain |
| collection | DOAJ |
| description | Physiological signals are immediate and sensitive to neural and cardiovascular change resulting from brain stimulation, and are considered as a quantifying tool with which to evaluate the association between brain stimulation and cognitive performance. Brain stimulation outside a highly equipped, clinical setting requires the use of a low-cost, ambulatory miniature system. The purpose of this double-blind, randomized, sham-controlled study is to quantify the physiological biomarkers of the neural and cardiovascular systems induced by a microwave brain stimulation (MBS) device. We investigated the effect of an active MBS and a sham device on the cardiovascular and neurological responses of ten volunteers (mean age 26.33 years, 70% male). Electroencephalography (EEG) and electrocardiography (ECG) were recorded in the initial resting-state, intermediate state, and the final state at half-hour intervals using a portable sensing device. During the experiment, the participants were engaged in a cognitive workload. In the active MBS group, the power of high-alpha, high-beta, and low-beta bands in the EEG increased, and the power of low-alpha and theta waves decreased, relative to the sham group. RR Interval and QRS interval showed a significant association with MBS stimulation. Heart rate variability features showed no significant difference between the two groups. A wearable MBS modality may be feasible for use in biomedical research; the MBS can modulate the neurological and cardiovascular responses to cognitive workload. |
| first_indexed | 2024-03-10T13:25:54Z |
| format | Article |
| id | doaj.art-371915f2bad4428a815c97a1c73439cf |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-10T13:25:54Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-371915f2bad4428a815c97a1c73439cf2023-11-21T09:36:58ZengMDPI AGSensors1424-82202021-03-01215189610.3390/s21051896Quantifying Physiological Biomarkers of a Microwave Brain Stimulation DeviceIqram Hussain0Seo Young1Chang Ho Kim2Ho Chee Meng Benjamin3Se Jin Park4Center for Medical Convergence Metrology, Korea Research Institute of Standards and Science, Daejeon 34113, KoreaCenter for Medical Convergence Metrology, Korea Research Institute of Standards and Science, Daejeon 34113, KoreaUNITECH CO., Ltd., Seoul 08289, KoreaAI Research Group, Sewon Intelligence, Ltd., Seoul 04512, KoreaCenter for Medical Convergence Metrology, Korea Research Institute of Standards and Science, Daejeon 34113, KoreaPhysiological signals are immediate and sensitive to neural and cardiovascular change resulting from brain stimulation, and are considered as a quantifying tool with which to evaluate the association between brain stimulation and cognitive performance. Brain stimulation outside a highly equipped, clinical setting requires the use of a low-cost, ambulatory miniature system. The purpose of this double-blind, randomized, sham-controlled study is to quantify the physiological biomarkers of the neural and cardiovascular systems induced by a microwave brain stimulation (MBS) device. We investigated the effect of an active MBS and a sham device on the cardiovascular and neurological responses of ten volunteers (mean age 26.33 years, 70% male). Electroencephalography (EEG) and electrocardiography (ECG) were recorded in the initial resting-state, intermediate state, and the final state at half-hour intervals using a portable sensing device. During the experiment, the participants were engaged in a cognitive workload. In the active MBS group, the power of high-alpha, high-beta, and low-beta bands in the EEG increased, and the power of low-alpha and theta waves decreased, relative to the sham group. RR Interval and QRS interval showed a significant association with MBS stimulation. Heart rate variability features showed no significant difference between the two groups. A wearable MBS modality may be feasible for use in biomedical research; the MBS can modulate the neurological and cardiovascular responses to cognitive workload.https://www.mdpi.com/1424-8220/21/5/1896microwave brain stimulationphysiological biomarkercognitive workloadwearable bioelectronic medicine |
| spellingShingle | Iqram Hussain Seo Young Chang Ho Kim Ho Chee Meng Benjamin Se Jin Park Quantifying Physiological Biomarkers of a Microwave Brain Stimulation Device Sensors microwave brain stimulation physiological biomarker cognitive workload wearable bioelectronic medicine |
| title | Quantifying Physiological Biomarkers of a Microwave Brain Stimulation Device |
| title_full | Quantifying Physiological Biomarkers of a Microwave Brain Stimulation Device |
| title_fullStr | Quantifying Physiological Biomarkers of a Microwave Brain Stimulation Device |
| title_full_unstemmed | Quantifying Physiological Biomarkers of a Microwave Brain Stimulation Device |
| title_short | Quantifying Physiological Biomarkers of a Microwave Brain Stimulation Device |
| title_sort | quantifying physiological biomarkers of a microwave brain stimulation device |
| topic | microwave brain stimulation physiological biomarker cognitive workload wearable bioelectronic medicine |
| url | https://www.mdpi.com/1424-8220/21/5/1896 |
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