A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption
Analytic treatment interruptions (ATIs) are currently the standard for assessing the impact of experimental interventions aimed at inducing sustained antiretroviral therapy (ART)-free remission in trials related to HIV cure. ATIs are associated with substantial risk to both study participants and th...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-01-01
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| Series: | Journal of Virus Eradication |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2055664020300091 |
| _version_ | 1818717483677253632 |
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| author | Michael J. Peluso Lynda Dee Danielle Campbell Jeff Taylor Rebecca Hoh Rachel L. Rutishauser John Sauceda Steven G. Deeks Karine Dubé |
| author_facet | Michael J. Peluso Lynda Dee Danielle Campbell Jeff Taylor Rebecca Hoh Rachel L. Rutishauser John Sauceda Steven G. Deeks Karine Dubé |
| author_sort | Michael J. Peluso |
| collection | DOAJ |
| description | Analytic treatment interruptions (ATIs) are currently the standard for assessing the impact of experimental interventions aimed at inducing sustained antiretroviral therapy (ART)-free remission in trials related to HIV cure. ATIs are associated with substantial risk to both study participants and their sexual partner(s). Two documented HIV transmissions occurring in the context of ATIs have been recently reported, but recommendations for mitigating the risk of such events during ATIs are limited. We outline a practical approach to risk mitigation during ATI studies and describe strategies we are utilising in an upcoming clinical trial that may be applicable to other centres. |
| first_indexed | 2024-12-17T19:35:52Z |
| format | Article |
| id | doaj.art-371a0d05de1f426b80f54cf78b2197fc |
| institution | Directory Open Access Journal |
| issn | 2055-6640 |
| language | English |
| last_indexed | 2024-12-17T19:35:52Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Virus Eradication |
| spelling | doaj.art-371a0d05de1f426b80f54cf78b2197fc2022-12-21T21:35:09ZengElsevierJournal of Virus Eradication2055-66402020-01-01613437A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruptionMichael J. Peluso0Lynda Dee1Danielle Campbell2Jeff Taylor3Rebecca Hoh4Rachel L. Rutishauser5John Sauceda6Steven G. Deeks7Karine Dubé8Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA; Corresponding author: Michael J Peluso, 995 Potrero Ave, Building 80, San Francisco, CA 94110 USAAIDS Action Baltimore, Baltimore, MD, USA; amfAR Institute for HIV Cure Research Community Advisory Board, USA; Delaney AIDS Research Enterprise Community Advisory Board, USA; Martin Delaney Collaboratory Community Advisory Board, USAamfAR Institute for HIV Cure Research Community Advisory Board, USA; Delaney AIDS Research Enterprise Community Advisory Board, USA; Martin Delaney Collaboratory Community Advisory Board, USA; Charles R Drew University of Medicine and Science, Los Angeles, CA, USAamfAR Institute for HIV Cure Research Community Advisory Board, USA; Martin Delaney Collaboratory Community Advisory Board, USA; University of California, San Diego Antiviral Research Center Community Advisory Board, San Diego, CA, USA; HIV+Aging Research Project, Palm Springs, CA, USADivision of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USADivision of Experimental Medicine, UCSF, San Francisco, CA, USACenter for AIDS Prevention Studies, UCSF, San Francisco, CA, USADivision of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USAUNC Gillings School of Global Public Health, Chapel Hill, NC, USAAnalytic treatment interruptions (ATIs) are currently the standard for assessing the impact of experimental interventions aimed at inducing sustained antiretroviral therapy (ART)-free remission in trials related to HIV cure. ATIs are associated with substantial risk to both study participants and their sexual partner(s). Two documented HIV transmissions occurring in the context of ATIs have been recently reported, but recommendations for mitigating the risk of such events during ATIs are limited. We outline a practical approach to risk mitigation during ATI studies and describe strategies we are utilising in an upcoming clinical trial that may be applicable to other centres.http://www.sciencedirect.com/science/article/pii/S2055664020300091HIVHIV cure researchHIV remission researchanalytical treatment interruption |
| spellingShingle | Michael J. Peluso Lynda Dee Danielle Campbell Jeff Taylor Rebecca Hoh Rachel L. Rutishauser John Sauceda Steven G. Deeks Karine Dubé A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption Journal of Virus Eradication HIV HIV cure research HIV remission research analytical treatment interruption |
| title | A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption |
| title_full | A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption |
| title_fullStr | A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption |
| title_full_unstemmed | A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption |
| title_short | A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption |
| title_sort | collaborative multidisciplinary approach to hiv transmission risk mitigation during analytic treatment interruption |
| topic | HIV HIV cure research HIV remission research analytical treatment interruption |
| url | http://www.sciencedirect.com/science/article/pii/S2055664020300091 |
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