CPSF6 regulates alternative polyadenylation and proliferation of cancer cells through phase separation

CPSF6 regulates alternative polyadenylation and proliferation of cancer cells through phase separation

Summary: Cancer cells usually exhibit shortened 3′ untranslated regions (UTRs) due to alternative polyadenylation (APA) to promote cell proliferation and migration. Upregulated CPSF6 leads to a systematic prolongation of 3′ UTRs, but CPSF6 expression in tumors is typically higher than that in health...

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Bibliographic Details
Main Authors: Susu Liu, Runze Wu, Liutao Chen, Ke Deng, Xin Ou, Xin Lu, Mengxia Li, Chao Liu, Shangwu Chen, Yonggui Fu, Anlong Xu
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Cell Reports
Subjects:
CP:Cancer
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723012093

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