TRIM Proteins and Their Roles in the Influenza Virus Life Cycle
The ubiquitin-proteasome system (UPS) has been recognized for regulating fundamental cellular processes, followed by induction of proteasomal degradation of target proteins, and triggers multiple signaling pathways that are crucial for numerous aspects of cellular physiology. Especially tripartite m...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/8/9/1424 |
| _version_ | 1797553505107443712 |
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| author | Hye-Ra Lee Myoung Kyu Lee Chan Woo Kim Meehyein Kim |
| author_facet | Hye-Ra Lee Myoung Kyu Lee Chan Woo Kim Meehyein Kim |
| author_sort | Hye-Ra Lee |
| collection | DOAJ |
| description | The ubiquitin-proteasome system (UPS) has been recognized for regulating fundamental cellular processes, followed by induction of proteasomal degradation of target proteins, and triggers multiple signaling pathways that are crucial for numerous aspects of cellular physiology. Especially tripartite motif (TRIM) proteins, well-known E3 ubiquitin ligases, emerge as having critical roles in several antiviral signaling pathways against varying viral infections. Here we highlight recent advances in the study of antiviral roles of TRIM proteins toward influenza virus infection in terms of the modulation of pathogen recognition receptor (PRR)-mediated innate immune sensing, direct obstruction of influenza viral propagation, and participation in virus-induced autophagy. |
| first_indexed | 2024-03-10T16:17:23Z |
| format | Article |
| id | doaj.art-371c99e4a033402195a4da61049c0843 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T16:17:23Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-371c99e4a033402195a4da61049c08432023-11-20T13:56:29ZengMDPI AGMicroorganisms2076-26072020-09-0189142410.3390/microorganisms8091424TRIM Proteins and Their Roles in the Influenza Virus Life CycleHye-Ra Lee0Myoung Kyu Lee1Chan Woo Kim2Meehyein Kim3Department of Biotechnology and Bioinformatics, College of Science and Technology, Korea University, 2511 Sejong-ro, Sejong 30019, KoreaInfectious Diseases Therapeutics Research Center, Korea Research Institute of Chemical Technology, 141 Gajeongro, Yuseong, Daejeon 34114, KoreaDepartment of Biotechnology and Bioinformatics, College of Science and Technology, Korea University, 2511 Sejong-ro, Sejong 30019, KoreaInfectious Diseases Therapeutics Research Center, Korea Research Institute of Chemical Technology, 141 Gajeongro, Yuseong, Daejeon 34114, KoreaThe ubiquitin-proteasome system (UPS) has been recognized for regulating fundamental cellular processes, followed by induction of proteasomal degradation of target proteins, and triggers multiple signaling pathways that are crucial for numerous aspects of cellular physiology. Especially tripartite motif (TRIM) proteins, well-known E3 ubiquitin ligases, emerge as having critical roles in several antiviral signaling pathways against varying viral infections. Here we highlight recent advances in the study of antiviral roles of TRIM proteins toward influenza virus infection in terms of the modulation of pathogen recognition receptor (PRR)-mediated innate immune sensing, direct obstruction of influenza viral propagation, and participation in virus-induced autophagy.https://www.mdpi.com/2076-2607/8/9/1424influenza virusubiquitinationantiviral immunityTRIM family |
| spellingShingle | Hye-Ra Lee Myoung Kyu Lee Chan Woo Kim Meehyein Kim TRIM Proteins and Their Roles in the Influenza Virus Life Cycle Microorganisms influenza virus ubiquitination antiviral immunity TRIM family |
| title | TRIM Proteins and Their Roles in the Influenza Virus Life Cycle |
| title_full | TRIM Proteins and Their Roles in the Influenza Virus Life Cycle |
| title_fullStr | TRIM Proteins and Their Roles in the Influenza Virus Life Cycle |
| title_full_unstemmed | TRIM Proteins and Their Roles in the Influenza Virus Life Cycle |
| title_short | TRIM Proteins and Their Roles in the Influenza Virus Life Cycle |
| title_sort | trim proteins and their roles in the influenza virus life cycle |
| topic | influenza virus ubiquitination antiviral immunity TRIM family |
| url | https://www.mdpi.com/2076-2607/8/9/1424 |
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