PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4

PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4

Summary: The ε4 allele of apolipoprotein E (APOE4) is a genetic risk factor for many diseases, including late-onset Alzheimer’s disease (AD). We investigate the cellular consequences of APOE4 in human iPSC-derived astrocytes, observing an endocytic defect in APOE4 astrocytes compared with their isog...

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Bibliographic Details
Main Authors: Priyanka Narayan, Grzegorz Sienski, Julia M. Bonner, Yuan-Ta Lin, Jinsoo Seo, Valeriya Baru, Aftabul Haque, Blerta Milo, Leyla A. Akay, Agnese Graziosi, Yelena Freyzon, Dirk Landgraf, William R. Hesse, Julie Valastyan, M. Inmaculada Barrasa, Li-Huei Tsai, Susan Lindquist
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
apolipoprotein E
Alzheimer's disease
genetic risk factors
PICALM
endocytosis
trafficking
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312134

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