Risk Factors for Development of Chronic Kidney Disease in Cats
Background Identification of risk factors for development of chronic kidney disease (CKD) in cats may aid in its earlier detection. Hypothesis/objectives Evaluation of clinical and questionnaire data will identify risk factors for development of azotemic CKD in cats. Animals One hundred and forty‐ei...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-03-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.13917 |
| _version_ | 1818740648455438336 |
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| author | N.C. Finch H.M. Syme J. Elliott |
| author_facet | N.C. Finch H.M. Syme J. Elliott |
| author_sort | N.C. Finch |
| collection | DOAJ |
| description | Background Identification of risk factors for development of chronic kidney disease (CKD) in cats may aid in its earlier detection. Hypothesis/objectives Evaluation of clinical and questionnaire data will identify risk factors for development of azotemic CKD in cats. Animals One hundred and forty‐eight client‐owned geriatric (>9 years) cats. Methods Cats were recruited into the study and followed longitudinally for a variable time. Owners were asked to complete a questionnaire regarding their pet at enrollment. Additional data regarding dental disease were obtained when available by development of a dental categorization system. Variables were explored in univariable and multivariable Cox regression models. Results In the final multivariable Cox regression model, annual/frequent vaccination (P value, .003; hazard ratio, 5.68; 95% confidence interval, 1.83–17.64), moderate dental disease (P value, .008; hazard ratio, 13.83; 95% confidence interval, 2.01–94.99), and severe dental disease (P value, .001; hazard ratio, 35.35; 95% confidence interval, 4.31–289.73) predicted development of azotemic CKD. Conclusion Our study suggests independent associations between both vaccination frequency and severity of dental disease and development of CKD. Further studies to explore the pathophysiological mechanism of renal injury for these risk factors are warranted. |
| first_indexed | 2024-12-18T01:44:04Z |
| format | Article |
| id | doaj.art-371d7f04621b44c080a798ec94787730 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-12-18T01:44:04Z |
| publishDate | 2016-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-371d7f04621b44c080a798ec947877302022-12-21T21:25:14ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762016-03-0130260261010.1111/jvim.13917Risk Factors for Development of Chronic Kidney Disease in CatsN.C. Finch0H.M. Syme1J. Elliott2Bristol Renal School of Clinical Sciences University of Bristol Bristol UKDepartment of Clinical Science and Services Royal Veterinary College Hatfield Herts UKDepartment of Comparative Biomedical Sciences Royal Veterinary College London UKBackground Identification of risk factors for development of chronic kidney disease (CKD) in cats may aid in its earlier detection. Hypothesis/objectives Evaluation of clinical and questionnaire data will identify risk factors for development of azotemic CKD in cats. Animals One hundred and forty‐eight client‐owned geriatric (>9 years) cats. Methods Cats were recruited into the study and followed longitudinally for a variable time. Owners were asked to complete a questionnaire regarding their pet at enrollment. Additional data regarding dental disease were obtained when available by development of a dental categorization system. Variables were explored in univariable and multivariable Cox regression models. Results In the final multivariable Cox regression model, annual/frequent vaccination (P value, .003; hazard ratio, 5.68; 95% confidence interval, 1.83–17.64), moderate dental disease (P value, .008; hazard ratio, 13.83; 95% confidence interval, 2.01–94.99), and severe dental disease (P value, .001; hazard ratio, 35.35; 95% confidence interval, 4.31–289.73) predicted development of azotemic CKD. Conclusion Our study suggests independent associations between both vaccination frequency and severity of dental disease and development of CKD. Further studies to explore the pathophysiological mechanism of renal injury for these risk factors are warranted.https://doi.org/10.1111/jvim.13917FelinePredictorsRenal |
| spellingShingle | N.C. Finch H.M. Syme J. Elliott Risk Factors for Development of Chronic Kidney Disease in Cats Journal of Veterinary Internal Medicine Feline Predictors Renal |
| title | Risk Factors for Development of Chronic Kidney Disease in Cats |
| title_full | Risk Factors for Development of Chronic Kidney Disease in Cats |
| title_fullStr | Risk Factors for Development of Chronic Kidney Disease in Cats |
| title_full_unstemmed | Risk Factors for Development of Chronic Kidney Disease in Cats |
| title_short | Risk Factors for Development of Chronic Kidney Disease in Cats |
| title_sort | risk factors for development of chronic kidney disease in cats |
| topic | Feline Predictors Renal |
| url | https://doi.org/10.1111/jvim.13917 |
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