Morpho-electric diversity of human hippocampal CA1 pyramidal neurons
Summary: Hippocampal pyramidal neuron activity underlies episodic memory and spatial navigation. Although extensively studied in rodents, extremely little is known about human hippocampal pyramidal neurons, even though the human hippocampus underwent strong evolutionary reorganization and shows lowe...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724004285 |
| _version_ | 1827287370661101568 |
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| author | Eline J. Mertens Yoni Leibner Jean Pie Anna A. Galakhova Femke Waleboer Julia Meijer Tim S. Heistek René Wilbers Djai Heyer Natalia A. Goriounova Sander Idema Matthijs B. Verhoog Brian E. Kalmbach Brian R. Lee Ryder P. Gwinn Ed S. Lein Eleonora Aronica Jonathan Ting Huibert D. Mansvelder Idan Segev Christiaan P.J. de Kock |
| author_facet | Eline J. Mertens Yoni Leibner Jean Pie Anna A. Galakhova Femke Waleboer Julia Meijer Tim S. Heistek René Wilbers Djai Heyer Natalia A. Goriounova Sander Idema Matthijs B. Verhoog Brian E. Kalmbach Brian R. Lee Ryder P. Gwinn Ed S. Lein Eleonora Aronica Jonathan Ting Huibert D. Mansvelder Idan Segev Christiaan P.J. de Kock |
| author_sort | Eline J. Mertens |
| collection | DOAJ |
| description | Summary: Hippocampal pyramidal neuron activity underlies episodic memory and spatial navigation. Although extensively studied in rodents, extremely little is known about human hippocampal pyramidal neurons, even though the human hippocampus underwent strong evolutionary reorganization and shows lower theta rhythm frequencies. To test whether biophysical properties of human Cornu Amonis subfield 1 (CA1) pyramidal neurons can explain observed rhythms, we map the morpho-electric properties of individual CA1 pyramidal neurons in human, non-pathological hippocampal slices from neurosurgery. Human CA1 pyramidal neurons have much larger dendritic trees than mouse CA1 pyramidal neurons, have a large number of oblique dendrites, and resonate at 2.9 Hz, optimally tuned to human theta frequencies. Morphological and biophysical properties suggest cellular diversity along a multidimensional gradient rather than discrete clustering. Across the population, dendritic architecture and a large number of oblique dendrites consistently boost memory capacity in human CA1 pyramidal neurons by an order of magnitude compared to mouse CA1 pyramidal neurons. |
| first_indexed | 2024-04-24T10:57:13Z |
| format | Article |
| id | doaj.art-371ff7956af64d3bbda89f13ea9ec965 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-24T10:57:13Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-371ff7956af64d3bbda89f13ea9ec9652024-04-12T04:45:07ZengElsevierCell Reports2211-12472024-04-01434114100Morpho-electric diversity of human hippocampal CA1 pyramidal neuronsEline J. Mertens0Yoni Leibner1Jean Pie2Anna A. Galakhova3Femke Waleboer4Julia Meijer5Tim S. Heistek6René Wilbers7Djai Heyer8Natalia A. Goriounova9Sander Idema10Matthijs B. Verhoog11Brian E. Kalmbach12Brian R. Lee13Ryder P. Gwinn14Ed S. Lein15Eleonora Aronica16Jonathan Ting17Huibert D. Mansvelder18Idan Segev19Christiaan P.J. de Kock20Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the NetherlandsThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, IsraelCenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the NetherlandsCenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the NetherlandsCenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the NetherlandsCenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the NetherlandsCenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the NetherlandsCenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the NetherlandsCenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the NetherlandsCenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the NetherlandsAmsterdam UMC, location VUmc, Amsterdam 1081 HV, the NetherlandsCenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the NetherlandsAllen Institute for Brain Science, Seattle, WA 98109, USAAllen Institute for Brain Science, Seattle, WA 98109, USAEpilepsy Surgery and Functional Neurosurgery, Swedish Neuroscience Institute, Seattle, WA 98122, USAAllen Institute for Brain Science, Seattle, WA 98109, USADepartment of (Neuro)Pathology, Amsterdam Neuroscience, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, the NetherlandsAllen Institute for Brain Science, Seattle, WA 98109, USACenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the Netherlands; Corresponding authorThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel; Corresponding authorCenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the Netherlands; Corresponding authorSummary: Hippocampal pyramidal neuron activity underlies episodic memory and spatial navigation. Although extensively studied in rodents, extremely little is known about human hippocampal pyramidal neurons, even though the human hippocampus underwent strong evolutionary reorganization and shows lower theta rhythm frequencies. To test whether biophysical properties of human Cornu Amonis subfield 1 (CA1) pyramidal neurons can explain observed rhythms, we map the morpho-electric properties of individual CA1 pyramidal neurons in human, non-pathological hippocampal slices from neurosurgery. Human CA1 pyramidal neurons have much larger dendritic trees than mouse CA1 pyramidal neurons, have a large number of oblique dendrites, and resonate at 2.9 Hz, optimally tuned to human theta frequencies. Morphological and biophysical properties suggest cellular diversity along a multidimensional gradient rather than discrete clustering. Across the population, dendritic architecture and a large number of oblique dendrites consistently boost memory capacity in human CA1 pyramidal neurons by an order of magnitude compared to mouse CA1 pyramidal neurons.http://www.sciencedirect.com/science/article/pii/S2211124724004285CP: NeuroscienceCP: Cell biology |
| spellingShingle | Eline J. Mertens Yoni Leibner Jean Pie Anna A. Galakhova Femke Waleboer Julia Meijer Tim S. Heistek René Wilbers Djai Heyer Natalia A. Goriounova Sander Idema Matthijs B. Verhoog Brian E. Kalmbach Brian R. Lee Ryder P. Gwinn Ed S. Lein Eleonora Aronica Jonathan Ting Huibert D. Mansvelder Idan Segev Christiaan P.J. de Kock Morpho-electric diversity of human hippocampal CA1 pyramidal neurons Cell Reports CP: Neuroscience CP: Cell biology |
| title | Morpho-electric diversity of human hippocampal CA1 pyramidal neurons |
| title_full | Morpho-electric diversity of human hippocampal CA1 pyramidal neurons |
| title_fullStr | Morpho-electric diversity of human hippocampal CA1 pyramidal neurons |
| title_full_unstemmed | Morpho-electric diversity of human hippocampal CA1 pyramidal neurons |
| title_short | Morpho-electric diversity of human hippocampal CA1 pyramidal neurons |
| title_sort | morpho electric diversity of human hippocampal ca1 pyramidal neurons |
| topic | CP: Neuroscience CP: Cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724004285 |
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