Modulation of acetate utilization in Komagataella phaffii by metabolic engineering of tolerance and metabolism

Modulation of acetate utilization in Komagataella phaffii by metabolic engineering of tolerance and metabolism

Abstract Background Acetate, an economical industrial chemical, which is also the precursor of acetyl-CoA, could serve as an alternative substrate for biomanufacturing. This nontraditional substrate can be widely produced from syngas via hydrolysis or pyrolysis of the cellulosic biomass, chemical or...

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Bibliographic Details
Main Authors: Qin Xu, Chenxiao Bai, Yiqi Liu, Lili Song, Lin Tian, Yunfeng Yan, Jinfeng Zhou, Xiangshan Zhou, Yuanxing Zhang, Menghao Cai
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Biotechnology for Biofuels
Subjects:
Komagataella phaffii
Acetate utilization
Acetyl-CoA
Kinase screening
Metabolic engineering
Online Access:http://link.springer.com/article/10.1186/s13068-019-1404-0

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