Synthesis, spectroscopic characterization and pharmacological evaluation of oxazolone derivatives
A series of 4-aryl methylidene-2-phenyl/methyl-5-(4H)-oxazolone derivatives (2-7) have been synthesized using the reported method by condensation of aldehydes with N-benzoyl / N-acetyl glycine in the presence of zinc oxide as a catalyst and acetic anhydride at room temperature in ethanol. The com...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2013-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2013/0352-51391200126F.pdf |
| _version_ | 1819082297323814912 |
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| author | Fareed Ghulam Afza Nighat Versiani Ali Muhammad Fareed Nazia Mughal Rasheed Uzma Kalhoro Ali Mahboob Iqbal Lubna Lateef Mehreen |
| author_facet | Fareed Ghulam Afza Nighat Versiani Ali Muhammad Fareed Nazia Mughal Rasheed Uzma Kalhoro Ali Mahboob Iqbal Lubna Lateef Mehreen |
| author_sort | Fareed Ghulam |
| collection | DOAJ |
| description | A series of 4-aryl methylidene-2-phenyl/methyl-5-(4H)-oxazolone derivatives (2-7) have been synthesized using the reported method by condensation of aldehydes with N-benzoyl / N-acetyl glycine in the presence of zinc oxide as a catalyst and acetic anhydride at room temperature in ethanol. The compounds (2-6) are new derivatives. The structures of compounds were evaluated on the basis of 1H-NMR, 13C-NMR, EIMS, FT-IR and elemental analysis. All the compounds were screened for their antibacterial and urease inhibition activity. Antibacterial activity was tested by agar well diffusion method using Mueller Hinton Agar medium. Compound (2) showed excellent activity against S. aureus which has 16 mm (80%) inhibition and above 24 mm (70%) against S. typhi. The most active compound against E. coli was compound (6) having 20 mm (80%) inhibition followed by compound (5) having above 18 mm (70%) inhibition. Urease inhibition activity of all the compounds was determined by indophenol method. Compounds (3, 6) and (7) showed significant inhibition against Jacks bean urease. |
| first_indexed | 2024-12-21T20:14:26Z |
| format | Article |
| id | doaj.art-37213e9db79d4cdaa7c9ba31817a615a |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-12-21T20:14:26Z |
| publishDate | 2013-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-37213e9db79d4cdaa7c9ba31817a615a2022-12-21T18:51:39ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392013-01-017881127113410.2298/JSC120917126FSynthesis, spectroscopic characterization and pharmacological evaluation of oxazolone derivativesFareed GhulamAfza NighatVersiani Ali MuhammadFareed NaziaMughal Rasheed UzmaKalhoro Ali MahboobIqbal LubnaLateef MehreenA series of 4-aryl methylidene-2-phenyl/methyl-5-(4H)-oxazolone derivatives (2-7) have been synthesized using the reported method by condensation of aldehydes with N-benzoyl / N-acetyl glycine in the presence of zinc oxide as a catalyst and acetic anhydride at room temperature in ethanol. The compounds (2-6) are new derivatives. The structures of compounds were evaluated on the basis of 1H-NMR, 13C-NMR, EIMS, FT-IR and elemental analysis. All the compounds were screened for their antibacterial and urease inhibition activity. Antibacterial activity was tested by agar well diffusion method using Mueller Hinton Agar medium. Compound (2) showed excellent activity against S. aureus which has 16 mm (80%) inhibition and above 24 mm (70%) against S. typhi. The most active compound against E. coli was compound (6) having 20 mm (80%) inhibition followed by compound (5) having above 18 mm (70%) inhibition. Urease inhibition activity of all the compounds was determined by indophenol method. Compounds (3, 6) and (7) showed significant inhibition against Jacks bean urease.http://www.doiserbia.nb.rs/img/doi/0352-5139/2013/0352-51391200126F.pdfaldehydeantibacterialUrease inhibition activitiesoxazolonessynthesiszinc Oxide (ZnO) |
| spellingShingle | Fareed Ghulam Afza Nighat Versiani Ali Muhammad Fareed Nazia Mughal Rasheed Uzma Kalhoro Ali Mahboob Iqbal Lubna Lateef Mehreen Synthesis, spectroscopic characterization and pharmacological evaluation of oxazolone derivatives Journal of the Serbian Chemical Society aldehyde antibacterial Urease inhibition activities oxazolones synthesis zinc Oxide (ZnO) |
| title | Synthesis, spectroscopic characterization and pharmacological evaluation of oxazolone derivatives |
| title_full | Synthesis, spectroscopic characterization and pharmacological evaluation of oxazolone derivatives |
| title_fullStr | Synthesis, spectroscopic characterization and pharmacological evaluation of oxazolone derivatives |
| title_full_unstemmed | Synthesis, spectroscopic characterization and pharmacological evaluation of oxazolone derivatives |
| title_short | Synthesis, spectroscopic characterization and pharmacological evaluation of oxazolone derivatives |
| title_sort | synthesis spectroscopic characterization and pharmacological evaluation of oxazolone derivatives |
| topic | aldehyde antibacterial Urease inhibition activities oxazolones synthesis zinc Oxide (ZnO) |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2013/0352-51391200126F.pdf |
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