Mitochondrial dysfunction and endoplasmic reticulum stress involved in oocyte aging: an analysis using single-cell RNA-sequencing of mouse oocytes
Abstract Object To explore the mechanisms of ovarian aging, we performed overall analysis on the age-related alterations of gene expression profiles in mouse germinal vesicle (GV) stage oocytes by means of single-cell RNA-sequencing method (scRNA-seq). Methods Two age groups (5-week-old and 32-week-...
Main Authors: | Tao Zhang, Qingsong Xi, Dan Wang, Jingjing Li, Meng Wang, Dan Li, Lixia Zhu, Lei Jin |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-06-01
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Series: | Journal of Ovarian Research |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13048-019-0529-x |
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