Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women
Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. After studying 602 unvaccinated Chinese women using 16S rRNA to detect cervical-vaginal microecology, we analyzed the relationship between HPV infection and vaginal microecology including 20 HPV types. In C...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.814668/full |
| _version_ | 1811241878775922688 |
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| author | Yichan Zhang Yichan Zhang Xiaolin Xu Xiaolin Xu Liqun Yu Xingxian Shi Min Min Lijuan Xiong Jia Pan Yong Zhang Peipei Liu Guizhen Wu Guolan Gao Guolan Gao |
| author_facet | Yichan Zhang Yichan Zhang Xiaolin Xu Xiaolin Xu Liqun Yu Xingxian Shi Min Min Lijuan Xiong Jia Pan Yong Zhang Peipei Liu Guizhen Wu Guolan Gao Guolan Gao |
| author_sort | Yichan Zhang |
| collection | DOAJ |
| description | Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. After studying 602 unvaccinated Chinese women using 16S rRNA to detect cervical-vaginal microecology, we analyzed the relationship between HPV infection and vaginal microecology including 20 HPV types. In Chinese women, L. gasseri–dominated and L. jensenii–dominated clusters were significantly absence. Microbial alpha diversity was significantly higher in HPV-infected and cervical intraepithelial neoplasia (CIN)–diagnosed groups than in healthy control group. Certain bacteria were associated with HPV infection and CIN, including Streptococcus, Prevotella, Chlamydia, Bifidobacterium, Ralstonia, and Aerococcus. With the development of disease, the proportions of community state type III (CST-III) and CST-IV-B gradually increased, whereas the proportions of CST-I and CST-IV-A gradually decreased. In addition, age was an influential factor for HPV infection. With aging, the probability of HPV infection and the proportion of CST-IV-B increase. In conclusion, our study was a large cross-sectional study that evaluated the relationship between vaginal microbiota and HPV infection, and brought essential comparable data. |
| first_indexed | 2024-04-12T13:43:37Z |
| format | Article |
| id | doaj.art-37235053eaec40e69c40fd66b49c9a97 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-12T13:43:37Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-37235053eaec40e69c40fd66b49c9a972022-12-22T03:30:46ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-06-011210.3389/fcimb.2022.814668814668Vaginal Microbiota Changes Caused by HPV Infection in Chinese WomenYichan Zhang0Yichan Zhang1Xiaolin Xu2Xiaolin Xu3Liqun Yu4Xingxian Shi5Min Min6Lijuan Xiong7Jia Pan8Yong Zhang9Peipei Liu10Guizhen Wu11Guolan Gao12Guolan Gao13Savaid Medical School, University of Chinese Academy of Sciences, Beijing, ChinaNational Health Commission of the People’s Republic of China (NHC) Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaSavaid Medical School, University of Chinese Academy of Sciences, Beijing, ChinaNational Health Commission of the People’s Republic of China (NHC) Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaDepartment of Obstetrics and Gynecology, Aviation General Hospital of China Medical University, Beijing, ChinaDepartment of Obstetrics and Gynecology, Aviation General Hospital of China Medical University, Beijing, ChinaDepartment of Obstetrics and Gynecology, Aviation General Hospital of China Medical University, Beijing, ChinaDepartment of Obstetrics and Gynecology, Aviation General Hospital of China Medical University, Beijing, ChinaDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, United StatesNational Health Commission of the People’s Republic of China (NHC) Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Health Commission of the People’s Republic of China (NHC) Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Health Commission of the People’s Republic of China (NHC) Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaSavaid Medical School, University of Chinese Academy of Sciences, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking University International Hospital, The Eight Clinical Medical College, Beijing, ChinaHuman papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. After studying 602 unvaccinated Chinese women using 16S rRNA to detect cervical-vaginal microecology, we analyzed the relationship between HPV infection and vaginal microecology including 20 HPV types. In Chinese women, L. gasseri–dominated and L. jensenii–dominated clusters were significantly absence. Microbial alpha diversity was significantly higher in HPV-infected and cervical intraepithelial neoplasia (CIN)–diagnosed groups than in healthy control group. Certain bacteria were associated with HPV infection and CIN, including Streptococcus, Prevotella, Chlamydia, Bifidobacterium, Ralstonia, and Aerococcus. With the development of disease, the proportions of community state type III (CST-III) and CST-IV-B gradually increased, whereas the proportions of CST-I and CST-IV-A gradually decreased. In addition, age was an influential factor for HPV infection. With aging, the probability of HPV infection and the proportion of CST-IV-B increase. In conclusion, our study was a large cross-sectional study that evaluated the relationship between vaginal microbiota and HPV infection, and brought essential comparable data.https://www.frontiersin.org/articles/10.3389/fcimb.2022.814668/fullHPV infectioncervical intraepithelial neoplasiavaginal microbiotaageL. gasseri–dominatedcommunity state types (CST) |
| spellingShingle | Yichan Zhang Yichan Zhang Xiaolin Xu Xiaolin Xu Liqun Yu Xingxian Shi Min Min Lijuan Xiong Jia Pan Yong Zhang Peipei Liu Guizhen Wu Guolan Gao Guolan Gao Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women Frontiers in Cellular and Infection Microbiology HPV infection cervical intraepithelial neoplasia vaginal microbiota age L. gasseri–dominated community state types (CST) |
| title | Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women |
| title_full | Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women |
| title_fullStr | Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women |
| title_full_unstemmed | Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women |
| title_short | Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women |
| title_sort | vaginal microbiota changes caused by hpv infection in chinese women |
| topic | HPV infection cervical intraepithelial neoplasia vaginal microbiota age L. gasseri–dominated community state types (CST) |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.814668/full |
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