Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble Drugs
Nanoconjugations have been demonstrated to be a dominant strategy for drug delivery and biomedical applications. In this review, we intend to describe several strategies for drug formulation, especially to improve the bioavailability of poorly water-soluble molecules for future application in the th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/11/7/325 |
| _version_ | 1828153251083583488 |
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| author | Thao T. D. Tran Phuong H. L. Tran |
| author_facet | Thao T. D. Tran Phuong H. L. Tran |
| author_sort | Thao T. D. Tran |
| collection | DOAJ |
| description | Nanoconjugations have been demonstrated to be a dominant strategy for drug delivery and biomedical applications. In this review, we intend to describe several strategies for drug formulation, especially to improve the bioavailability of poorly water-soluble molecules for future application in the therapy of numerous diseases. The context of current studies will give readers an overview of the conjugation strategies for fabricating nanoparticles, which have expanded from conjugated materials to the surface conjugation of nanovehicles. Moreover, nanoconjugates for theranostics are also discussed and highlighted. Overall, these state-of-the-art conjugation methods and these techniques and applications for nanoparticulate systems of poorly water-soluble drugs will inspire scientists to explore and discover more productive techniques and methodologies for drug development. |
| first_indexed | 2024-04-11T22:22:42Z |
| format | Article |
| id | doaj.art-3725b9fa189f4f95b432194c7353c44a |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T22:22:42Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-3725b9fa189f4f95b432194c7353c44a2022-12-22T04:00:01ZengMDPI AGPharmaceutics1999-49232019-07-0111732510.3390/pharmaceutics11070325pharmaceutics11070325Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble DrugsThao T. D. Tran0Phuong H. L. Tran1Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, VietnamSchool of Medicine, Deakin University, Geelong 3216, AustraliaNanoconjugations have been demonstrated to be a dominant strategy for drug delivery and biomedical applications. In this review, we intend to describe several strategies for drug formulation, especially to improve the bioavailability of poorly water-soluble molecules for future application in the therapy of numerous diseases. The context of current studies will give readers an overview of the conjugation strategies for fabricating nanoparticles, which have expanded from conjugated materials to the surface conjugation of nanovehicles. Moreover, nanoconjugates for theranostics are also discussed and highlighted. Overall, these state-of-the-art conjugation methods and these techniques and applications for nanoparticulate systems of poorly water-soluble drugs will inspire scientists to explore and discover more productive techniques and methodologies for drug development.https://www.mdpi.com/1999-4923/11/7/325nanoconjugatenanotechnologypoorly water-soluble drugstheranosticdrug deliverybiomedical applications |
| spellingShingle | Thao T. D. Tran Phuong H. L. Tran Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble Drugs Pharmaceutics nanoconjugate nanotechnology poorly water-soluble drugs theranostic drug delivery biomedical applications |
| title | Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble Drugs |
| title_full | Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble Drugs |
| title_fullStr | Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble Drugs |
| title_full_unstemmed | Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble Drugs |
| title_short | Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble Drugs |
| title_sort | nanoconjugation and encapsulation strategies for improving drug delivery and therapeutic efficacy of poorly water soluble drugs |
| topic | nanoconjugate nanotechnology poorly water-soluble drugs theranostic drug delivery biomedical applications |
| url | https://www.mdpi.com/1999-4923/11/7/325 |
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