Expression and Clinical Significance of LC-3 and P62 in Non-small Cell Lung Cancer
Background and objective LC-3 and P62, two of important autophagy-related proteins, were reported highly expressed in many kinds of human malignancies and associated with outcomes of the patients. The purpose of this study was to investigate the expression status of LC-3 and P62 in non-small cell lu...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2018-06-01
|
| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2018.06.04 |
| _version_ | 1819237651278987264 |
|---|---|
| author | Cong WANG Yongwen LI Ying LI Hao GONG Hongbing ZHANG Yin YUAN Weiting LI Hongyu LIU Jun CHEN |
| author_facet | Cong WANG Yongwen LI Ying LI Hao GONG Hongbing ZHANG Yin YUAN Weiting LI Hongyu LIU Jun CHEN |
| author_sort | Cong WANG |
| collection | DOAJ |
| description | Background and objective LC-3 and P62, two of important autophagy-related proteins, were reported highly expressed in many kinds of human malignancies and associated with outcomes of the patients. The purpose of this study was to investigate the expression status of LC-3 and P62 in non-small cell lung cancer patients and define the clinical-pathologic features. Methods 66 cases of non-small cell lung cancer patients were employed. The expression of LC-3 and P62 were detected by immunohistochemistry. Results LC-3 was positive stained in 27 out of 66 cases (40.9%) and P62 was positive stained in 43 out of 66 cases (65.2%). LC-3 positive staining was more frequently in squamous cell carcinoma patients (P<0.05); while P62 positive staining was more frequently in late-stage adenocarcinoma patients with metastasis (P<0.05). There was a significant negative correlation between LC-3 and P62 expressions in non-small cell lung cancer tissues (rs=-0.065, P<0.001). Kaplan-Meier analysis showed that patients with positive LC-3 expression had favorable clinical outcomes compared with the patients with negative LC-3 expression (P<0.05). Conclusion LC-3 and P62 showed abnormal expression in non-small cell lung cancer tissues, suggesting that autophagy is involved in the occurrence and development of NSCLC. |
| first_indexed | 2024-12-23T13:23:43Z |
| format | Article |
| id | doaj.art-372982bdc24847e5b1bea47997168ad7 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-23T13:23:43Z |
| publishDate | 2018-06-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-372982bdc24847e5b1bea47997168ad72022-12-21T17:45:22ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872018-06-0121644545010.3779/j.issn.1009-3419.2018.06.04Expression and Clinical Significance of LC-3 and P62
in Non-small Cell Lung CancerCong WANG0Yongwen LI1Ying LI2Hao GONG3Hongbing ZHANG4Yin YUAN5Weiting LI6Hongyu LIU7Jun CHEN8Department of Lung Cancer SurgeryTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, ChinaTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Lung Cancer SurgeryDepartment of Lung Cancer SurgeryDepartment of Lung Cancer SurgeryDepartment of Lung Cancer SurgeryTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, ChinaDepartment of Lung Cancer SurgeryBackground and objective LC-3 and P62, two of important autophagy-related proteins, were reported highly expressed in many kinds of human malignancies and associated with outcomes of the patients. The purpose of this study was to investigate the expression status of LC-3 and P62 in non-small cell lung cancer patients and define the clinical-pathologic features. Methods 66 cases of non-small cell lung cancer patients were employed. The expression of LC-3 and P62 were detected by immunohistochemistry. Results LC-3 was positive stained in 27 out of 66 cases (40.9%) and P62 was positive stained in 43 out of 66 cases (65.2%). LC-3 positive staining was more frequently in squamous cell carcinoma patients (P<0.05); while P62 positive staining was more frequently in late-stage adenocarcinoma patients with metastasis (P<0.05). There was a significant negative correlation between LC-3 and P62 expressions in non-small cell lung cancer tissues (rs=-0.065, P<0.001). Kaplan-Meier analysis showed that patients with positive LC-3 expression had favorable clinical outcomes compared with the patients with negative LC-3 expression (P<0.05). Conclusion LC-3 and P62 showed abnormal expression in non-small cell lung cancer tissues, suggesting that autophagy is involved in the occurrence and development of NSCLC.http://dx.doi.org/10.3779/j.issn.1009-3419.2018.06.04LC-3P62AutophagyNon-small cell lung cancerImmunohistochemistry |
| spellingShingle | Cong WANG Yongwen LI Ying LI Hao GONG Hongbing ZHANG Yin YUAN Weiting LI Hongyu LIU Jun CHEN Expression and Clinical Significance of LC-3 and P62 in Non-small Cell Lung Cancer Chinese Journal of Lung Cancer LC-3 P62 Autophagy Non-small cell lung cancer Immunohistochemistry |
| title | Expression and Clinical Significance of LC-3 and P62
in Non-small Cell Lung Cancer |
| title_full | Expression and Clinical Significance of LC-3 and P62
in Non-small Cell Lung Cancer |
| title_fullStr | Expression and Clinical Significance of LC-3 and P62
in Non-small Cell Lung Cancer |
| title_full_unstemmed | Expression and Clinical Significance of LC-3 and P62
in Non-small Cell Lung Cancer |
| title_short | Expression and Clinical Significance of LC-3 and P62
in Non-small Cell Lung Cancer |
| title_sort | expression and clinical significance of lc 3 and p62
in non small cell lung cancer |
| topic | LC-3 P62 Autophagy Non-small cell lung cancer Immunohistochemistry |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2018.06.04 |
| work_keys_str_mv | AT congwang expressionandclinicalsignificanceoflc3andp62innonsmallcelllungcancer AT yongwenli expressionandclinicalsignificanceoflc3andp62innonsmallcelllungcancer AT yingli expressionandclinicalsignificanceoflc3andp62innonsmallcelllungcancer AT haogong expressionandclinicalsignificanceoflc3andp62innonsmallcelllungcancer AT hongbingzhang expressionandclinicalsignificanceoflc3andp62innonsmallcelllungcancer AT yinyuan expressionandclinicalsignificanceoflc3andp62innonsmallcelllungcancer AT weitingli expressionandclinicalsignificanceoflc3andp62innonsmallcelllungcancer AT hongyuliu expressionandclinicalsignificanceoflc3andp62innonsmallcelllungcancer AT junchen expressionandclinicalsignificanceoflc3andp62innonsmallcelllungcancer |