The bio-distribution of the antidepressant clomipramine is modulated by chronic stress in mice: Effects on behavior

The bio-distribution of the antidepressant clomipramine is modulated by chronic stress in mice: Effects on behavior

Major depression is one of the most common psychiatric disorders, severely affecting the quality of life of millions of people worldwide. Despite the availability of several classes of antidepressants, treatment efficacy is still very variable and many patients do not respond to the treatment. Clomi...

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Bibliographic Details
Main Authors: Georgia eBalsevich, Christian eNamendorf, Tamara eGerlach, Manfred eUhr, Mathias V. Schmidt
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Clomipramine
Tissue Distribution
mouse model
Antidepressants
chronic social defeat stress
Metabolic ratio
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00445/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00445/full

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