In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo
The leaf essential oils of Cymbopogon citratus L. and Cymbopogon nardus L.(Poaceae) from Togo were steam-distilled, analyzed for percentage composition and investigated in vitro for their potential cytotoxic activity on human epidermic cell line HaCat. The percentage composition showed that the main...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2009-06-01
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| Series: | Bangladesh Journal of Pharmacology |
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| Online Access: | http://www.bdjpharmacol.com/0401/29.pdf |
| _version_ | 1819082966469443584 |
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| author | Koffi Koba Sanda Komla Guyon Catherine Raynaud Christine Chaumont Jean-Pierre Nicod Laurence |
| author_facet | Koffi Koba Sanda Komla Guyon Catherine Raynaud Christine Chaumont Jean-Pierre Nicod Laurence |
| author_sort | Koffi Koba |
| collection | DOAJ |
| description | The leaf essential oils of Cymbopogon citratus L. and Cymbopogon nardus L.(Poaceae) from Togo were steam-distilled, analyzed for percentage composition and investigated in vitro for their potential cytotoxic activity on human epidermic cell line HaCat. The percentage composition showed that the main constituents of essential oils samples were respectively geranial (45.2%), neral(32.4%) and myrcène (10.2%) for C. citratus essential oil and citronellal (35.5%), geraniol (27.9%) and citronellol (10.7%) for that of C. nardus. The in vitro cytotoxicity bioassays on human epidermic cell line HaCaT revealed that the toxicityof the essential oil from C. citratus (IC50: 150 μL.mL-1) was higher than that of the essential oil from C. nardus (IC50: 450 μL.mL-1). Pure commercial neral, geranial, and citronellal standards showed respectively the following IC50 values: 100, 250 and 300 μL.mL-1). Conversely, pure citronellol standard appeared almost non-toxic (IC50>1000 μL.mL-1), proving the major role played in synergyby neral and geranial in the overall toxicity showed by the citratus oil sample tested in this work. |
| first_indexed | 2024-12-21T20:25:04Z |
| format | Article |
| id | doaj.art-372a6fbf65fe42e0a95ebb84d9524ed0 |
| institution | Directory Open Access Journal |
| issn | 1991-007X 1991-0088 |
| language | English |
| last_indexed | 2024-12-21T20:25:04Z |
| publishDate | 2009-06-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-372a6fbf65fe42e0a95ebb84d9524ed02022-12-21T18:51:23ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-007X1991-00882009-06-01412934In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from TogoKoffi KobaSanda KomlaGuyon CatherineRaynaud ChristineChaumont Jean-PierreNicod LaurenceThe leaf essential oils of Cymbopogon citratus L. and Cymbopogon nardus L.(Poaceae) from Togo were steam-distilled, analyzed for percentage composition and investigated in vitro for their potential cytotoxic activity on human epidermic cell line HaCat. The percentage composition showed that the main constituents of essential oils samples were respectively geranial (45.2%), neral(32.4%) and myrcène (10.2%) for C. citratus essential oil and citronellal (35.5%), geraniol (27.9%) and citronellol (10.7%) for that of C. nardus. The in vitro cytotoxicity bioassays on human epidermic cell line HaCaT revealed that the toxicityof the essential oil from C. citratus (IC50: 150 μL.mL-1) was higher than that of the essential oil from C. nardus (IC50: 450 μL.mL-1). Pure commercial neral, geranial, and citronellal standards showed respectively the following IC50 values: 100, 250 and 300 μL.mL-1). Conversely, pure citronellol standard appeared almost non-toxic (IC50>1000 μL.mL-1), proving the major role played in synergyby neral and geranial in the overall toxicity showed by the citratus oil sample tested in this work.http://www.bdjpharmacol.com/0401/29.pdfCymbopogon citratusCymbopogon nardusCytotoxicityEssential oilHaCaT cell line |
| spellingShingle | Koffi Koba Sanda Komla Guyon Catherine Raynaud Christine Chaumont Jean-Pierre Nicod Laurence In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo Bangladesh Journal of Pharmacology Cymbopogon citratus Cymbopogon nardus Cytotoxicity Essential oil HaCaT cell line |
| title | In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo |
| title_full | In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo |
| title_fullStr | In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo |
| title_full_unstemmed | In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo |
| title_short | In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo |
| title_sort | in vitro cytotoxic activity of cymbopogon citratus l and cymbopogon nardus l essential oils from togo |
| topic | Cymbopogon citratus Cymbopogon nardus Cytotoxicity Essential oil HaCaT cell line |
| url | http://www.bdjpharmacol.com/0401/29.pdf |
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