Outcomes of normotensive IgA nephropathy patients with mild proteinuria who have impaired renal function
Purpose: Typically, IgA nephropathy is a slowly progressive type of glomerulonephritis. High-grade proteinuria and hypertension are predictors of reduced kidney function. However, we found some normotensive patients with mild proteinuria could exhibit impaired renal function at the time of IgAN diag...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0886022X.2019.1654512 |
| _version_ | 1819081923877666816 |
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| author | Min Tan Jing Fang Qianqian Xu Cong Zhang Guming Zou Min Wang Wenge Li |
| author_facet | Min Tan Jing Fang Qianqian Xu Cong Zhang Guming Zou Min Wang Wenge Li |
| author_sort | Min Tan |
| collection | DOAJ |
| description | Purpose: Typically, IgA nephropathy is a slowly progressive type of glomerulonephritis. High-grade proteinuria and hypertension are predictors of reduced kidney function. However, we found some normotensive patients with mild proteinuria could exhibit impaired renal function at the time of IgAN diagnosis. We therefore conduct a study to highlight the occurrence of these cases and to define their clinical characteristics and outcomes. Methods: The clinical, laboratory, pathological manifestations and outcomes of these IgAN patients were collected and were compared with normotensive IgA nephropathy patients with mild proteinuria and normal renal function. Patients were analyzed according to different pathological characteristics. Survival curves were constructed according to the Kaplan–Meier method. Results: Of all normotensive IgA nephropathy patients with mild proteinuria, 108 (10.1%) patients had impaired renal function. Ischemic sclerosis (79 patients) and fibrous crescent (25 patients) were the main pathological characteristics. Macroscopic hematuria (1.3%), prodromal infection (13.9%) and high serum IgA (11.4%) were significantly lower prevalences, but only proteinuria (26.6%) was more common in ischemic sclerosis group patients. Only hematuria were not found in ischemic sclerosis group and crescent group patients. The median follow-up were about 5 years. Patients in crescent group had a poor outcome compared with patients in ischemic sclerosis group. Conclusions: Some normotensive IgA nephropathy patients with mild proteinuria had impaired renal function at diagnosis. Ischemic sclerosis and fibrous crescent were the main pathological features in these patients. Patients in the crescent group had a worse outcome than patients in the ischemic sclerosis group. |
| first_indexed | 2024-12-21T20:08:30Z |
| format | Article |
| id | doaj.art-372cdd8eadaa4875a00ece4cd735005a |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-21T20:08:30Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-372cdd8eadaa4875a00ece4cd735005a2022-12-21T18:51:47ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492019-01-0141187588210.1080/0886022X.2019.16545121654512Outcomes of normotensive IgA nephropathy patients with mild proteinuria who have impaired renal functionMin Tan0Jing Fang1Qianqian Xu2Cong Zhang3Guming Zou4Min Wang5Wenge Li6China-Japan Friendship Hospital, Health Ministry of ChinaChina-Japan Friendship Hospital, Health Ministry of ChinaChina-Japan Friendship Hospital, Health Ministry of ChinaChina-Japan Friendship Hospital, Health Ministry of ChinaChina-Japan Friendship Hospital, Health Ministry of ChinaChina-Japan Friendship Hospital, Health Ministry of ChinaChina-Japan Friendship Hospital, Health Ministry of ChinaPurpose: Typically, IgA nephropathy is a slowly progressive type of glomerulonephritis. High-grade proteinuria and hypertension are predictors of reduced kidney function. However, we found some normotensive patients with mild proteinuria could exhibit impaired renal function at the time of IgAN diagnosis. We therefore conduct a study to highlight the occurrence of these cases and to define their clinical characteristics and outcomes. Methods: The clinical, laboratory, pathological manifestations and outcomes of these IgAN patients were collected and were compared with normotensive IgA nephropathy patients with mild proteinuria and normal renal function. Patients were analyzed according to different pathological characteristics. Survival curves were constructed according to the Kaplan–Meier method. Results: Of all normotensive IgA nephropathy patients with mild proteinuria, 108 (10.1%) patients had impaired renal function. Ischemic sclerosis (79 patients) and fibrous crescent (25 patients) were the main pathological characteristics. Macroscopic hematuria (1.3%), prodromal infection (13.9%) and high serum IgA (11.4%) were significantly lower prevalences, but only proteinuria (26.6%) was more common in ischemic sclerosis group patients. Only hematuria were not found in ischemic sclerosis group and crescent group patients. The median follow-up were about 5 years. Patients in crescent group had a poor outcome compared with patients in ischemic sclerosis group. Conclusions: Some normotensive IgA nephropathy patients with mild proteinuria had impaired renal function at diagnosis. Ischemic sclerosis and fibrous crescent were the main pathological features in these patients. Patients in the crescent group had a worse outcome than patients in the ischemic sclerosis group.http://dx.doi.org/10.1080/0886022X.2019.1654512iga nephropathyproteinuriahypertensionrenal failurepathology |
| spellingShingle | Min Tan Jing Fang Qianqian Xu Cong Zhang Guming Zou Min Wang Wenge Li Outcomes of normotensive IgA nephropathy patients with mild proteinuria who have impaired renal function Renal Failure iga nephropathy proteinuria hypertension renal failure pathology |
| title | Outcomes of normotensive IgA nephropathy patients with mild proteinuria who have impaired renal function |
| title_full | Outcomes of normotensive IgA nephropathy patients with mild proteinuria who have impaired renal function |
| title_fullStr | Outcomes of normotensive IgA nephropathy patients with mild proteinuria who have impaired renal function |
| title_full_unstemmed | Outcomes of normotensive IgA nephropathy patients with mild proteinuria who have impaired renal function |
| title_short | Outcomes of normotensive IgA nephropathy patients with mild proteinuria who have impaired renal function |
| title_sort | outcomes of normotensive iga nephropathy patients with mild proteinuria who have impaired renal function |
| topic | iga nephropathy proteinuria hypertension renal failure pathology |
| url | http://dx.doi.org/10.1080/0886022X.2019.1654512 |
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