Dabigatran, a direct thrombin inhibitor, can be a life-saving treatment in heparin-induced thrombocytopenia
<div><p class="abstract"><strong>BACKGROUND:</strong> Several studies have emphasized thrombosis associated with thrombocytopenia as a potentially fatal complication of heparin. A number of agents are used for this condition. As a new oral, reversible direct thrombi...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Vesnu Publications
2013-01-01
|
| Series: | ARYA Atherosclerosis |
| Online Access: | http://arya.mui.ac.ir/index.php/arya/article/view/428 |
| _version_ | 1818842800188293120 |
|---|---|
| author | Ahmad Mirdamadi |
| author_facet | Ahmad Mirdamadi |
| author_sort | Ahmad Mirdamadi |
| collection | DOAJ |
| description | <div><p class="abstract"><strong>BACKGROUND:</strong> Several studies have emphasized thrombosis associated with thrombocytopenia as a potentially fatal complication of heparin. A number of agents are used for this condition. As a new oral, reversible direct thrombin inhibitor, dabigatran has been approved for short-term thromboprophylaxis after elective hip and knee replacement surgery. We present a case of dabigatran administration in a patient with femoral fracture.</p> <p class="abstract"><strong>CASE REPORT:</strong> A 67-year-old woman referred to the orthopedic ward of Shariati Hospital (Isfahan, Iran) due to femoral fracture following an accident. Immediately after surgery, she was found to be suffering from deep vein thrombosis (DVT) in her lower extremity despite sufficient prophylaxis by enoxaparin. Laboratory data showed severe thrombocytopenia. Considering the clinical history, an initial diagnosis of heparin-induced thrombocytopenia was made. Doppler ultrasound confirmed the diagnosis. Heparin was thus replaced with dabigatran which increased platelet count to the normal range and improved DVT.</p> <p class="abstract"><strong>CONCLUSION:</strong> Dabigatran can be a life-saving treatment in heparin-induced thrombocytopenia. However, it is contraindicated in patients with renal dysfunction since it may cause potentially catastrophic results.</p> <p class="abstract"> </p></div> <strong>Keywords:</strong> Heparin Induced Thrombocytopenia, Heparin, Enoxaparin, Dabigatran |
| first_indexed | 2024-12-19T04:47:44Z |
| format | Article |
| id | doaj.art-372d330673144995a64e6b7a9ce64564 |
| institution | Directory Open Access Journal |
| issn | 1735-3955 2251-6638 |
| language | English |
| last_indexed | 2024-12-19T04:47:44Z |
| publishDate | 2013-01-01 |
| publisher | Vesnu Publications |
| record_format | Article |
| series | ARYA Atherosclerosis |
| spelling | doaj.art-372d330673144995a64e6b7a9ce645642022-12-21T20:35:25ZengVesnu PublicationsARYA Atherosclerosis1735-39552251-66382013-01-0191112114363Dabigatran, a direct thrombin inhibitor, can be a life-saving treatment in heparin-induced thrombocytopeniaAhmad Mirdamadi0Assistant Professor, Department of Cardiology, School of Medicine, Najafabad Branch, Islamic Azad University, Isfahan, Iran<div><p class="abstract"><strong>BACKGROUND:</strong> Several studies have emphasized thrombosis associated with thrombocytopenia as a potentially fatal complication of heparin. A number of agents are used for this condition. As a new oral, reversible direct thrombin inhibitor, dabigatran has been approved for short-term thromboprophylaxis after elective hip and knee replacement surgery. We present a case of dabigatran administration in a patient with femoral fracture.</p> <p class="abstract"><strong>CASE REPORT:</strong> A 67-year-old woman referred to the orthopedic ward of Shariati Hospital (Isfahan, Iran) due to femoral fracture following an accident. Immediately after surgery, she was found to be suffering from deep vein thrombosis (DVT) in her lower extremity despite sufficient prophylaxis by enoxaparin. Laboratory data showed severe thrombocytopenia. Considering the clinical history, an initial diagnosis of heparin-induced thrombocytopenia was made. Doppler ultrasound confirmed the diagnosis. Heparin was thus replaced with dabigatran which increased platelet count to the normal range and improved DVT.</p> <p class="abstract"><strong>CONCLUSION:</strong> Dabigatran can be a life-saving treatment in heparin-induced thrombocytopenia. However, it is contraindicated in patients with renal dysfunction since it may cause potentially catastrophic results.</p> <p class="abstract"> </p></div> <strong>Keywords:</strong> Heparin Induced Thrombocytopenia, Heparin, Enoxaparin, Dabigatranhttp://arya.mui.ac.ir/index.php/arya/article/view/428 |
| spellingShingle | Ahmad Mirdamadi Dabigatran, a direct thrombin inhibitor, can be a life-saving treatment in heparin-induced thrombocytopenia ARYA Atherosclerosis |
| title | Dabigatran, a direct thrombin inhibitor, can be a life-saving treatment in heparin-induced thrombocytopenia |
| title_full | Dabigatran, a direct thrombin inhibitor, can be a life-saving treatment in heparin-induced thrombocytopenia |
| title_fullStr | Dabigatran, a direct thrombin inhibitor, can be a life-saving treatment in heparin-induced thrombocytopenia |
| title_full_unstemmed | Dabigatran, a direct thrombin inhibitor, can be a life-saving treatment in heparin-induced thrombocytopenia |
| title_short | Dabigatran, a direct thrombin inhibitor, can be a life-saving treatment in heparin-induced thrombocytopenia |
| title_sort | dabigatran a direct thrombin inhibitor can be a life saving treatment in heparin induced thrombocytopenia |
| url | http://arya.mui.ac.ir/index.php/arya/article/view/428 |
| work_keys_str_mv | AT ahmadmirdamadi dabigatranadirectthrombininhibitorcanbealifesavingtreatmentinheparininducedthrombocytopenia |