The Effects of Oral Silver Nanoparticles and Propolis on the Level of Lipid Peroxidation in Male Wistar Rats
Background: Oxidative stress is a leading factor in developing silver nanoparticle-induced toxicity. Objective: This study evaluated the effects of oral prescription of different doses of silver nanoparticles and propolis on lipid peroxidation in male Wistar rats. Methods: The male Wistar rats w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Qazvin University of Medical Sciences & Health Services
2021-09-01
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| Series: | The Journal of Qazvin University of Medical Sciences |
| Subjects: | |
| Online Access: | https://journal.qums.ac.ir/article-1-3213-en.html |
| Summary: | Background: Oxidative stress is a leading factor in developing silver nanoparticle-induced
toxicity.
Objective: This study evaluated the effects of oral prescription of different doses of silver
nanoparticles and propolis on lipid peroxidation in male Wistar rats.
Methods: The male Wistar rats were randomly divided into four groups. Control group and
three different treatment groups with oral prescription of 30 ppm, 60 ppm, and 60 ppm of silver
nanoparticles with 200 mg/kg of propolis. The serum level of Malondialdehyde (MDA) was measured
by Thiobarbituric Acid Reactive Substances (TBARS) assay using Thiobarbituric Acid (TBA).
Results: The serum level of MDA as a marker of lipid peroxidation in the control group was 1.92
mM/mL, and in other groups that received silver nanoparticles (30 ppm, 60 ppm, 60 ppm with
200 mg/kg propolis) were respectively 2.82, 3.83 and 2.62 mM/mL. MDA level also increased
at the doses of 30 ppm and 60 ppm compared to the control group and decreased when propolis
was prescribed with silver nanoparticles in the third group; however, its value did not reach the
level of the control group. Minimal levels of serum lipid peroxidation were observed when silver
and propolis nanoparticles were administered to male rats.
Conclusion: The mixture of silver nanoparticles and propolis reduces the toxic effects of silver
nanoparticles; it preserves and increases the efficiency of this compound in medical applications. |
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| ISSN: | 1561-3666 2228-7213 |