Spontaneous migraine attack causes alterations in default mode network connectivity: a resting-state fMRI case report
Abstract Background Although migraine is one of the most investigated neurologic disorders, we do not have a perfect neuroimaging biomarker for its pathophysiology. One option to improve our knowledge is to study resting-state functional connectivity in and out of headache pain. However, our underst...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-04-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-017-2484-1 |
| _version_ | 1818246545293705216 |
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| author | Andrea Edit Edes Lajos Rudolf Kozak Mate Magyar Terezia Zsombok Gyongyi Kokonyei Gyorgy Bagdy Gabriella Juhasz |
| author_facet | Andrea Edit Edes Lajos Rudolf Kozak Mate Magyar Terezia Zsombok Gyongyi Kokonyei Gyorgy Bagdy Gabriella Juhasz |
| author_sort | Andrea Edit Edes |
| collection | DOAJ |
| description | Abstract Background Although migraine is one of the most investigated neurologic disorders, we do not have a perfect neuroimaging biomarker for its pathophysiology. One option to improve our knowledge is to study resting-state functional connectivity in and out of headache pain. However, our understanding of the functional connectivity changes during spontaneous migraine attack is partial and incomplete. Case presentation Using resting-state functional magnetic resonance imaging we assessed a 24-year old woman affected by migraine without aura at two different times: during a spontaneous migraine attack and in interictal phase. Seed-to-voxel whole brain analysis was carried out using the posterior cingulate cortex as a seed, representing the default mode network (DMN). Our results showed decreased intrinsic connectivity within core regions of the DMN with an exception of a subsystem including the dorsal medial and superior frontal gyri, and the mid-temporal gyrus which is responsible for pain interpretation and control. In addition, increased connectivity between the DMN and pain and specific migraine-related areas, such as the pons and hypothalamus, developed during the spontaneous migraine attack. Conclusion Our preliminary results provide further support for the hypothesis that alterations of the DMN functional connectivity during migraine headache may lead to maladaptive top-down modulation of migraine pain-related areas which might be a specific biomarker for migraine. |
| first_indexed | 2024-12-12T14:50:31Z |
| format | Article |
| id | doaj.art-372f6f617a59445eaf17608b96b0f189 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-12T14:50:31Z |
| publishDate | 2017-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-372f6f617a59445eaf17608b96b0f1892022-12-22T00:21:01ZengBMCBMC Research Notes1756-05002017-04-011011510.1186/s13104-017-2484-1Spontaneous migraine attack causes alterations in default mode network connectivity: a resting-state fMRI case reportAndrea Edit Edes0Lajos Rudolf Kozak1Mate Magyar2Terezia Zsombok3Gyongyi Kokonyei4Gyorgy Bagdy5Gabriella Juhasz6MTA-SE-NAP B Genetic Brain Imaging Migraine Research Group, Hungarian Academy of Sciences, Semmelweis UniversityMTA-SE-NAP B Genetic Brain Imaging Migraine Research Group, Hungarian Academy of Sciences, Semmelweis UniversityMTA-SE-NAP B Genetic Brain Imaging Migraine Research Group, Hungarian Academy of Sciences, Semmelweis UniversityMTA-SE-NAP B Genetic Brain Imaging Migraine Research Group, Hungarian Academy of Sciences, Semmelweis UniversityMTA-SE-NAP B Genetic Brain Imaging Migraine Research Group, Hungarian Academy of Sciences, Semmelweis UniversityMTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis UniversityMTA-SE-NAP B Genetic Brain Imaging Migraine Research Group, Hungarian Academy of Sciences, Semmelweis UniversityAbstract Background Although migraine is one of the most investigated neurologic disorders, we do not have a perfect neuroimaging biomarker for its pathophysiology. One option to improve our knowledge is to study resting-state functional connectivity in and out of headache pain. However, our understanding of the functional connectivity changes during spontaneous migraine attack is partial and incomplete. Case presentation Using resting-state functional magnetic resonance imaging we assessed a 24-year old woman affected by migraine without aura at two different times: during a spontaneous migraine attack and in interictal phase. Seed-to-voxel whole brain analysis was carried out using the posterior cingulate cortex as a seed, representing the default mode network (DMN). Our results showed decreased intrinsic connectivity within core regions of the DMN with an exception of a subsystem including the dorsal medial and superior frontal gyri, and the mid-temporal gyrus which is responsible for pain interpretation and control. In addition, increased connectivity between the DMN and pain and specific migraine-related areas, such as the pons and hypothalamus, developed during the spontaneous migraine attack. Conclusion Our preliminary results provide further support for the hypothesis that alterations of the DMN functional connectivity during migraine headache may lead to maladaptive top-down modulation of migraine pain-related areas which might be a specific biomarker for migraine.http://link.springer.com/article/10.1186/s13104-017-2484-1NeuroimagingFunctional connectivityMigraineMigraine attackHeadache painPain processing |
| spellingShingle | Andrea Edit Edes Lajos Rudolf Kozak Mate Magyar Terezia Zsombok Gyongyi Kokonyei Gyorgy Bagdy Gabriella Juhasz Spontaneous migraine attack causes alterations in default mode network connectivity: a resting-state fMRI case report BMC Research Notes Neuroimaging Functional connectivity Migraine Migraine attack Headache pain Pain processing |
| title | Spontaneous migraine attack causes alterations in default mode network connectivity: a resting-state fMRI case report |
| title_full | Spontaneous migraine attack causes alterations in default mode network connectivity: a resting-state fMRI case report |
| title_fullStr | Spontaneous migraine attack causes alterations in default mode network connectivity: a resting-state fMRI case report |
| title_full_unstemmed | Spontaneous migraine attack causes alterations in default mode network connectivity: a resting-state fMRI case report |
| title_short | Spontaneous migraine attack causes alterations in default mode network connectivity: a resting-state fMRI case report |
| title_sort | spontaneous migraine attack causes alterations in default mode network connectivity a resting state fmri case report |
| topic | Neuroimaging Functional connectivity Migraine Migraine attack Headache pain Pain processing |
| url | http://link.springer.com/article/10.1186/s13104-017-2484-1 |
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