Taurine Reverses Oxidative Damages and Restores the Muscle Function in Overuse of Exercised Muscle
Exercise-induced oxidative stress is linked with the expression level of endogenous antioxidants, but these antioxidants cannot overcome all oxidative stress-related damages in the cells, particularly when cells are under physiological stress. Sometimes, compounds are needed for cellular function, w...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2020.582449/full |
| _version_ | 1819182200206131200 |
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| author | Anand Thirupathi Ricardo A. Pinho Julien S. Baker Bíró István Yaodong Gu |
| author_facet | Anand Thirupathi Ricardo A. Pinho Julien S. Baker Bíró István Yaodong Gu |
| author_sort | Anand Thirupathi |
| collection | DOAJ |
| description | Exercise-induced oxidative stress is linked with the expression level of endogenous antioxidants, but these antioxidants cannot overcome all oxidative stress-related damages in the cells, particularly when cells are under physiological stress. Sometimes, compounds are needed for cellular function, which are produced/activated within the cells, and these compounds can be synthesized by performing exercise, especially high-performance exercise. Taurine is a sulfur-containing amino acid used for various physiological functions. However, its synthesis and accumulation under the oxidative environment may be compromised. Recently, we have shown that taurine level is increased during exercise performance with a decrease in oxidative damage in overused muscles. Other studies have also shown that short-term supplementation with taurine increased physiological performance during severe work intensities, suggesting the role of taurine in improving muscle performance during exercise. However, its precursor cysteine is used in the synthesis of other compounds like GSH and Coenzyme A, which are important for regulating the redox system and energy homeostasis. It is, therefore, important to understand whether taurine synthesis within the cells can blunt the activity of other compounds that are beneficial in preventing oxidative damage during intense exercise. Furthermore, it is important to understand whether taurine supplementation can prevent the conditions observed in the physiological stress of muscles. This review discusses how taurine synthesis could alter exercise-induced ROS generation and the relationship between the physiological stress of muscle and subsequent improvements in exercise performance. |
| first_indexed | 2024-12-22T22:42:21Z |
| format | Article |
| id | doaj.art-37311692bdb848e28c08982212d99320 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-22T22:42:21Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-37311692bdb848e28c08982212d993202022-12-21T18:10:09ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-10-011110.3389/fphys.2020.582449582449Taurine Reverses Oxidative Damages and Restores the Muscle Function in Overuse of Exercised MuscleAnand Thirupathi0Ricardo A. Pinho1Julien S. Baker2Bíró István3Yaodong Gu4Faculty of Sports Science, Ningbo University, Ningbo, ChinaLaboratory of Exercise Biochemistry in Health, Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, BrazilDepartment of Sport, Physical Education and Health, Hong Kong Baptist University, Hong Kong, ChinaFaculty of Engineering, University of Szeged, Szeged, HungaryFaculty of Sports Science, Ningbo University, Ningbo, ChinaExercise-induced oxidative stress is linked with the expression level of endogenous antioxidants, but these antioxidants cannot overcome all oxidative stress-related damages in the cells, particularly when cells are under physiological stress. Sometimes, compounds are needed for cellular function, which are produced/activated within the cells, and these compounds can be synthesized by performing exercise, especially high-performance exercise. Taurine is a sulfur-containing amino acid used for various physiological functions. However, its synthesis and accumulation under the oxidative environment may be compromised. Recently, we have shown that taurine level is increased during exercise performance with a decrease in oxidative damage in overused muscles. Other studies have also shown that short-term supplementation with taurine increased physiological performance during severe work intensities, suggesting the role of taurine in improving muscle performance during exercise. However, its precursor cysteine is used in the synthesis of other compounds like GSH and Coenzyme A, which are important for regulating the redox system and energy homeostasis. It is, therefore, important to understand whether taurine synthesis within the cells can blunt the activity of other compounds that are beneficial in preventing oxidative damage during intense exercise. Furthermore, it is important to understand whether taurine supplementation can prevent the conditions observed in the physiological stress of muscles. This review discusses how taurine synthesis could alter exercise-induced ROS generation and the relationship between the physiological stress of muscle and subsequent improvements in exercise performance.https://www.frontiersin.org/articles/10.3389/fphys.2020.582449/fulltaurineexercisemuscle overuseoxidative stressantioxidants |
| spellingShingle | Anand Thirupathi Ricardo A. Pinho Julien S. Baker Bíró István Yaodong Gu Taurine Reverses Oxidative Damages and Restores the Muscle Function in Overuse of Exercised Muscle Frontiers in Physiology taurine exercise muscle overuse oxidative stress antioxidants |
| title | Taurine Reverses Oxidative Damages and Restores the Muscle Function in Overuse of Exercised Muscle |
| title_full | Taurine Reverses Oxidative Damages and Restores the Muscle Function in Overuse of Exercised Muscle |
| title_fullStr | Taurine Reverses Oxidative Damages and Restores the Muscle Function in Overuse of Exercised Muscle |
| title_full_unstemmed | Taurine Reverses Oxidative Damages and Restores the Muscle Function in Overuse of Exercised Muscle |
| title_short | Taurine Reverses Oxidative Damages and Restores the Muscle Function in Overuse of Exercised Muscle |
| title_sort | taurine reverses oxidative damages and restores the muscle function in overuse of exercised muscle |
| topic | taurine exercise muscle overuse oxidative stress antioxidants |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2020.582449/full |
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