Genotoxicity Evaluation of Titanium Dioxide Nanoparticles In Vivo and In Vitro: A Meta-Analysis
Background: Recent studies have raised concerns about genotoxic effects associated with titanium dioxide nanoparticles (TiO<sub>2</sub> NPs), which are commonly used. This meta-analysis aims to investigate the potential genotoxicity of TiO<sub>2</sub> NPs and explore influenc...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/11/11/882 |
| _version_ | 1797457605641109504 |
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| author | Yue Cao Jinyao Chen Qian Bian Junyu Ning Ling Yong Tong Ou Yan Song Sheng Wei |
| author_facet | Yue Cao Jinyao Chen Qian Bian Junyu Ning Ling Yong Tong Ou Yan Song Sheng Wei |
| author_sort | Yue Cao |
| collection | DOAJ |
| description | Background: Recent studies have raised concerns about genotoxic effects associated with titanium dioxide nanoparticles (TiO<sub>2</sub> NPs), which are commonly used. This meta-analysis aims to investigate the potential genotoxicity of TiO<sub>2</sub> NPs and explore influencing factors. Methods: This study systematically searched Chinese and English literature. The literature underwent quality evaluation, including reliability evaluation using the toxicological data reliability assessment method and relevance evaluation using routine evaluation forms. Meta-analysis and subgroup analyses were performed using R software, with the standardized mean difference (SMD) as the combined effect value. Results: A total of 26 studies met the inclusion criteria and passed the quality assessment. Meta-analysis results indicated that the SMD for each genotoxic endpoint was greater than 0. This finding implies a significant association between TiO<sub>2</sub> NP treatment and DNA damage and chromosome damage both in vivo and in vitro and gene mutation in vitro. Subgroup analysis revealed that short-term exposure to TiO<sub>2</sub> NPs increased DNA damage. Rats and cancer cells exhibited heightened susceptibility to DNA damage triggered by TiO<sub>2</sub> NPs (<i>p</i> < 0.05). Conclusions: TiO<sub>2</sub> NPs could induce genotoxicity, including DNA damage, chromosomal damage, and in vitro gene mutations. The mechanism of DNA damage response plays a key role in the genotoxicity induced by TiO<sub>2</sub> NPs. |
| first_indexed | 2024-03-09T16:24:24Z |
| format | Article |
| id | doaj.art-37313f2078fe4160a686091dc91ae4e2 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-09T16:24:24Z |
| publishDate | 2023-10-01 |
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| record_format | Article |
| series | Toxics |
| spelling | doaj.art-37313f2078fe4160a686091dc91ae4e22023-11-24T15:09:13ZengMDPI AGToxics2305-63042023-10-01111188210.3390/toxics11110882Genotoxicity Evaluation of Titanium Dioxide Nanoparticles In Vivo and In Vitro: A Meta-AnalysisYue Cao0Jinyao Chen1Qian Bian2Junyu Ning3Ling Yong4Tong Ou5Yan Song6Sheng Wei7Key Laboratory of Food Safety Risk Assessment, National Health Commission of the People’s Republic of China (China National Center for Food Safety Risk Assessment), Guangqu Road, Beijing 100022, ChinaDepartment of Nutrition, Food Safety and Toxicology, West China School of Public Health, Sichuan University, Yihuan Road, Chengdu 610041, ChinaInstitute of Toxicology and Risk Assessment, Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu Road, Nanjing 210009, ChinaInstitute of Toxicology, Beijing Center for Disease Prevention and Control, Hepingli Middle Street, Beijing 100013, ChinaKey Laboratory of Food Safety Risk Assessment, National Health Commission of the People’s Republic of China (China National Center for Food Safety Risk Assessment), Guangqu Road, Beijing 100022, ChinaKey Laboratory of Food Safety Risk Assessment, National Health Commission of the People’s Republic of China (China National Center for Food Safety Risk Assessment), Guangqu Road, Beijing 100022, ChinaKey Laboratory of Food Safety Risk Assessment, National Health Commission of the People’s Republic of China (China National Center for Food Safety Risk Assessment), Guangqu Road, Beijing 100022, ChinaSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road, Wuhan 430030, ChinaBackground: Recent studies have raised concerns about genotoxic effects associated with titanium dioxide nanoparticles (TiO<sub>2</sub> NPs), which are commonly used. This meta-analysis aims to investigate the potential genotoxicity of TiO<sub>2</sub> NPs and explore influencing factors. Methods: This study systematically searched Chinese and English literature. The literature underwent quality evaluation, including reliability evaluation using the toxicological data reliability assessment method and relevance evaluation using routine evaluation forms. Meta-analysis and subgroup analyses were performed using R software, with the standardized mean difference (SMD) as the combined effect value. Results: A total of 26 studies met the inclusion criteria and passed the quality assessment. Meta-analysis results indicated that the SMD for each genotoxic endpoint was greater than 0. This finding implies a significant association between TiO<sub>2</sub> NP treatment and DNA damage and chromosome damage both in vivo and in vitro and gene mutation in vitro. Subgroup analysis revealed that short-term exposure to TiO<sub>2</sub> NPs increased DNA damage. Rats and cancer cells exhibited heightened susceptibility to DNA damage triggered by TiO<sub>2</sub> NPs (<i>p</i> < 0.05). Conclusions: TiO<sub>2</sub> NPs could induce genotoxicity, including DNA damage, chromosomal damage, and in vitro gene mutations. The mechanism of DNA damage response plays a key role in the genotoxicity induced by TiO<sub>2</sub> NPs.https://www.mdpi.com/2305-6304/11/11/882titanium dioxidenanoparticlesgenotoxicityhazard evaluationmeta-analysis |
| spellingShingle | Yue Cao Jinyao Chen Qian Bian Junyu Ning Ling Yong Tong Ou Yan Song Sheng Wei Genotoxicity Evaluation of Titanium Dioxide Nanoparticles In Vivo and In Vitro: A Meta-Analysis Toxics titanium dioxide nanoparticles genotoxicity hazard evaluation meta-analysis |
| title | Genotoxicity Evaluation of Titanium Dioxide Nanoparticles In Vivo and In Vitro: A Meta-Analysis |
| title_full | Genotoxicity Evaluation of Titanium Dioxide Nanoparticles In Vivo and In Vitro: A Meta-Analysis |
| title_fullStr | Genotoxicity Evaluation of Titanium Dioxide Nanoparticles In Vivo and In Vitro: A Meta-Analysis |
| title_full_unstemmed | Genotoxicity Evaluation of Titanium Dioxide Nanoparticles In Vivo and In Vitro: A Meta-Analysis |
| title_short | Genotoxicity Evaluation of Titanium Dioxide Nanoparticles In Vivo and In Vitro: A Meta-Analysis |
| title_sort | genotoxicity evaluation of titanium dioxide nanoparticles in vivo and in vitro a meta analysis |
| topic | titanium dioxide nanoparticles genotoxicity hazard evaluation meta-analysis |
| url | https://www.mdpi.com/2305-6304/11/11/882 |
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