Enhancement of graphene oxide through β-cyclodextrin composite to sensitive analysis of an antidepressant: Sulpiride
In this study, the electrochemical behavior of sulpiride (SUL) was examined deeply by using pyrolytic graphite electrode modified with graphene oxide (GO) and β-cyclodextrin (β-CD). The developed nanosensor indicated considerable impact by significantly increasing the signal of SUL compared with the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2021-03-01
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| Series: | Open Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/chem-2021-0030 |
| _version_ | 1798030112366526464 |
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| author | Urcuk Ayca Karadurmus Leyla Bakirhan Nurgul K. Ozkan Sibel A. |
| author_facet | Urcuk Ayca Karadurmus Leyla Bakirhan Nurgul K. Ozkan Sibel A. |
| author_sort | Urcuk Ayca |
| collection | DOAJ |
| description | In this study, the electrochemical behavior of sulpiride (SUL) was examined deeply by using pyrolytic graphite electrode modified with graphene oxide (GO) and β-cyclodextrin (β-CD). The developed nanosensor indicated considerable impact by significantly increasing the signal of SUL compared with the bare electrode. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV) methods were utilized to investigate the SUL electrochemical analysis in aqueous solutions. Under optimum experimental conditions, calibration plot for SUL with a limit of detection of 2.83 × 10−9 M was obtained at accumulation time of the 30 s using square wave adsorptive stripping voltammetric technique (AdSSWV) in the range of 1.0 × 10−7 to 5.0 × 10−5 M. The effects of accumulation potential, accumulation time, pH, scan rate, electrolyte, and interfering agents were studied to obtain the intensive peak signal of the analyte. The presented method is validated and successfully performed for the determination of the SUL tablet and capsule. The fabricated nanosensor was carried out for the detection of SUL in the urine. Excellent recoveries among 104.37, 103.82, and 101.95% were obtained for tablet and capsule forms and urine analysis. |
| first_indexed | 2024-04-11T19:36:03Z |
| format | Article |
| id | doaj.art-37322d8b4c5d4b3e959973c0ee21b400 |
| institution | Directory Open Access Journal |
| issn | 2391-5420 |
| language | English |
| last_indexed | 2024-04-11T19:36:03Z |
| publishDate | 2021-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Chemistry |
| spelling | doaj.art-37322d8b4c5d4b3e959973c0ee21b4002022-12-22T04:06:52ZengDe GruyterOpen Chemistry2391-54202021-03-0119122823610.1515/chem-2021-0030Enhancement of graphene oxide through β-cyclodextrin composite to sensitive analysis of an antidepressant: SulpirideUrcuk Ayca0Karadurmus Leyla1Bakirhan Nurgul K.2Ozkan Sibel A.3Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, TurkeyDepartment of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, TurkeyDepartment of Analytical Chemistry, Gulhane Faculty of Pharmacy, University of Health Sciences, Ankara, TurkeyDepartment of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, TurkeyIn this study, the electrochemical behavior of sulpiride (SUL) was examined deeply by using pyrolytic graphite electrode modified with graphene oxide (GO) and β-cyclodextrin (β-CD). The developed nanosensor indicated considerable impact by significantly increasing the signal of SUL compared with the bare electrode. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV) methods were utilized to investigate the SUL electrochemical analysis in aqueous solutions. Under optimum experimental conditions, calibration plot for SUL with a limit of detection of 2.83 × 10−9 M was obtained at accumulation time of the 30 s using square wave adsorptive stripping voltammetric technique (AdSSWV) in the range of 1.0 × 10−7 to 5.0 × 10−5 M. The effects of accumulation potential, accumulation time, pH, scan rate, electrolyte, and interfering agents were studied to obtain the intensive peak signal of the analyte. The presented method is validated and successfully performed for the determination of the SUL tablet and capsule. The fabricated nanosensor was carried out for the detection of SUL in the urine. Excellent recoveries among 104.37, 103.82, and 101.95% were obtained for tablet and capsule forms and urine analysis.https://doi.org/10.1515/chem-2021-0030sulpiridenanosensorelectrochemistrygraphene oxidepyrolytic graphite electrode |
| spellingShingle | Urcuk Ayca Karadurmus Leyla Bakirhan Nurgul K. Ozkan Sibel A. Enhancement of graphene oxide through β-cyclodextrin composite to sensitive analysis of an antidepressant: Sulpiride Open Chemistry sulpiride nanosensor electrochemistry graphene oxide pyrolytic graphite electrode |
| title | Enhancement of graphene oxide through β-cyclodextrin composite to sensitive analysis of an antidepressant: Sulpiride |
| title_full | Enhancement of graphene oxide through β-cyclodextrin composite to sensitive analysis of an antidepressant: Sulpiride |
| title_fullStr | Enhancement of graphene oxide through β-cyclodextrin composite to sensitive analysis of an antidepressant: Sulpiride |
| title_full_unstemmed | Enhancement of graphene oxide through β-cyclodextrin composite to sensitive analysis of an antidepressant: Sulpiride |
| title_short | Enhancement of graphene oxide through β-cyclodextrin composite to sensitive analysis of an antidepressant: Sulpiride |
| title_sort | enhancement of graphene oxide through β cyclodextrin composite to sensitive analysis of an antidepressant sulpiride |
| topic | sulpiride nanosensor electrochemistry graphene oxide pyrolytic graphite electrode |
| url | https://doi.org/10.1515/chem-2021-0030 |
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