Clinical implication of the advanced lung cancer inflammation index in patients with right-sided colon cancer after complete mesocolic excision: a propensity score-matched analysis
Abstract Background This study aimed to assess the clinical implications of the advanced lung cancer inflammation index (ALI) in patients with right-sided colon cancer (RCC) after complete mesocolic excision (CME). Methods A total of 441 patients with RCC who underwent CME were included. The optimal...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-022-02712-0 |
| _version_ | 1811315090120507392 |
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| author | Yu Deng Yanwu Sun Yu Lin Ying Huang Pan Chi |
| author_facet | Yu Deng Yanwu Sun Yu Lin Ying Huang Pan Chi |
| author_sort | Yu Deng |
| collection | DOAJ |
| description | Abstract Background This study aimed to assess the clinical implications of the advanced lung cancer inflammation index (ALI) in patients with right-sided colon cancer (RCC) after complete mesocolic excision (CME). Methods A total of 441 patients with RCC who underwent CME were included. The optimal cut-off value for the ALI was determined using the X-tile software. Logistic and Cox regression analyses were used to identify risk factors for postoperative complications and long-term outcomes. Predictive nomograms for overall survival (OS) and disease-free survival (DFS) were constructed after propensity score matching (PSM), and their performance was assessed using the net reclassification improvement index (NRI), integrated discrimination improvement index (IDI), and time-dependent receiver operating characteristic (time-ROC) curve analysis. Results The optimal preoperative ALI cut-off value was 36.3. After PSM, ASA classification 3/4, operative duration, and a low ALI were independently associated with postoperative complications in the multivariate analysis (all P<0.05). Cox regression analysis revealed that an age >60 years, a carbohydrate antigen 19-9 (CA19-9) level >37 U/mL, pathological N+ stage, and a low ALI were independently correlated with OS (all P<0.05). A CA19-9 level >37 U/mL, pathological N+ stage, lymphovascular invasion, and a low ALI were independent predictors of DFS (all P<0.05). Predictive nomograms for OS and DFS were constructed using PSM. Furthermore, a nomogram combined with the ALI was consistently superior to a non-ALI nomogram or the pathological tumor-node-metastasis classification based on the NRI, IDI, and time-ROC curve analysis after PSM (all P<0.05). Conclusion The ALI was an effective indicator for predicting short- and long-term outcomes in patients with RCC. |
| first_indexed | 2024-04-13T11:24:04Z |
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| id | doaj.art-3736c218f3df48babe32940d4db450bf |
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| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-13T11:24:04Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
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| series | World Journal of Surgical Oncology |
| spelling | doaj.art-3736c218f3df48babe32940d4db450bf2022-12-22T02:48:45ZengBMCWorld Journal of Surgical Oncology1477-78192022-08-0120111210.1186/s12957-022-02712-0Clinical implication of the advanced lung cancer inflammation index in patients with right-sided colon cancer after complete mesocolic excision: a propensity score-matched analysisYu Deng0Yanwu Sun1Yu Lin2Ying Huang3Pan Chi4Department of Colorectal Surgery, Fujian Medical University Union HospitalDepartment of Colorectal Surgery, Fujian Medical University Union HospitalDepartment of Colorectal Surgery, Fujian Medical University Union HospitalDepartment of Colorectal Surgery, Fujian Medical University Union HospitalDepartment of Colorectal Surgery, Fujian Medical University Union HospitalAbstract Background This study aimed to assess the clinical implications of the advanced lung cancer inflammation index (ALI) in patients with right-sided colon cancer (RCC) after complete mesocolic excision (CME). Methods A total of 441 patients with RCC who underwent CME were included. The optimal cut-off value for the ALI was determined using the X-tile software. Logistic and Cox regression analyses were used to identify risk factors for postoperative complications and long-term outcomes. Predictive nomograms for overall survival (OS) and disease-free survival (DFS) were constructed after propensity score matching (PSM), and their performance was assessed using the net reclassification improvement index (NRI), integrated discrimination improvement index (IDI), and time-dependent receiver operating characteristic (time-ROC) curve analysis. Results The optimal preoperative ALI cut-off value was 36.3. After PSM, ASA classification 3/4, operative duration, and a low ALI were independently associated with postoperative complications in the multivariate analysis (all P<0.05). Cox regression analysis revealed that an age >60 years, a carbohydrate antigen 19-9 (CA19-9) level >37 U/mL, pathological N+ stage, and a low ALI were independently correlated with OS (all P<0.05). A CA19-9 level >37 U/mL, pathological N+ stage, lymphovascular invasion, and a low ALI were independent predictors of DFS (all P<0.05). Predictive nomograms for OS and DFS were constructed using PSM. Furthermore, a nomogram combined with the ALI was consistently superior to a non-ALI nomogram or the pathological tumor-node-metastasis classification based on the NRI, IDI, and time-ROC curve analysis after PSM (all P<0.05). Conclusion The ALI was an effective indicator for predicting short- and long-term outcomes in patients with RCC.https://doi.org/10.1186/s12957-022-02712-0Advanced lung cancer inflammation indexRight-sided colon cancerPostoperative complicationsPrognosisPropensity score-matched |
| spellingShingle | Yu Deng Yanwu Sun Yu Lin Ying Huang Pan Chi Clinical implication of the advanced lung cancer inflammation index in patients with right-sided colon cancer after complete mesocolic excision: a propensity score-matched analysis World Journal of Surgical Oncology Advanced lung cancer inflammation index Right-sided colon cancer Postoperative complications Prognosis Propensity score-matched |
| title | Clinical implication of the advanced lung cancer inflammation index in patients with right-sided colon cancer after complete mesocolic excision: a propensity score-matched analysis |
| title_full | Clinical implication of the advanced lung cancer inflammation index in patients with right-sided colon cancer after complete mesocolic excision: a propensity score-matched analysis |
| title_fullStr | Clinical implication of the advanced lung cancer inflammation index in patients with right-sided colon cancer after complete mesocolic excision: a propensity score-matched analysis |
| title_full_unstemmed | Clinical implication of the advanced lung cancer inflammation index in patients with right-sided colon cancer after complete mesocolic excision: a propensity score-matched analysis |
| title_short | Clinical implication of the advanced lung cancer inflammation index in patients with right-sided colon cancer after complete mesocolic excision: a propensity score-matched analysis |
| title_sort | clinical implication of the advanced lung cancer inflammation index in patients with right sided colon cancer after complete mesocolic excision a propensity score matched analysis |
| topic | Advanced lung cancer inflammation index Right-sided colon cancer Postoperative complications Prognosis Propensity score-matched |
| url | https://doi.org/10.1186/s12957-022-02712-0 |
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