Prevalence and factors associated with medication adherence in children with central precocious puberty: a cross-sectional study
Objectives: This study aimed to investigate the prevalence and influencing factors of medication adherence in children with central precocious puberty (CPP), and provide references for clinical practice.Methods: Children under 12 years of age with CPP and their caregivers at a women’s and children’s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1269158/full |
| _version_ | 1797362526706466816 |
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| author | Chunsong Yang Chunsong Yang Chunsong Yang Chunsong Yang Xia Song Xia Song Xia Song Xia Song Xia Song Jin Wu Lingli Zhang Lingli Zhang Lingli Zhang Lingli Zhang Lingli Zhang |
| author_facet | Chunsong Yang Chunsong Yang Chunsong Yang Chunsong Yang Xia Song Xia Song Xia Song Xia Song Xia Song Jin Wu Lingli Zhang Lingli Zhang Lingli Zhang Lingli Zhang Lingli Zhang |
| author_sort | Chunsong Yang |
| collection | DOAJ |
| description | Objectives: This study aimed to investigate the prevalence and influencing factors of medication adherence in children with central precocious puberty (CPP), and provide references for clinical practice.Methods: Children under 12 years of age with CPP and their caregivers at a women’s and children’s hospital were selected for a cross-sectional study from February to May 2023, and a questionnaire was used to collect basic characteristics of pediatric patients and their caregivers, information of medication, cognition of medication, and medication adherence. The 8-item Morisky Medication Adherence Scale (MMAS-8) was adopted to assess medication adherence, and the potential influencing factors were explored by univariate and multivariate analyses.Results: A total of 125 valid questionnaires were collected. The medication adherence rate of children with CPP reported by caregivers was 76.0%. The univariate analysis showed that the percentage of parental caregivers (p = 0.027), the age of caregivers (p = 0.029), the education level of caregivers (p = 0.001), the financial burden (p < 0.000), the incidence of adverse effects (p = 0.008), and the cognition of medication including the importance of medication (p = 0.002), the dosage of medication (p = 0.002), the adverse effects of medication (p = 0.007), the harm of non-compliance with medication (p < 0.000), and the evaluation of the price of medication (p = 0.003) in the poor adherence group were significantly inferior to those in the better adherence group. The multivariate analysis showed that the higher incidence of adverse effects (p = 0.20), not understanding the harm of non-compliance with medication (p = 0.004), and evaluation of the price of medication as expensive (p = 0.043) were independent risk factors for poor medication adherence.Conclusion: Medication adherence in children with CPP is relatively better, and the factors leading to poor medication adherence are mainly on the caregivers of pediatric patients. It is recommended to increase the health education among caregivers of children with CPP to enhance the cognition of the condition and medication, and further improve the therapeutic efficacy for CPP. |
| first_indexed | 2024-03-08T16:08:11Z |
| format | Article |
| id | doaj.art-3736cd9404ee4f419f3905870e957959 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T16:08:11Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-3736cd9404ee4f419f3905870e9579592024-01-08T04:27:00ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-01-011410.3389/fphar.2023.12691581269158Prevalence and factors associated with medication adherence in children with central precocious puberty: a cross-sectional studyChunsong Yang0Chunsong Yang1Chunsong Yang2Chunsong Yang3Xia Song4Xia Song5Xia Song6Xia Song7Xia Song8Jin Wu9Lingli Zhang10Lingli Zhang11Lingli Zhang12Lingli Zhang13Lingli Zhang14Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaNMPA Key Laboratory for Technical Research on Drug Products in Vitro and in Vivo Correlation, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaDepartment of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaNMPA Key Laboratory for Technical Research on Drug Products in Vitro and in Vivo Correlation, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaWest China School of Pharmacy, Sichuan University, Chengdu, ChinaDepartment of Children’s Genetic Endocrinology and Metabolism, West China Second University Hospital, Sichuan University, Chengdu, ChinaDepartment of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaNMPA Key Laboratory for Technical Research on Drug Products in Vitro and in Vivo Correlation, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaChinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, ChinaObjectives: This study aimed to investigate the prevalence and influencing factors of medication adherence in children with central precocious puberty (CPP), and provide references for clinical practice.Methods: Children under 12 years of age with CPP and their caregivers at a women’s and children’s hospital were selected for a cross-sectional study from February to May 2023, and a questionnaire was used to collect basic characteristics of pediatric patients and their caregivers, information of medication, cognition of medication, and medication adherence. The 8-item Morisky Medication Adherence Scale (MMAS-8) was adopted to assess medication adherence, and the potential influencing factors were explored by univariate and multivariate analyses.Results: A total of 125 valid questionnaires were collected. The medication adherence rate of children with CPP reported by caregivers was 76.0%. The univariate analysis showed that the percentage of parental caregivers (p = 0.027), the age of caregivers (p = 0.029), the education level of caregivers (p = 0.001), the financial burden (p < 0.000), the incidence of adverse effects (p = 0.008), and the cognition of medication including the importance of medication (p = 0.002), the dosage of medication (p = 0.002), the adverse effects of medication (p = 0.007), the harm of non-compliance with medication (p < 0.000), and the evaluation of the price of medication (p = 0.003) in the poor adherence group were significantly inferior to those in the better adherence group. The multivariate analysis showed that the higher incidence of adverse effects (p = 0.20), not understanding the harm of non-compliance with medication (p = 0.004), and evaluation of the price of medication as expensive (p = 0.043) were independent risk factors for poor medication adherence.Conclusion: Medication adherence in children with CPP is relatively better, and the factors leading to poor medication adherence are mainly on the caregivers of pediatric patients. It is recommended to increase the health education among caregivers of children with CPP to enhance the cognition of the condition and medication, and further improve the therapeutic efficacy for CPP.https://www.frontiersin.org/articles/10.3389/fphar.2023.1269158/fullcentral precocious pubertymedication adherenceinfluencing factorscrosssectional surveychildren |
| spellingShingle | Chunsong Yang Chunsong Yang Chunsong Yang Chunsong Yang Xia Song Xia Song Xia Song Xia Song Xia Song Jin Wu Lingli Zhang Lingli Zhang Lingli Zhang Lingli Zhang Lingli Zhang Prevalence and factors associated with medication adherence in children with central precocious puberty: a cross-sectional study Frontiers in Pharmacology central precocious puberty medication adherence influencing factors crosssectional survey children |
| title | Prevalence and factors associated with medication adherence in children with central precocious puberty: a cross-sectional study |
| title_full | Prevalence and factors associated with medication adherence in children with central precocious puberty: a cross-sectional study |
| title_fullStr | Prevalence and factors associated with medication adherence in children with central precocious puberty: a cross-sectional study |
| title_full_unstemmed | Prevalence and factors associated with medication adherence in children with central precocious puberty: a cross-sectional study |
| title_short | Prevalence and factors associated with medication adherence in children with central precocious puberty: a cross-sectional study |
| title_sort | prevalence and factors associated with medication adherence in children with central precocious puberty a cross sectional study |
| topic | central precocious puberty medication adherence influencing factors crosssectional survey children |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1269158/full |
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