Co-registration of optoacoustic tomography and magnetic resonance imaging data from murine tumour models
As optoacoustic tomography (OT) emerges as a mainstream pre-clinical imaging modality, understanding the relationship between optoacoustic and other imaging biomarkers in the context of the underlying tissue biology becomes vitally important. Complementary insight into tumour vasculature and hypoxia...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | Photoacoustics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597919300709 |
| _version_ | 1818243336418361344 |
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| author | Marcel Gehrung Michal Tomaszewski Dominick McIntyre Jonathan Disselhorst Sarah Bohndiek |
| author_facet | Marcel Gehrung Michal Tomaszewski Dominick McIntyre Jonathan Disselhorst Sarah Bohndiek |
| author_sort | Marcel Gehrung |
| collection | DOAJ |
| description | As optoacoustic tomography (OT) emerges as a mainstream pre-clinical imaging modality, understanding the relationship between optoacoustic and other imaging biomarkers in the context of the underlying tissue biology becomes vitally important. Complementary insight into tumour vasculature and hypoxia can be gained using OT alongside magnetic resonance imaging (MRI)-based techniques. To evaluate the relationship between these metrics and the relative performance of the two modalities in assessment of tumour physiology, co-registration of their output imaging data is required. Unfortunately, this poses a significant challenge due to differences in animal positioning during imaging. Here, we present an integrated framework for registration of OT and MR image data in mice. Our framework combines a novel MR animal holder, to improve animal positioning during imaging, and a landmark-based software co-registration algorithm. We demonstrate that our protocol significantly improves registration of both body and tumour contours between these modalities, enabling more precise multi-modal tumour characterisation. |
| first_indexed | 2024-12-12T13:59:30Z |
| format | Article |
| id | doaj.art-3737c81aed93418989912cc8b723b86e |
| institution | Directory Open Access Journal |
| issn | 2213-5979 |
| language | English |
| last_indexed | 2024-12-12T13:59:30Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj.art-3737c81aed93418989912cc8b723b86e2022-12-22T00:22:23ZengElsevierPhotoacoustics2213-59792020-06-0118100147Co-registration of optoacoustic tomography and magnetic resonance imaging data from murine tumour modelsMarcel Gehrung0Michal Tomaszewski1Dominick McIntyre2Jonathan Disselhorst3Sarah Bohndiek4Department of Physics, University of Cambridge, UK; Cancer Research UK Cambridge Institute, University of Cambridge, UK; Werner Siemens Imaging Center, Preclinical Imaging and Radiopharmacy, University of Tuebingen, GermanyDepartment of Physics, University of Cambridge, UK; Cancer Research UK Cambridge Institute, University of Cambridge, UKCancer Research UK Cambridge Institute, University of Cambridge, UKWerner Siemens Imaging Center, Preclinical Imaging and Radiopharmacy, University of Tuebingen, GermanyDepartment of Physics, University of Cambridge, UK; Cancer Research UK Cambridge Institute, University of Cambridge, UK; Corresponding author at: S E Bohndiek, Department of Physics and Cancer Research UK Cambridge Institute, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, UK.As optoacoustic tomography (OT) emerges as a mainstream pre-clinical imaging modality, understanding the relationship between optoacoustic and other imaging biomarkers in the context of the underlying tissue biology becomes vitally important. Complementary insight into tumour vasculature and hypoxia can be gained using OT alongside magnetic resonance imaging (MRI)-based techniques. To evaluate the relationship between these metrics and the relative performance of the two modalities in assessment of tumour physiology, co-registration of their output imaging data is required. Unfortunately, this poses a significant challenge due to differences in animal positioning during imaging. Here, we present an integrated framework for registration of OT and MR image data in mice. Our framework combines a novel MR animal holder, to improve animal positioning during imaging, and a landmark-based software co-registration algorithm. We demonstrate that our protocol significantly improves registration of both body and tumour contours between these modalities, enabling more precise multi-modal tumour characterisation.http://www.sciencedirect.com/science/article/pii/S2213597919300709Optoacoustic tomographyMagnetic resonance imagingImage registration |
| spellingShingle | Marcel Gehrung Michal Tomaszewski Dominick McIntyre Jonathan Disselhorst Sarah Bohndiek Co-registration of optoacoustic tomography and magnetic resonance imaging data from murine tumour models Photoacoustics Optoacoustic tomography Magnetic resonance imaging Image registration |
| title | Co-registration of optoacoustic tomography and magnetic resonance imaging data from murine tumour models |
| title_full | Co-registration of optoacoustic tomography and magnetic resonance imaging data from murine tumour models |
| title_fullStr | Co-registration of optoacoustic tomography and magnetic resonance imaging data from murine tumour models |
| title_full_unstemmed | Co-registration of optoacoustic tomography and magnetic resonance imaging data from murine tumour models |
| title_short | Co-registration of optoacoustic tomography and magnetic resonance imaging data from murine tumour models |
| title_sort | co registration of optoacoustic tomography and magnetic resonance imaging data from murine tumour models |
| topic | Optoacoustic tomography Magnetic resonance imaging Image registration |
| url | http://www.sciencedirect.com/science/article/pii/S2213597919300709 |
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