Fabrication of Bacterial Cellulose-Curcumin Nanocomposite as a Novel Dressing for Partial Thickness Skin Burn
The current study aimed to fabricate curcumin-loaded bacterial cellulose (BC-Cur) nanocomposite as a potential wound dressing for partial thickness burns by utilizing the therapeutic features of curcumin and unique structural, physico-chemical, and biological features of bacterial cellulose (BC). Ch...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fbioe.2020.553037/full |
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| author | Wasim Sajjad Feng He Muhammad Wajid Ullah Muhammad Ikram Shahid Masood Shah Romana Khan Taous Khan Ayesha Khalid Guang Yang Fazli Wahid |
| author_facet | Wasim Sajjad Feng He Muhammad Wajid Ullah Muhammad Ikram Shahid Masood Shah Romana Khan Taous Khan Ayesha Khalid Guang Yang Fazli Wahid |
| author_sort | Wasim Sajjad |
| collection | DOAJ |
| description | The current study aimed to fabricate curcumin-loaded bacterial cellulose (BC-Cur) nanocomposite as a potential wound dressing for partial thickness burns by utilizing the therapeutic features of curcumin and unique structural, physico-chemical, and biological features of bacterial cellulose (BC). Characterization analyses confirmed the successful impregnation of curcumin into the BC matrix. Biocompatibility studies showed the better attachment and proliferation of fibroblast cells on the BC-Cur nanocomposite. The antibacterial potential of curcumin was tested against Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Salmonella typhimurium (S. typhimurium), and Staphylococcus aureus (S. aureus). Wound healing analysis of partial-thickness burns in Balbc mice showed an accelerated wound closure up to 64.25% after 15 days in the BC-Cur nanocomposite treated group. Histological studies showed healthy granulation tissues, fine re-epithelialization, vascularization, and resurfacing of wound bed in the BC-Cur nanocomposite group. These results indicate that combining BC with curcumin significantly improved the healing pattern. Thus, it can be concluded that the fabricated biomaterial could provide a base for the development of promising alternatives for the conventional dressing system in treating burns. |
| first_indexed | 2024-04-13T18:11:02Z |
| format | Article |
| id | doaj.art-3738a8b625cf4cbb9e32d83e85e0dcd7 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-13T18:11:02Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-3738a8b625cf4cbb9e32d83e85e0dcd72022-12-22T02:35:53ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-09-01810.3389/fbioe.2020.553037553037Fabrication of Bacterial Cellulose-Curcumin Nanocomposite as a Novel Dressing for Partial Thickness Skin BurnWasim Sajjad0Feng He1Muhammad Wajid Ullah2Muhammad Ikram3Shahid Masood Shah4Romana Khan5Taous Khan6Ayesha Khalid7Guang Yang8Fazli Wahid9Department of Biomedical Sciences, Pak-Austria Fachhochschule Institute of Applied Sciences and Technology, Haripur, PakistanHubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang, ChinaDepartment of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pharmacy, COMSATS University Islamabad, Abbottabad, PakistanDepartment of Biotechnology, COMSATS University Islamabad, Abbottabad, PakistanDepartment of Environmental Sciences, COMSATS University Islamabad, Abbottabad, PakistanDepartment of Pharmacy, COMSATS University Islamabad, Abbottabad, PakistanDepartment of Biotechnology, COMSATS University Islamabad, Abbottabad, PakistanDepartment of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Biomedical Sciences, Pak-Austria Fachhochschule Institute of Applied Sciences and Technology, Haripur, PakistanThe current study aimed to fabricate curcumin-loaded bacterial cellulose (BC-Cur) nanocomposite as a potential wound dressing for partial thickness burns by utilizing the therapeutic features of curcumin and unique structural, physico-chemical, and biological features of bacterial cellulose (BC). Characterization analyses confirmed the successful impregnation of curcumin into the BC matrix. Biocompatibility studies showed the better attachment and proliferation of fibroblast cells on the BC-Cur nanocomposite. The antibacterial potential of curcumin was tested against Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Salmonella typhimurium (S. typhimurium), and Staphylococcus aureus (S. aureus). Wound healing analysis of partial-thickness burns in Balbc mice showed an accelerated wound closure up to 64.25% after 15 days in the BC-Cur nanocomposite treated group. Histological studies showed healthy granulation tissues, fine re-epithelialization, vascularization, and resurfacing of wound bed in the BC-Cur nanocomposite group. These results indicate that combining BC with curcumin significantly improved the healing pattern. Thus, it can be concluded that the fabricated biomaterial could provide a base for the development of promising alternatives for the conventional dressing system in treating burns.https://www.frontiersin.org/article/10.3389/fbioe.2020.553037/fullbacterial cellulosebiocompatibilityburnscurcumintissue regenerationwound healing |
| spellingShingle | Wasim Sajjad Feng He Muhammad Wajid Ullah Muhammad Ikram Shahid Masood Shah Romana Khan Taous Khan Ayesha Khalid Guang Yang Fazli Wahid Fabrication of Bacterial Cellulose-Curcumin Nanocomposite as a Novel Dressing for Partial Thickness Skin Burn Frontiers in Bioengineering and Biotechnology bacterial cellulose biocompatibility burns curcumin tissue regeneration wound healing |
| title | Fabrication of Bacterial Cellulose-Curcumin Nanocomposite as a Novel Dressing for Partial Thickness Skin Burn |
| title_full | Fabrication of Bacterial Cellulose-Curcumin Nanocomposite as a Novel Dressing for Partial Thickness Skin Burn |
| title_fullStr | Fabrication of Bacterial Cellulose-Curcumin Nanocomposite as a Novel Dressing for Partial Thickness Skin Burn |
| title_full_unstemmed | Fabrication of Bacterial Cellulose-Curcumin Nanocomposite as a Novel Dressing for Partial Thickness Skin Burn |
| title_short | Fabrication of Bacterial Cellulose-Curcumin Nanocomposite as a Novel Dressing for Partial Thickness Skin Burn |
| title_sort | fabrication of bacterial cellulose curcumin nanocomposite as a novel dressing for partial thickness skin burn |
| topic | bacterial cellulose biocompatibility burns curcumin tissue regeneration wound healing |
| url | https://www.frontiersin.org/article/10.3389/fbioe.2020.553037/full |
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