A soft, high-density neuroelectronic array
Abstract Techniques to study brain activities have evolved dramatically, yet tremendous challenges remain in acquiring high-throughput electrophysiological recordings minimally invasively. Here, we develop an integrated neuroelectronic array that is filamentary, high-density and flexible. Specifical...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-08-01
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| Series: | npj Flexible Electronics |
| Online Access: | https://doi.org/10.1038/s41528-023-00271-2 |
| _version_ | 1797555728298278912 |
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| author | Kyung Jin Seo Mackenna Hill Jaehyeon Ryu Chia-Han Chiang Iakov Rachinskiy Yi Qiang Dongyeol Jang Michael Trumpis Charles Wang Jonathan Viventi Hui Fang |
| author_facet | Kyung Jin Seo Mackenna Hill Jaehyeon Ryu Chia-Han Chiang Iakov Rachinskiy Yi Qiang Dongyeol Jang Michael Trumpis Charles Wang Jonathan Viventi Hui Fang |
| author_sort | Kyung Jin Seo |
| collection | DOAJ |
| description | Abstract Techniques to study brain activities have evolved dramatically, yet tremendous challenges remain in acquiring high-throughput electrophysiological recordings minimally invasively. Here, we develop an integrated neuroelectronic array that is filamentary, high-density and flexible. Specifically, with a design of single-transistor multiplexing and current sensing, the total 256 neuroelectrodes achieve only a 2.3 × 0.3 mm2 area, unprecedentedly on a flexible substrate. A single-transistor multiplexing acquisition circuit further reduces noise from the electrodes, decreases the footprint of each pixel, and potentially increases the device’s lifetime. The filamentary neuroelectronic array also integrates with a rollable contact pad design, allowing the device to be injected through a syringe, enabling potential minimally invasive array delivery. Successful acute auditory experiments in rats validate the ability of the array to record neural signals with high tone decoding accuracy. Together, these results establish soft, high-density neuroelectronic arrays as promising devices for neuroscience research and clinical applications. |
| first_indexed | 2024-03-10T16:51:35Z |
| format | Article |
| id | doaj.art-3738d3a11fcb477981dcdbe58a352212 |
| institution | Directory Open Access Journal |
| issn | 2397-4621 |
| language | English |
| last_indexed | 2024-03-10T16:51:35Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Flexible Electronics |
| spelling | doaj.art-3738d3a11fcb477981dcdbe58a3522122023-11-20T11:16:24ZengNature Portfolionpj Flexible Electronics2397-46212023-08-01711810.1038/s41528-023-00271-2A soft, high-density neuroelectronic arrayKyung Jin Seo0Mackenna Hill1Jaehyeon Ryu2Chia-Han Chiang3Iakov Rachinskiy4Yi Qiang5Dongyeol Jang6Michael Trumpis7Charles Wang8Jonathan Viventi9Hui Fang10Thayer School of Engineering, Dartmouth CollegeDepartment of Biomedical Engineering, Duke UniversityThayer School of Engineering, Dartmouth CollegeDepartment of Biomedical Engineering, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityThayer School of Engineering, Dartmouth CollegeThayer School of Engineering, Dartmouth CollegeDepartment of Biomedical Engineering, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityThayer School of Engineering, Dartmouth CollegeAbstract Techniques to study brain activities have evolved dramatically, yet tremendous challenges remain in acquiring high-throughput electrophysiological recordings minimally invasively. Here, we develop an integrated neuroelectronic array that is filamentary, high-density and flexible. Specifically, with a design of single-transistor multiplexing and current sensing, the total 256 neuroelectrodes achieve only a 2.3 × 0.3 mm2 area, unprecedentedly on a flexible substrate. A single-transistor multiplexing acquisition circuit further reduces noise from the electrodes, decreases the footprint of each pixel, and potentially increases the device’s lifetime. The filamentary neuroelectronic array also integrates with a rollable contact pad design, allowing the device to be injected through a syringe, enabling potential minimally invasive array delivery. Successful acute auditory experiments in rats validate the ability of the array to record neural signals with high tone decoding accuracy. Together, these results establish soft, high-density neuroelectronic arrays as promising devices for neuroscience research and clinical applications.https://doi.org/10.1038/s41528-023-00271-2 |
| spellingShingle | Kyung Jin Seo Mackenna Hill Jaehyeon Ryu Chia-Han Chiang Iakov Rachinskiy Yi Qiang Dongyeol Jang Michael Trumpis Charles Wang Jonathan Viventi Hui Fang A soft, high-density neuroelectronic array npj Flexible Electronics |
| title | A soft, high-density neuroelectronic array |
| title_full | A soft, high-density neuroelectronic array |
| title_fullStr | A soft, high-density neuroelectronic array |
| title_full_unstemmed | A soft, high-density neuroelectronic array |
| title_short | A soft, high-density neuroelectronic array |
| title_sort | soft high density neuroelectronic array |
| url | https://doi.org/10.1038/s41528-023-00271-2 |
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