Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery
In the generational evolution of nano-based drug delivery carriers, active targeting has been a major milestone for improved and selective drug accumulation in tissues and cell types beyond the existing passive targeting capabilities. Among the various active targeting moieties, chlorotoxin, a pepti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/12/2613 |
| _version_ | 1797455708399075328 |
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| author | Archana Shrestha Behnaz Lahooti Constantinos M. Mikelis George Mattheolabakis |
| author_facet | Archana Shrestha Behnaz Lahooti Constantinos M. Mikelis George Mattheolabakis |
| author_sort | Archana Shrestha |
| collection | DOAJ |
| description | In the generational evolution of nano-based drug delivery carriers, active targeting has been a major milestone for improved and selective drug accumulation in tissues and cell types beyond the existing passive targeting capabilities. Among the various active targeting moieties, chlorotoxin, a peptide extracted from scorpions, demonstrated promising tumor cell accumulation and selection. With lung cancer being among the leading diagnoses of cancer-related deaths in both men and women, novel therapeutic methodologies utilizing nanotechnology for drug delivery emerged. Given chlorotoxin’s promising biological activity, we explore its potential against lung cancer and its utilization for active targeting against this cancer’s tumor cells. Our analysis indicates that despite the extensive chlorotoxin’s research against glioblastoma, lung cancer research with the molecule has been limited, despite some promising early results. |
| first_indexed | 2024-03-09T15:58:11Z |
| format | Article |
| id | doaj.art-373a5b114ee440b19fadd825070f974f |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T15:58:11Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-373a5b114ee440b19fadd825070f974f2023-11-24T17:18:57ZengMDPI AGPharmaceutics1999-49232022-11-011412261310.3390/pharmaceutics14122613Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug DeliveryArchana Shrestha0Behnaz Lahooti1Constantinos M. Mikelis2George Mattheolabakis3School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USADepartment of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USADepartment of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USASchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USAIn the generational evolution of nano-based drug delivery carriers, active targeting has been a major milestone for improved and selective drug accumulation in tissues and cell types beyond the existing passive targeting capabilities. Among the various active targeting moieties, chlorotoxin, a peptide extracted from scorpions, demonstrated promising tumor cell accumulation and selection. With lung cancer being among the leading diagnoses of cancer-related deaths in both men and women, novel therapeutic methodologies utilizing nanotechnology for drug delivery emerged. Given chlorotoxin’s promising biological activity, we explore its potential against lung cancer and its utilization for active targeting against this cancer’s tumor cells. Our analysis indicates that despite the extensive chlorotoxin’s research against glioblastoma, lung cancer research with the molecule has been limited, despite some promising early results.https://www.mdpi.com/1999-4923/14/12/2613nanoparticleschlorotoxinlung canceractive targetingcytotoxicitymorphometric analysis |
| spellingShingle | Archana Shrestha Behnaz Lahooti Constantinos M. Mikelis George Mattheolabakis Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery Pharmaceutics nanoparticles chlorotoxin lung cancer active targeting cytotoxicity morphometric analysis |
| title | Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery |
| title_full | Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery |
| title_fullStr | Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery |
| title_full_unstemmed | Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery |
| title_short | Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery |
| title_sort | chlorotoxin and lung cancer a targeting perspective for drug delivery |
| topic | nanoparticles chlorotoxin lung cancer active targeting cytotoxicity morphometric analysis |
| url | https://www.mdpi.com/1999-4923/14/12/2613 |
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