Impact of endolysosomal dysfunction upon exosomes in neurodegenerative diseases
Although the factors contributing to the pathogenesis of neurodegenerative diseases remain elusive, endolysosomal pathway is emerging as a key player in the pathogenesis of neurodegenerative diseases. The link between endolysosomal dysfunction and neurodegeneration is supported by genetic studies id...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996122000420 |
| _version_ | 1818938545650270208 |
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| author | Maria Izco Estefania Carlos Lydia Alvarez-Erviti |
| author_facet | Maria Izco Estefania Carlos Lydia Alvarez-Erviti |
| author_sort | Maria Izco |
| collection | DOAJ |
| description | Although the factors contributing to the pathogenesis of neurodegenerative diseases remain elusive, endolysosomal pathway is emerging as a key player in the pathogenesis of neurodegenerative diseases. The link between endolysosomal dysfunction and neurodegeneration is supported by genetic studies identifying disease mutations in genes controlling endolysosomal function. Growing evidence suggests that endolysosomal dysfunction affect the production, secretion and content of exosomes. Current data suggests that exosomes play a key role in Parkinson's disease (PD) and Alzheimer's disease (AD) progression, interfering with the transmission of pathological proteins or neuroinflammatory factors related to neurodegenerative diseases. This review summarizes recent advances in the role of endolysosomal dysfunction in the spreading of pathological proteins mediated by exosomes in the two most common neurodegenerative diseases, AD and PD. |
| first_indexed | 2024-12-20T06:09:34Z |
| format | Article |
| id | doaj.art-373cd47d289840bbb7387d765229031e |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-20T06:09:34Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-373cd47d289840bbb7387d765229031e2022-12-21T19:50:43ZengElsevierNeurobiology of Disease1095-953X2022-05-01166105651Impact of endolysosomal dysfunction upon exosomes in neurodegenerative diseasesMaria Izco0Estefania Carlos1Lydia Alvarez-Erviti2Laboratory of Molecular Neurobiology, Center for Biomedical Research of La Rioja (CIBIR), Piqueras 98, 3th floor, 26006 Logroño, SpainLaboratory of Molecular Neurobiology, Center for Biomedical Research of La Rioja (CIBIR), Piqueras 98, 3th floor, 26006 Logroño, SpainCorresponding author.; Laboratory of Molecular Neurobiology, Center for Biomedical Research of La Rioja (CIBIR), Piqueras 98, 3th floor, 26006 Logroño, SpainAlthough the factors contributing to the pathogenesis of neurodegenerative diseases remain elusive, endolysosomal pathway is emerging as a key player in the pathogenesis of neurodegenerative diseases. The link between endolysosomal dysfunction and neurodegeneration is supported by genetic studies identifying disease mutations in genes controlling endolysosomal function. Growing evidence suggests that endolysosomal dysfunction affect the production, secretion and content of exosomes. Current data suggests that exosomes play a key role in Parkinson's disease (PD) and Alzheimer's disease (AD) progression, interfering with the transmission of pathological proteins or neuroinflammatory factors related to neurodegenerative diseases. This review summarizes recent advances in the role of endolysosomal dysfunction in the spreading of pathological proteins mediated by exosomes in the two most common neurodegenerative diseases, AD and PD.http://www.sciencedirect.com/science/article/pii/S0969996122000420Alzheimer's diseaseParkinson's diseaseEndolysosomal dysfunctionExosomesPathology progression |
| spellingShingle | Maria Izco Estefania Carlos Lydia Alvarez-Erviti Impact of endolysosomal dysfunction upon exosomes in neurodegenerative diseases Neurobiology of Disease Alzheimer's disease Parkinson's disease Endolysosomal dysfunction Exosomes Pathology progression |
| title | Impact of endolysosomal dysfunction upon exosomes in neurodegenerative diseases |
| title_full | Impact of endolysosomal dysfunction upon exosomes in neurodegenerative diseases |
| title_fullStr | Impact of endolysosomal dysfunction upon exosomes in neurodegenerative diseases |
| title_full_unstemmed | Impact of endolysosomal dysfunction upon exosomes in neurodegenerative diseases |
| title_short | Impact of endolysosomal dysfunction upon exosomes in neurodegenerative diseases |
| title_sort | impact of endolysosomal dysfunction upon exosomes in neurodegenerative diseases |
| topic | Alzheimer's disease Parkinson's disease Endolysosomal dysfunction Exosomes Pathology progression |
| url | http://www.sciencedirect.com/science/article/pii/S0969996122000420 |
| work_keys_str_mv | AT mariaizco impactofendolysosomaldysfunctionuponexosomesinneurodegenerativediseases AT estefaniacarlos impactofendolysosomaldysfunctionuponexosomesinneurodegenerativediseases AT lydiaalvarezerviti impactofendolysosomaldysfunctionuponexosomesinneurodegenerativediseases |